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    TRIM55 tripartite motif containing 55 [ Homo sapiens (human) ]

    Gene ID: 84675, updated on 5-Mar-2024

    Summary

    Official Symbol
    TRIM55provided by HGNC
    Official Full Name
    tripartite motif containing 55provided by HGNC
    Primary source
    HGNC:HGNC:14215
    See related
    Ensembl:ENSG00000147573 MIM:606469; AllianceGenome:HGNC:14215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF29; muRF2; MURF-2
    Summary
    The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 14.3), liver (RPKM 6.5) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM55 in Genome Data Viewer
    Location:
    8q13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66113351..66175485)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66538238..66601172)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67039364..67087720)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27469 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:66862529-66863728 Neighboring gene uncharacterized LOC105375883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27470 Neighboring gene Sharpr-MPRA regulatory region 3041 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19250 Neighboring gene Sharpr-MPRA regulatory region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27472 Neighboring gene H3K27ac hESC enhancers GRCh37_chr8:67025273-67025924 and GRCh37_chr8:67025925-67026577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27471 Neighboring gene tRNA-Tyr (anticodon GTA) 5-1 Neighboring gene tRNA-Tyr (anticodon GTA) 5-2 Neighboring gene tRNA-Ala (anticodon AGC) 8-2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:67035753-67036952 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67038910-67039182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27476 Neighboring gene uncharacterized LOC112268029 Neighboring gene uncharacterized LOC124901954 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:67098699-67099309 Neighboring gene corticotropin releasing hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
    Knockdown of tripartite motif containing 55 (TRIM55) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • AC084082.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in diapedesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tripartite motif-containing protein 55
    Names
    muscle specific ring finger 2
    muscle-specific RING finger protein 2
    ring finger protein 29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033058.3NP_149047.2  tripartite motif-containing protein 55 isoform 2

      See identical proteins and their annotated locations for NP_149047.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon within the coding region compared to variant 1, which causes a frameshift. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AJ431704, AK091310
      Consensus CDS
      CCDS6187.1
      UniProtKB/Swiss-Prot
      Q9BYV6
      Related
      ENSP00000276573.7, ENST00000276573.11
      Conserved Domains (3) summary
      cd00162
      Location:2685
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:119161
      zf-B_box; B-box zinc finger
      cl23765
      Location:168294
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_184085.2NP_908973.1  tripartite motif-containing protein 55 isoform 1

      See identical proteins and their annotated locations for NP_908973.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ291712, AK091310
      Consensus CDS
      CCDS6184.1
      UniProtKB/Swiss-Prot
      B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
      Related
      ENSP00000323913.4, ENST00000315962.9
      Conserved Domains (3) summary
      cd00162
      Location:2685
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:119161
      zf-B_box; B-box zinc finger
      cl23765
      Location:168294
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. NM_184086.2NP_908974.1  tripartite motif-containing protein 55 isoform 3

      See identical proteins and their annotated locations for NP_908974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon within the coding region compared to variant 1. The resulting isoform (3) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AK091310
      Consensus CDS
      CCDS6185.1
      UniProtKB/Swiss-Prot
      Q9BYV6
      Related
      ENSP00000297348.8, ENST00000353317.9
      Conserved Domains (3) summary
      pfam00643
      Location:119161
      zf-B_box; B-box zinc finger
      cd16760
      Location:2184
      RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
      cl25407
      Location:168294
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    4. NM_184087.2NP_908975.1  tripartite motif-containing protein 55 isoform 4

      See identical proteins and their annotated locations for NP_908975.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four exons within the coding region compared to variant 1. The translation frame remains the same. The resulting isoform (4) lacks an internal region, as compared to isoform 1. This isoform (4) was detected specifically in cardiac muscle.
      Source sequence(s)
      AJ277493, AK091310
      Consensus CDS
      CCDS6186.1
      UniProtKB/Swiss-Prot
      Q9BYV6
      Related
      ENSP00000332302.4, ENST00000350034.4
      Conserved Domains (2) summary
      cd16760
      Location:2184
      RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
      cl00034
      Location:122166
      Bbox_SF; B-box-type zinc finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      66113351..66175485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517617.3XP_011515919.1  tripartite motif-containing protein 55 isoform X4

      Conserved Domains (2) summary
      pfam00643
      Location:139
      zf-B_box; B-box zinc finger
      cl23765
      Location:46172
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. XM_017013908.2XP_016869397.1  tripartite motif-containing protein 55 isoform X2

    3. XM_005251316.5XP_005251373.1  tripartite motif-containing protein 55 isoform X1

      Conserved Domains (3) summary
      cd00162
      Location:2685
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:119161
      zf-B_box; B-box zinc finger
      cl23765
      Location:168294
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    4. XM_024447308.1XP_024303076.1  tripartite motif-containing protein 55 isoform X3

      Conserved Domains (3) summary
      pfam00643
      Location:119161
      zf-B_box; B-box zinc finger
      cd16760
      Location:2184
      RING-HC_MuRF2; RING finger, HC subclass, found in muscle-specific RING finger protein 2 (MuRF-2) and similar proteins
      cl25407
      Location:168294
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      66538238..66601172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361361.1XP_054217336.1  tripartite motif-containing protein 55 isoform X5

      UniProtKB/Swiss-Prot
      B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
    2. XM_054361363.1XP_054217338.1  tripartite motif-containing protein 55 isoform X5

      UniProtKB/Swiss-Prot
      B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
    3. XM_054361369.1XP_054217344.1  tripartite motif-containing protein 55 isoform X4

    4. XM_054361365.1XP_054217340.1  tripartite motif-containing protein 55 isoform X6

    5. XM_054361364.1XP_054217339.1  tripartite motif-containing protein 55 isoform X1

    6. XM_054361360.1XP_054217335.1  tripartite motif-containing protein 55 isoform X5

      UniProtKB/Swiss-Prot
      B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
    7. XM_054361362.1XP_054217337.1  tripartite motif-containing protein 55 isoform X5

      UniProtKB/Swiss-Prot
      B3KRC0, B3KRJ3, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5, Q9BYV6
    8. XM_054361368.1XP_054217343.1  tripartite motif-containing protein 55 isoform X3

    9. XM_054361367.1XP_054217342.1  tripartite motif-containing protein 55 isoform X7

    10. XM_054361366.1XP_054217341.1  tripartite motif-containing protein 55 isoform X2