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Bid BH3 interacting domain death agonist [ Mus musculus (house mouse) ]

Gene ID: 12122, updated on 2-Mar-2019

Summary

Official Symbol
Bidprovided by MGI
Official Full Name
BH3 interacting domain death agonistprovided by MGI
Primary source
MGI:MGI:108093
See related
Ensembl:ENSMUSG00000004446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI875481; AU022477; 2700049M22Rik
Expression
Ubiquitous expression in kidney adult (RPKM 20.6), thymus adult (RPKM 10.6) and 26 other tissues See more
Orthologs

Genomic context

See Bid in Genome Data Viewer
Location:
6 F1; 6 57.02 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (120893119..120917141, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (120843137..120866838, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38889 Neighboring gene BCL2-like 13 (apoptosis facilitator) Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene predicted gene 9878 Neighboring gene predicted gene 4651

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
mitochondrial ATP synthesis coupled electron transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial outer membrane permeabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy in response to ER overload ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane permeability involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
signal transduction in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BH3-interacting domain death agonist
Names
p22 BID

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007544.4NP_031570.2  BH3-interacting domain death agonist

    See identical proteins and their annotated locations for NP_031570.2

    Status: VALIDATED

    Source sequence(s)
    AK077657, AK161235
    Consensus CDS
    CCDS20486.1
    UniProtKB/Swiss-Prot
    P70444
    Related
    ENSMUSP00000004560.5, ENSMUST00000004560.11
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    120893119..120917141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505411.3XP_006505474.1  BH3-interacting domain death agonist isoform X1

    See identical proteins and their annotated locations for XP_006505474.1

    UniProtKB/Swiss-Prot
    P70444
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)
  2. XM_006505410.3XP_006505473.1  BH3-interacting domain death agonist isoform X1

    See identical proteins and their annotated locations for XP_006505473.1

    UniProtKB/Swiss-Prot
    P70444
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)
  3. XM_006505409.2XP_006505472.1  BH3-interacting domain death agonist isoform X1

    See identical proteins and their annotated locations for XP_006505472.1

    UniProtKB/Swiss-Prot
    P70444
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)

Reference GRCm38.p4 129S1/SvImJ

Genomic

  1. NT_039382.4 Reference GRCm38.p4 129S1/SvImJ

    Range
    517736..541471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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