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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6714, updated on 25-Nov-2021

Summary

Official Symbol
SRCprovided by HGNC
Official Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:11283
See related
Ensembl:ENSG00000197122 MIM:190090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASV; SRC1; THC6; c-SRC; p60-Src
Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 19.0), testis (RPKM 19.0) and 25 other tissues See more
Orthologs
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Genomic context

See SRC in Genome Data Viewer
Location:
20q11.23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (37344690..37406050)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35973102..36034453)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC105372606 Neighboring gene ribosomal protein L7a pseudogene 14 Neighboring gene BLCAP apoptosis inducing factor Neighboring gene neuronatin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Colorectal cancer
MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Genome-wide association study of retinopathy in individuals without diabetes.
GeneReviews: Not available
Thrombocytopenia 6
MedGen: C4310789 OMIM: 616937 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 activates SRC in monocyte derived dendritic cells PubMed
Knockdown of c-SRC tyrosine kinase by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
env Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
Nef nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
nef High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions PubMed
nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
nef The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef PubMed
Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed
tat HIV-1 Tat and cocaine treatment upregulates the expreesion of phophorylated SRC protein in human pulmonary arterial smooth muscle cells PubMed
tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed
tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
tat HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner PubMed
tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables BMP receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables connexin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding TAS
Traceable Author Statement
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables phospholipase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in T cell costimulation TAS
Traceable Author Statement
more info
 
involved_in activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 
involved_in angiotensin-activated signaling pathway involved in heart process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to peptide hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to progesterone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in entry of bacterium into host cell TAS
Traceable Author Statement
more info
 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intestinal epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration TAS
Traceable Author Statement
more info
 
involved_in macroautophagy TAS
Traceable Author Statement
more info
 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of integrin activation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in primary ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
involved_in progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in progesterone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bone resorption TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of caveolin-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell projection assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
involved_in response to acidic pH IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mineralocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
involved_in transcytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in uterus development IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in podosome IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic specialization, intracellular component IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
proto-oncogene c-Src
protooncogene SRC, Rous sarcoma
tyrosine kinase pp60c-src
tyrosine-protein kinase SRC-1
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NP_005408.1
NP_938033.1
XP_011527315.1
XP_016883513.1
XP_016883514.1
XP_016883515.1
XP_016883516.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023033.1 RefSeqGene

    Range
    6444..65748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1018

mRNA and Protein(s)

  1. NM_005417.5NP_005408.1  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_005408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL034422, AL133293, KF456893
    Consensus CDS
    CCDS13294.1
    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. NM_198291.3NP_938033.1  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_938033.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL133293, AW135290, BC051270, CD364525, HY016645
    Consensus CDS
    CCDS13294.1
    UniProtKB/Swiss-Prot
    P12931
    Related
    ENSP00000362680.2, ENST00000373578.7
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    37344690..37406050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028026.1XP_016883515.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. XM_017028024.1XP_016883513.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  3. XM_017028025.1XP_016883514.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  4. XM_011529013.2XP_011527315.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    See identical proteins and their annotated locations for XP_011527315.1

    UniProtKB/Swiss-Prot
    P12931
    Conserved Domains (3) summary
    cd10365
    Location:147247
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88143
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:260536
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  5. XM_017028027.2XP_016883516.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    P12931
    Related
    ENSP00000362659.2, ENST00000373558.2
    Conserved Domains (3) summary
    cd10365
    Location:153253
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:88149
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:266542
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
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