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    BID BH3 interacting domain death agonist [ Homo sapiens (human) ]

    Gene ID: 637, updated on 5-Mar-2024

    Summary

    Official Symbol
    BIDprovided by HGNC
    Official Full Name
    BH3 interacting domain death agonistprovided by HGNC
    Primary source
    HGNC:HGNC:1050
    See related
    Ensembl:ENSG00000015475 MIM:601997; AllianceGenome:HGNC:1050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FP497
    Summary
    This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    22q11.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (17734138..17774665, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (18401873..18442340, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18216904..18257431, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18623 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:18117540-18117771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:18119788-18120660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:18120661-18121532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:18121533-18122405 Neighboring gene uncharacterized LOC124905160 Neighboring gene BCL2 like 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18628 Neighboring gene Sharpr-MPRA regulatory region 7571 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:18227061-18227681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18232941-18233485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:18236057-18236556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18262368-18263275 Neighboring gene nonconserved acetylation island sequence 74 enhancer Neighboring gene microRNA 3198-1 Neighboring gene VISTA enhancer hs2543 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:18271287-18271499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18277231-18277730 Neighboring gene long intergenic non-protein coding RNA 528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18641 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:18286544-18287743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18291439-18292235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18298181-18298960 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18338757-18339640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:18341985-18342486 Neighboring gene uncharacterized LOC124905075

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    Tat tat HIV-1 Tat upregulates the expression of BH3 interacting domain death agonist (BID) in Jurkat cells PubMed
    tat FasL-induced cleavage of BID/p22 and BCL2 is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    Vpr vpr HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on BID activation in THP-1 cells PubMed
    vpr Inhibition of MEK1,2 impairs HIV-1 Vpr-induced BID cleavage PubMed
    vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
    vpr Overexpression of BID is induced by HIV-1 Vpr in the transfected 293T cells PubMed
    retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC15319, MGC42355

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables death receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of protein localization to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hepatocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial outer membrane permeabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in supramolecular fiber organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    BH3-interacting domain death agonist
    Names
    Human BID coding sequence
    apoptic death agonist
    desmocollin type 4
    p22 BID

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001196.4NP_001187.1  BH3-interacting domain death agonist isoform 2

      See identical proteins and their annotated locations for NP_001187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, BM561391
      Consensus CDS
      CCDS13748.1
      UniProtKB/Swiss-Prot
      P55957, Q549M7, Q71T04, Q7Z4M9, Q8IY86
      UniProtKB/TrEMBL
      A8ASI8, B3KT21
      Related
      ENSP00000480414.1, ENST00000622694.5
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    2. NM_001244567.1NP_001231496.1  BH3-interacting domain death agonist isoform 2

      See identical proteins and their annotated locations for NP_001231496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, EU678294
      Consensus CDS
      CCDS13748.1
      UniProtKB/Swiss-Prot
      P55957, Q549M7, Q71T04, Q7Z4M9, Q8IY86
      UniProtKB/TrEMBL
      A8ASI8, B3KT21
      Related
      ENSP00000449236.1, ENST00000551952.5
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    3. NM_001244569.1NP_001231498.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231498.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, CN277529, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/TrEMBL
      B2ZP79
      Related
      ENSP00000477773.1, ENST00000614949.4
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    4. NM_001244570.1NP_001231499.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231499.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA007047, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/TrEMBL
      B2ZP79
      Related
      ENSP00000382667.1, ENST00000399765.5
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    5. NM_001244572.1NP_001231501.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_001231501.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate coding exons compared to variant 1, that causes a frameshift. This variant uses a downstream in-frame start-codon, so the encoded isoform 3 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA274603, DB167767
      Consensus CDS
      CCDS13749.1
      UniProtKB/TrEMBL
      B2ZP79
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)
    6. NM_197966.3NP_932070.1  BH3-interacting domain death agonist isoform 1

      See identical proteins and their annotated locations for NP_932070.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC006285, AF250233, AK094795, BQ775536, DA274603
      Consensus CDS
      CCDS13747.1
      UniProtKB/TrEMBL
      B3KT21
      Related
      ENSP00000318822.7, ENST00000317361.11
      Conserved Domains (1) summary
      pfam06393
      Location:49238
      BID; BH3 interacting domain (BID)
    7. NM_197967.2NP_932071.1  BH3-interacting domain death agonist isoform 3

      See identical proteins and their annotated locations for NP_932071.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' region and uses a downstream start codon, as compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC006285, AK094795, BC036364, DA158889
      Consensus CDS
      CCDS13749.1
      UniProtKB/TrEMBL
      B2ZP79
      Related
      ENSP00000382669.1, ENST00000399767.6
      Conserved Domains (1) summary
      pfam06393
      Location:196
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      17734138..17774665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      18401873..18442340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)