PTPRC protein tyrosine phosphatase receptor type C [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTPRCprovided by HGNC
Official Full Name: protein tyrosine phosphatase receptor type Cprovided by HGNC
Primary source: HGNC:HGNC:9666
See related: Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Expression: Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q31.3-q32.1

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (198638713..198757476)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (197898421..198017392)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (198608170..198726605)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells-Brief Report.
Title: CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells-Brief Report.
Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.
Title: Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.
PTPRC Overexpression Predicts Poor Prognosis and Correlates with Immune Cell Infiltration in Pediatric Acute Myeloid Leukemia.
Title: PTPRC Overexpression Predicts Poor Prognosis and Correlates with Immune Cell Infiltration in Pediatric Acute Myeloid Leukemia.
Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.
Title: Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.
The aberrant expression of CD45 isoforms and levels of sex hormones in systemic lupus erythematosus.
Title: The aberrant expression of CD45 isoforms and levels of sex hormones in systemic lupus erythematosus.
Characteristic CD45RA/CD45RO maturation pattern by flow cytometry associated with the CD45 C77G polymorphism.
Title: Characteristic CD45RA/CD45RO maturation pattern by flow cytometry associated with the CD45 C77G polymorphism.
Exploring blast composition in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: CD45RA and CD371 improve diagnostic value of flow cytometry through assessment of myeloblast heterogeneity and stem cell aberrancy.
Title: Exploring blast composition in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: CD45RA and CD371 improve diagnostic value of flow cytometry through assessment of myeloblast heterogeneity and stem cell aberrancy.
The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling.
Title: The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling.
Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells.
Title: Aberrant activation of the CD45-Wnt signaling axis promotes stemness and therapy resistance in colorectal cancer cells.
Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm.
Title: Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm.

Submit: New GeneRIF Correction See all GeneRIFs (219)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 105 MedGen: C5677005 OMIM: 619924 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of protein tyrosine phosphatase, receptor type C (PTPRC; CD45) in human B cells	PubMed
	env	CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding	PubMed
	env	CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway	PubMed
	env	HIV-1 gp120-induced apoptosis is regulated by CD45 through inducing CD45 association with the HIV coreceptor CXCR4 in T cell lines and peripheral blood mononuclear cells	PubMed
	env	Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with PTPRC; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed
Nef	nef	HIV-1 Nef increases intracellular expression of CD45 and AChE concomitant with release of Nef, CD45, and AChE	PubMed
Tat	tat	HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485636

RH68702 (e-PCR)
- UniSTS:77847

D1S1660 (e-PCR), detects polymorphism
- UniSTS:72252

RH70956 (e-PCR)
- UniSTS:20296

SHGC-76094 (e-PCR)
- UniSTS:40011

AL010096 (e-PCR)
- UniSTS:16486

RH45541 (e-PCR)
- UniSTS:12911

D1S413 (e-PCR), detects polymorphism
- UniSTS:17007

PTPRC_1163 (e-PCR)
- UniSTS:280943

D1S413 (e-PCR), detects polymorphism
- UniSTS:48280

SHGC-150577 (e-PCR)
- UniSTS:173212

SHGC-82196 (e-PCR)
- UniSTS:103094

STS-T93530 (e-PCR)
- UniSTS:27319

RH98676 (e-PCR)
- UniSTS:86990

PMC116441P1 (e-PCR)
- UniSTS:270313

Homology

Homologs of the PTPRC gene: The PTPRC gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 510 organisms have orthologs with human gene PTPRC
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparan sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in DN2 thymocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in bone marrow development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling using intracellular calcium source	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to extracellular stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microglial cell activation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane raft distribution	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of antigen receptor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bleb	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	HDA more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane microdomain	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase C

Names: CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide

NP_001254727.1

EC 3.1.3.48

NP_002829.3

EC 3.1.3.48

NP_563578.2

EC 3.1.3.48

XP_006711535.1

EC 3.1.3.48

XP_006711536.1

EC 3.1.3.48

XP_006711537.1

EC 3.1.3.48

XP_047282337.1

EC 3.1.3.48

XP_047282354.1

EC 3.1.3.48

XP_047282365.1

EC 3.1.3.48

XP_047282371.1

EC 3.1.3.48

XP_047282373.1

EC 3.1.3.48

XP_047282376.1

EC 3.1.3.48

XP_054193920.1

EC 3.1.3.48

XP_054193921.1

EC 3.1.3.48

XP_054193922.1

EC 3.1.3.48

XP_054193923.1

EC 3.1.3.48

XP_054193924.1

EC 3.1.3.48

XP_054193925.1

EC 3.1.3.48

XP_054193926.1

EC 3.1.3.48

XP_054193927.1

EC 3.1.3.48

XP_054193928.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007730.2 RefSeqGene

Range

4946..123382

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_95

mRNA and Protein(s)

NM_001267798.2 → NP_001254727.1 receptor-type tyrosine-protein phosphatase C isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BC031525, DA819314

Consensus CDS

CCDS44291.2

UniProtKB/TrEMBL

M9MML4

Related

ENSP00000405494.3, ENST00000413409.6

Conserved Domains (1) summary

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal
NM_002838.5 → NP_002829.3 receptor-type tyrosine-protein phosphatase C isoform 1 precursor

See identical proteins and their annotated locations for NP_002829.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AA403163, AK292131, BM791051, DA819314, Y00062, Y00638

Consensus CDS

CCDS1397.2

UniProtKB/Swiss-Prot

P08575, X6R433

UniProtKB/TrEMBL

A0A0A0MT22

Related

ENSP00000411355.3, ENST00000442510.8

Conserved Domains (6) summary

PHA03255
Location:81 → 231

PHA03255; BDLF3; Provisional

cd00063
Location:485 → 565

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14557
Location:707 → 907

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:1017 → 1223

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:237 → 295

CD45; Leukocyte receptor CD45
NM_080921.4 → NP_563578.2 receptor-type tyrosine-protein phosphatase C isoform 2 precursor

See identical proteins and their annotated locations for NP_563578.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AA403163, AK292131, BM791051, DA819314, Y00062

Consensus CDS

CCDS1398.2

UniProtKB/Swiss-Prot

P08575

UniProtKB/TrEMBL

X6R433

Related

ENSP00000306782.7, ENST00000348564.11

Conserved Domains (5) summary

cd00063
Location:324 → 404

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14557
Location:546 → 746

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:856 → 1062

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:76 → 134

CD45; Leukocyte receptor CD45

RNA

NR_052021.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs at its 3' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, and there is no support for the existence of this very short protein.

Source sequence(s)

AA904360, BC017863, DA819314

Related

ENST00000367364.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

198638713..198757476

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426381.1 → XP_047282337.1 receptor-type tyrosine-protein phosphatase C isoform X1

UniProtKB/Swiss-Prot

X6R433
XM_047426398.1 → XP_047282354.1 receptor-type tyrosine-protein phosphatase C isoform X3
XM_047426409.1 → XP_047282365.1 receptor-type tyrosine-protein phosphatase C isoform X4
XM_047426415.1 → XP_047282371.1 receptor-type tyrosine-protein phosphatase C isoform X5
XM_006711472.5 → XP_006711535.1 receptor-type tyrosine-protein phosphatase C isoform X2

See identical proteins and their annotated locations for XP_006711535.1

Related

ENSP00000513363.1, ENST00000697631.1

Conserved Domains (6) summary

PHA03255
Location:18 → 183

PHA03255; BDLF3; Provisional

smart00194
Location:604 → 863

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:632 → 863

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:437 → 517

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:189 → 245

CD45; Leukocyte receptor CD45
XM_006711473.4 → XP_006711536.1 receptor-type tyrosine-protein phosphatase C isoform X3

Conserved Domains (6) summary

PHA03255
Location:27 → 165

PHA03255; BDLF3; Provisional

smart00194
Location:586 → 845

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:614 → 845

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:419 → 499

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:171 → 227

CD45; Leukocyte receptor CD45
XM_006711474.4 → XP_006711537.1 receptor-type tyrosine-protein phosphatase C isoform X4

Conserved Domains (5) summary

smart00194
Location:538 → 797

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:566 → 797

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:371 → 451

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:7 → 32

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:123 → 179

CD45; Leukocyte receptor CD45
XM_047426420.1 → XP_047282376.1 receptor-type tyrosine-protein phosphatase C isoform X6
XM_047426417.1 → XP_047282373.1 receptor-type tyrosine-protein phosphatase C isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NW_003315907.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

280445..359708

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

197898421..198017392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337951.1 → XP_054193926.1 receptor-type tyrosine-protein phosphatase C isoform X5
XM_054337945.1 → XP_054193920.1 receptor-type tyrosine-protein phosphatase C isoform X1

UniProtKB/Swiss-Prot

X6R433
XM_054337948.1 → XP_054193923.1 receptor-type tyrosine-protein phosphatase C isoform X3
XM_054337950.1 → XP_054193925.1 receptor-type tyrosine-protein phosphatase C isoform X4
XM_054337946.1 → XP_054193921.1 receptor-type tyrosine-protein phosphatase C isoform X2
XM_054337947.1 → XP_054193922.1 receptor-type tyrosine-protein phosphatase C isoform X3
XM_054337949.1 → XP_054193924.1 receptor-type tyrosine-protein phosphatase C isoform X4
XM_054337953.1 → XP_054193928.1 receptor-type tyrosine-protein phosphatase C isoform X6
XM_054337952.1 → XP_054193927.1 receptor-type tyrosine-protein phosphatase C isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_080922.2: Suppressed sequence

Description

NM_080922.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.