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    SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 6714, updated on 20-Feb-2024

    Summary

    Official Symbol
    SRCprovided by HGNC
    Official Full Name
    SRC proto-oncogene, non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:11283
    See related
    Ensembl:ENSG00000197122 MIM:190090; AllianceGenome:HGNC:11283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASV; SRC1; THC6; c-SRC; p60-Src
    Summary
    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 19.0), testis (RPKM 19.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRC in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (37344699..37406050)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39068774..39130114)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35973102..36034453)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:35918028-35918932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17834 Neighboring gene mannosidase beta like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35943167-35944074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35944075-35944984 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35947577-35948274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35964723-35965222 Neighboring gene uncharacterized LOC105372606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35968539-35969071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35975052-35975552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35987177-35987747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36019051-36019552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36022575-36023431 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36023432-36024287 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36024288-36025144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36025145-36026001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36026002-36026858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36035731-36036650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36040408-36040917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36040918-36041426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36049663-36050276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36054060-36054560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36054561-36055061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36070038-36070538 Neighboring gene ribosomal protein L7a pseudogene 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36114871-36115516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36115517-36116161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36146997-36147860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36147861-36148724 Neighboring gene BLCAP apoptosis inducing factor Neighboring gene neuronatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Thrombocytopenia 6
    MedGen: C4310789 OMIM: 616937 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of retinopathy in individuals without diabetes.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 activates SRC in monocyte derived dendritic cells PubMed
    Knockdown of c-SRC tyrosine kinase by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    env Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
    Nef nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
    nef High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions PubMed
    nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
    nef The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef PubMed
    Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
    tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed
    tat HIV-1 Tat and cocaine treatment upregulates the expreesion of phophorylated SRC protein in human pulmonary arterial smooth muscle cells PubMed
    tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed
    tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
    tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
    tat HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner PubMed
    tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
    reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables BMP receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables connexin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERBB2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    involved_in T cell costimulation TAS
    Traceable Author Statement
    more info
     
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptide hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to progesterone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to prolactin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in entry of bacterium into host cell TAS
    Traceable Author Statement
    more info
     
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intestinal epithelial cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration TAS
    Traceable Author Statement
    more info
     
    involved_in macroautophagy TAS
    Traceable Author Statement
    more info
     
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to antigenic stimulus TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoclast development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of integrin activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of male germ cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of non-membrane spanning protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in primary ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in progesterone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in progesterone receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of caveolin-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell projection assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of toll-like receptor 3 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mineralocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic specialization, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase Src
    Names
    proto-oncogene c-Src
    protooncogene SRC, Rous sarcoma
    tyrosine kinase pp60c-src
    tyrosine-protein kinase SRC-1
    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
    NP_005408.1
    NP_938033.1
    XP_016883515.1
    XP_047296352.1
    XP_047296353.1
    XP_047296354.1
    XP_047296355.1
    XP_047296356.1
    XP_047296357.1
    XP_047296358.1
    XP_047296359.1
    XP_047296360.1
    XP_047296361.1
    XP_047296362.1
    XP_047296363.1
    XP_047296364.1
    XP_047296365.1
    XP_047296366.1
    XP_047296367.1
    XP_047296368.1
    XP_047296369.1
    XP_054179874.1
    XP_054179875.1
    XP_054179876.1
    XP_054179877.1
    XP_054179878.1
    XP_054179879.1
    XP_054179880.1
    XP_054179881.1
    XP_054179882.1
    XP_054179883.1
    XP_054179884.1
    XP_054179885.1
    XP_054179886.1
    XP_054179887.1
    XP_054179888.1
    XP_054179889.1
    XP_054179890.1
    XP_054179891.1
    XP_054179892.1
    XP_054189256.1
    XP_054189257.1
    XP_054189258.1
    XP_054189259.1
    XP_054189260.1
    XP_054189261.1
    XP_054189262.1
    XP_054189263.1
    XP_054189264.1
    XP_054189265.1
    XP_054189266.1
    XP_054189267.1
    XP_054189268.1
    XP_054189269.1
    XP_054189270.1
    XP_054189271.1
    XP_054189272.1
    XP_054189273.1
    XP_054189274.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023033.1 RefSeqGene

      Range
      6444..65748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1018

    mRNA and Protein(s)

    1. NM_005417.5NP_005408.1  proto-oncogene tyrosine-protein kinase Src

      See identical proteins and their annotated locations for NP_005408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL034422, AL133293, KF456893
      Consensus CDS
      CCDS13294.1
      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Conserved Domains (3) summary
      cd10365
      Location:147247
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88143
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:260536
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    2. NM_198291.3NP_938033.1  proto-oncogene tyrosine-protein kinase Src

      See identical proteins and their annotated locations for NP_938033.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL133293, AW135290, BC051270, CD364525, HY016645
      Consensus CDS
      CCDS13294.1
      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Related
      ENSP00000362680.2, ENST00000373578.7
      Conserved Domains (3) summary
      cd10365
      Location:147247
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88143
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:260536
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      37344699..37406050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440399.1XP_047296355.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_047440400.1XP_047296356.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_047440407.1XP_047296363.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_047440396.1XP_047296352.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_047440402.1XP_047296358.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_047440411.1XP_047296367.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_047440405.1XP_047296361.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_047440408.1XP_047296364.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_047440397.1XP_047296353.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_047440401.1XP_047296357.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_047440410.1XP_047296366.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_047440406.1XP_047296362.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_047440398.1XP_047296354.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_047440403.1XP_047296359.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_047440413.1XP_047296369.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_047440409.1XP_047296365.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_017028026.2XP_016883515.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      P12931
      Related
      ENSP00000362659.2, ENST00000373558.2
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    18. XM_047440412.1XP_047296368.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Related
      ENSP00000362668.2, ENST00000373567.6
    19. XM_047440404.1XP_047296360.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791812.1 Reference GRCh38.p14 PATCHES

      Range
      254201..315552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333285.1XP_054189260.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_054333286.1XP_054189261.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_054333293.1XP_054189268.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_054333281.1XP_054189256.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_054333288.1XP_054189263.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_054333297.1XP_054189272.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_054333291.1XP_054189266.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_054333294.1XP_054189269.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_054333282.1XP_054189257.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_054333287.1XP_054189262.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_054333296.1XP_054189271.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_054333292.1XP_054189267.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_054333283.1XP_054189258.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_054333289.1XP_054189264.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_054333299.1XP_054189274.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_054333295.1XP_054189270.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_054333284.1XP_054189259.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    18. XM_054333298.1XP_054189273.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    19. XM_054333290.1XP_054189265.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      39068774..39130114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323903.1XP_054179878.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_054323904.1XP_054179879.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_054323911.1XP_054179886.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_054323899.1XP_054179874.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_054323906.1XP_054179881.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_054323915.1XP_054179890.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_054323909.1XP_054179884.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_054323912.1XP_054179887.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_054323900.1XP_054179875.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_054323905.1XP_054179880.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_054323914.1XP_054179889.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_054323910.1XP_054179885.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_054323901.1XP_054179876.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_054323907.1XP_054179882.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_054323917.1XP_054179892.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_054323913.1XP_054179888.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_054323902.1XP_054179877.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    18. XM_054323916.1XP_054179891.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    19. XM_054323908.1XP_054179883.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8