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Src Rous sarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 20779, updated on 5-Jan-2023

Summary

Official Symbol
Srcprovided by MGI
Official Full Name
Rous sarcoma oncogeneprovided by MGI
Primary source
MGI:MGI:98397
See related
Ensembl:ENSMUSG00000027646 AllianceGenome:MGI:98397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pp60c-src
Summary
Enables several functions, including connexin binding activity; ephrin receptor binding activity; and scaffold protein binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of signal transduction; and protein destabilization. Acts upstream of or within several processes, including animal organ development; cellular response to growth factor stimulus; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 49.0), colon adult (RPKM 48.4) and 23 other tissues See more
Orthologs
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Genomic context

See Src in Genome Data Viewer
Location:
2 H1; 2 78.35 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157265790..157313758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157423906..157471838)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39974 Neighboring gene mannosidase, beta A, lysosomal-like Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables connexin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin-activated signaling pathway involved in heart process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to peptide hormone stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to progesterone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within osteoclast development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of podosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of podosome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in primary ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell projection assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase Src; neuronal proto-oncogene tyrosine-protein kinase Src
Names
p60-Src
proto-oncogene c-Src
NP_001020566.1
NP_033297.2
XP_006499126.1
XP_006499128.1
XP_006499129.1
XP_011237704.1
XP_011237705.1
XP_011237706.1
XP_030104859.1
XP_030104861.1
XP_030104862.1
XP_036015972.1
XP_036015973.1
XP_036015974.1
XP_036015976.1
XP_036015977.1
XP_036015978.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025395.3NP_001020566.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    See identical proteins and their annotated locations for NP_001020566.1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    Consensus CDS
    CCDS16978.1
    UniProtKB/Swiss-Prot
    P05480, Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2, F8WI90
    Related
    ENSMUSP00000029175.8, ENSMUST00000029175.14
    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. NM_001412682.1NP_001399611.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  3. NM_001412683.1NP_001399612.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  4. NM_001412684.1NP_001399613.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  5. NM_001412685.1NP_001399614.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  6. NM_001412686.1NP_001399615.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  7. NM_001412687.1NP_001399616.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
  8. NM_001412688.1NP_001399617.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
  9. NM_001412689.1NP_001399618.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
  10. NM_001412690.1NP_001399619.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
  11. NM_001412691.1NP_001399620.1  proto-oncogene tyrosine-protein kinase Src isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
  12. NM_001412693.1NP_001399622.1  proto-oncogene tyrosine-protein kinase Src isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672259
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
  13. NM_009271.4NP_033297.2  proto-oncogene tyrosine-protein kinase Src isoform 1

    See identical proteins and their annotated locations for NP_033297.2

    Status: VALIDATED

    Source sequence(s)
    AL672259
    Consensus CDS
    CCDS38305.1
    UniProtKB/Swiss-Prot
    P05480
    UniProtKB/TrEMBL
    A0A6P7QXG6, A0A8C6IAZ6
    Related
    ENSMUSP00000090237.5, ENSMUST00000092576.11
    Conserved Domains (3) summary
    cd10365
    Location:152252
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87148
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:265541
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157265790..157313758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249002.2XP_030104862.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X3

    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. XM_011239404.3XP_011237706.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237706.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  3. XM_006499066.4XP_006499129.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499129.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  4. XM_036160081.1XP_036015974.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X2

    Related
    ENSMUSP00000105155.2, ENSMUST00000109529.2
    Conserved Domains (3) summary
    cd10365
    Location:152252
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87148
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:265541
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  5. XM_036160085.1XP_036015978.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  6. XM_030248999.1XP_030104859.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  7. XM_036160083.1XP_036015976.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
    Related
    ENSMUSP00000105159.2, ENSMUST00000109533.8
    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  8. XM_036160080.1XP_036015973.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X2

    Conserved Domains (3) summary
    cd10365
    Location:152252
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87148
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:265541
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  9. XM_011239403.3XP_011237705.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237705.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  10. XM_036160084.1XP_036015977.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/Swiss-Prot
    Q2M4I4
    UniProtKB/TrEMBL
    A0A6P7QPX1, A0A8C6I7Z2
    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  11. XM_006499063.4XP_006499126.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499126.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  12. XM_011239402.3XP_011237704.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_011237704.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  13. XM_036160079.1XP_036015972.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X2

    Conserved Domains (3) summary
    cd10365
    Location:152252
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87148
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:265541
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  14. XM_030249001.2XP_030104861.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X3

    Conserved Domains (3) summary
    cd10365
    Location:146246
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87142
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:259535
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  15. XM_006499065.3XP_006499128.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

    See identical proteins and their annotated locations for XP_006499128.1

    UniProtKB/TrEMBL
    A0A6P7QMS3
    Conserved Domains (3) summary
    cd10365
    Location:163263
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:87159
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:276552
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src