BID BH3 interacting domain death agonist [Homo sapiens (human)] - Gene

Summary

Official Symbol: BIDprovided by HGNC
Official Full Name: BH3 interacting domain death agonistprovided by HGNC
Primary source: HGNC:HGNC:1050
See related: Ensembl:ENSG00000015475 MIM:601997; AllianceGenome:HGNC:1050
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FP497
Summary: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]
Expression: Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q11.21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (17734138..17774665, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (18401873..18442340, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (18216904..18257431, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA sequencing comparing centenarian and middle-aged women lymphoblastoid cell lines identifies age-related dysregulated expression of genes encoding selenoproteins, heat shock proteins, CD99, and BID.
Title: RNA sequencing comparing centenarian and middle-aged women lymphoblastoid cell lines identifies age-related dysregulated expression of genes encoding selenoproteins, heat shock proteins, CD99, and BID.
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.
Title: BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.
Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.
Title: Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.
BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.
Title: BCL-2-family protein tBID can act as a BAX-like effector of apoptosis.
BID and the alpha-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
Title: BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
The findings suggest that the cleaved Bid protein acts as an amplifier of apoptotic signaling through mitochondria, thus enhancing the activity of cysteine cathepsins following stefin B degradation.
Title: Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.
Differential roles for FL_BID and t-BID in Burkitt's lymphoma during apoptosis. There is a functional cooperation between BAK and BAX during VT-1-induced apoptosis and, unexpectedly, that activation of caspase-8 and production of t-BID were not mandatory for initiation of the cell death process.
Title: Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.
These results identify a role for Bid in homeostatic mitochondrial cristae reorganization, that we link to human cardiac disease.
Title: Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
results suggest that histone modifications in the promoter region of miR-500a may be responsible for the increased expression of miR-500a in Hepatocellular carcinoma (HCC), which promotes cancer progression by targeting BID, indicating that miR-500a may be a potential prognostic predictor and therapeutic target for HCC patients.
Title: MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.
The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.
Title: The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.

Submit: New GeneRIF Correction See all GeneRIFs (154)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of BH3 interacting domain death agonist (BID) in Jurkat cells	PubMed
	tat	FasL-induced cleavage of BID/p22 and BCL2 is inhibited in HIV-1 Tat101-expressing Jurkat cells	PubMed
Vpr	vpr	HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on BID activation in THP-1 cells	PubMed
	vpr	Inhibition of MEK1,2 impairs HIV-1 Vpr-induced BID cleavage	PubMed
	vpr	HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation	PubMed
	vpr	Overexpression of BID is induced by HIV-1 Vpr in the transfected 293T cells	PubMed
retropepsin	gag-pol	HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S16 (e-PCR)
- UniSTS:155756

SHGC-36512 (e-PCR)
- UniSTS:4995

D11S3114 (e-PCR)
- UniSTS:152207

p1087L10.C1 (e-PCR)
- UniSTS:146577

RH92974 (e-PCR)
- UniSTS:89764

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase regulator activity involved in apoptotic process	TAS Traceable Author Statement more info	PubMed
enables death receptor binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info	PubMed
involved_in hepatocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial outer membrane permeabilization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction in response to DNA damage	TAS Traceable Author Statement more info	PubMed
involved_in supramolecular fiber organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BH3-interacting domain death agonist

Names: Human BID coding sequence; apoptic death agonist; desmocollin type 4; p22 BID

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001196.4 → NP_001187.1 BH3-interacting domain death agonist isoform 2

See identical proteins and their annotated locations for NP_001187.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, BM561391

Consensus CDS

CCDS13748.1

UniProtKB/Swiss-Prot

P55957, Q549M7, Q71T04, Q7Z4M9, Q8IY86

UniProtKB/TrEMBL

A8ASI8, B3KT21

Related

ENSP00000480414.1, ENST00000622694.5

Conserved Domains (1) summary

pfam06393
Location:3 → 192

BID; BH3 interacting domain (BID)
NM_001244567.1 → NP_001231496.1 BH3-interacting domain death agonist isoform 2

See identical proteins and their annotated locations for NP_001231496.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, EU678294

Consensus CDS

CCDS13748.1

UniProtKB/Swiss-Prot

P55957, Q549M7, Q71T04, Q7Z4M9, Q8IY86

UniProtKB/TrEMBL

A8ASI8, B3KT21

Related

ENSP00000449236.1, ENST00000551952.5

Conserved Domains (1) summary

pfam06393
Location:3 → 192

BID; BH3 interacting domain (BID)
NM_001244569.1 → NP_001231498.1 BH3-interacting domain death agonist isoform 3

See identical proteins and their annotated locations for NP_001231498.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, CN277529, DA158889

Consensus CDS

CCDS13749.1

UniProtKB/TrEMBL

B2ZP79

Related

ENSP00000477773.1, ENST00000614949.4

Conserved Domains (1) summary

pfam06393
Location:1 → 96

BID; BH3 interacting domain (BID)
NM_001244570.1 → NP_001231499.1 BH3-interacting domain death agonist isoform 3

See identical proteins and their annotated locations for NP_001231499.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, DA007047, DA158889

Consensus CDS

CCDS13749.1

UniProtKB/TrEMBL

B2ZP79

Related

ENSP00000382667.1, ENST00000399765.5

Conserved Domains (1) summary

pfam06393
Location:1 → 96

BID; BH3 interacting domain (BID)
NM_001244572.1 → NP_001231501.1 BH3-interacting domain death agonist isoform 3

See identical proteins and their annotated locations for NP_001231501.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks two alternate coding exons compared to variant 1, that causes a frameshift. This variant uses a downstream in-frame start-codon, so the encoded isoform 3 has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, DA274603, DB167767

Consensus CDS

CCDS13749.1

UniProtKB/TrEMBL

B2ZP79

Conserved Domains (1) summary

pfam06393
Location:1 → 96

BID; BH3 interacting domain (BID)
NM_197966.3 → NP_932070.1 BH3-interacting domain death agonist isoform 1

See identical proteins and their annotated locations for NP_932070.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC006285, AF250233, AK094795, BQ775536, DA274603

Consensus CDS

CCDS13747.1

UniProtKB/TrEMBL

B3KT21

Related

ENSP00000318822.7, ENST00000317361.11

Conserved Domains (1) summary

pfam06393
Location:49 → 238

BID; BH3 interacting domain (BID)
NM_197967.2 → NP_932071.1 BH3-interacting domain death agonist isoform 3

See identical proteins and their annotated locations for NP_932071.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' region and uses a downstream start codon, as compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AC006285, AK094795, BC036364, DA158889

Consensus CDS

CCDS13749.1

UniProtKB/TrEMBL

B2ZP79

Related

ENSP00000382669.1, ENST00000399767.6

Conserved Domains (1) summary

pfam06393
Location:1 → 96

BID; BH3 interacting domain (BID)