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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6714, updated on 10-May-2020

Summary

Official Symbol
SRCprovided by HGNC
Official Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:11283
See related
Ensembl:ENSG00000197122 MIM:190090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASV; SRC1; THC6; c-SRC; p60-Src
Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 19.0), testis (RPKM 19.0) and 25 other tissues See more
Orthologs

Genomic context

See SRC in Genome Data Viewer
Location:
20q11.23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (37344685..37406050)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35973088..36033835)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC105372606 Neighboring gene ribosomal protein L7a pseudogene 14 Neighboring gene BLCAP apoptosis inducing factor Neighboring gene neuronatin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Thrombocytopenia 6
MedGen: C4310789 OMIM: 616937 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of retinopathy in individuals without diabetes.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 activates SRC in monocyte derived dendritic cells PubMed
Knockdown of c-SRC tyrosine kinase by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
env Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
Nef nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
nef High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions PubMed
nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
nef The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef PubMed
Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed
tat HIV-1 Tat and cocaine treatment upregulates the expreesion of phophorylated SRC protein in human pulmonary arterial smooth muscle cells PubMed
tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed
tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
tat HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
BMP receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
connexin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding TAS
Traceable Author Statement
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
adherens junction organization IEA
Inferred from Electronic Annotation
more info
 
angiotensin-activated signaling pathway involved in heart process ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to progesterone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
entry of bacterium into host cell TAS
Traceable Author Statement
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
odontogenesis IEA
Inferred from Electronic Annotation
more info
 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of integrin activation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IC
Inferred by Curator
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
positive regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
primary ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
progesterone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization IEA
Inferred from Electronic Annotation
more info
 
regulation of bone resorption TAS
Traceable Author Statement
more info
PubMed 
regulation of caveolin-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell projection assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
response to acidic pH IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to mineralocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
signal complex assembly TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
transcytosis IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uterus development IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin filament IEA
Inferred from Electronic Annotation
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic specialization, intracellular component IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
proto-oncogene c-Src
protooncogene SRC, Rous sarcoma
tyrosine kinase pp60c-src
tyrosine-protein kinase SRC-1
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NP_005408.1
NP_938033.1
XP_011527315.1
XP_016883513.1
XP_016883514.1
XP_016883515.1
XP_016883516.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023033.1 RefSeqGene

    Range
    6444..65748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1018

mRNA and Protein(s)

  1. NM_005417.4NP_005408.1  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_005408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF272982, BC051270, CD364525
    Consensus CDS
    CCDS13294.1
    UniProtKB/Swiss-Prot
    P12931
    Related
    ENSP00000350941.4, ENST00000358208.8
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. NM_198291.3NP_938033.1  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_938033.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL133293, AW135290, BC051270, CD364525, HY016645
    Consensus CDS
    CCDS13294.1
    UniProtKB/Swiss-Prot
    P12931
    Related
    ENSP00000362680.2, ENST00000373578.6
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    37344685..37406050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028026.1XP_016883515.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. XM_017028024.1XP_016883513.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  3. XM_017028025.1XP_016883514.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  4. XM_011529013.2XP_011527315.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    See identical proteins and their annotated locations for XP_011527315.1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  5. XM_017028027.2XP_016883516.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Related
    ENSP00000362659.2, ENST00000373558.2
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
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