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    PTPRC protein tyrosine phosphatase receptor type C [ Homo sapiens (human) ]

    Gene ID: 5788, updated on 7-Jul-2019

    Summary

    Official Symbol
    PTPRCprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Cprovided by HGNC
    Primary source
    HGNC:HGNC:9666
    See related
    Ensembl:ENSG00000081237 MIM:151460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
    Expression
    Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more
    Orthologs

    Genomic context

    See PTPRC in Genome Data Viewer
    Location:
    1q31.3-q32.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (198638968..198757476)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198608098..198726605)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene PTPRC intron CAGE-defined mid-level expression enhancer Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 3 Neighboring gene MIR181A1 host gene Neighboring gene microRNA 181b-1 Neighboring gene microRNA 181a-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of protein tyrosine phosphatase, receptor type C (PTPRC; CD45) in human B cells PubMed
    env CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env HIV-1 gp120-induced apoptosis is regulated by CD45 through inducing CD45 association with the HIV coreceptor CXCR4 in T cell lines and peripheral blood mononuclear cells PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PTPRC; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
    Nef nef HIV-1 Nef increases intracellular expression of CD45 and AChE concomitant with release of Nef, CD45, and AChE PubMed
    Tat tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
      EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon type I signaling pathways, organism-specific biosystem (from WikiPathways)
      Interferon type I signaling pathways, organism-specific biosystemThe type I IFNs (IFN? family, IFN?, IFN?, IFN? and IFN?) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
      Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystemThis pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus au...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heparan sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DN2 thymocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    bone marrow development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to extracellular stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell adhesion involved in substrate-bound cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-2 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of microglial cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane raft distribution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of antigen receptor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-2 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of JAK-STAT cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    bleb IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane HDA PubMed 
    membrane microdomain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    CD45 antigen
    T200 glycoprotein
    T200 leukocyte common antigen
    protein tyrosine phosphatase, receptor type, c polypeptide
    NP_001254727.1
    NP_002829.3
    NP_563578.2
    XP_006711535.1
    XP_006711536.1
    XP_006711537.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007730.1 RefSeqGene

      Range
      4874..123381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267798.2NP_001254727.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC031525, DA819314
      Consensus CDS
      CCDS44291.2
      UniProtKB/TrEMBL
      M9MML4
      Related
      ENSP00000405494.3, ENST00000413409.6
      Conserved Domains (1) summary
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
    2. NM_002838.5NP_002829.3  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

      See identical proteins and their annotated locations for NP_002829.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA403163, AK292131, BM791051, DA819314, Y00062, Y00638
      Consensus CDS
      CCDS1397.2
      UniProtKB/Swiss-Prot
      P08575
      UniProtKB/TrEMBL
      A0A0A0MT22
      Related
      ENSP00000411355.3, ENST00000442510.8
      Conserved Domains (7) summary
      smart00194
      Location:9441226
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:680911
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:485565
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:393462
      fn3; Fibronectin type III domain
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:237293
      CD45; Leukocyte receptor CD45
      cl25495
      Location:81231
      Endomucin; Endomucin
    3. NM_080921.3NP_563578.2  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

      See identical proteins and their annotated locations for NP_563578.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA403163, AK292131, BM791051, DA819314, Y00062
      Consensus CDS
      CCDS1398.2
      UniProtKB/Swiss-Prot
      P08575
      UniProtKB/TrEMBL
      X6R433
      Related
      ENSP00000306782.7, ENST00000348564.11
      Conserved Domains (5) summary
      smart00194
      Location:491750
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:519750
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:324404
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:76132
      CD45; Leukocyte receptor CD45

    RNA

    1. NR_052021.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs at its 3' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, and there is no support for the existence of this very short protein.
      Source sequence(s)
      AA904360, BC017863, DA819314
      Related
      ENST00000367364.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      198638968..198757476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711473.3XP_006711536.1  receptor-type tyrosine-protein phosphatase C isoform X2

      Conserved Domains (6) summary
      PHA03255
      Location:27165
      PHA03255; BDLF3; Provisional
      smart00194
      Location:586845
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:614845
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:419499
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:171227
      CD45; Leukocyte receptor CD45
    2. XM_006711474.3XP_006711537.1  receptor-type tyrosine-protein phosphatase C isoform X3

      Conserved Domains (5) summary
      smart00194
      Location:538797
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:566797
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:371451
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:123179
      CD45; Leukocyte receptor CD45
    3. XM_006711472.4XP_006711535.1  receptor-type tyrosine-protein phosphatase C isoform X1

      See identical proteins and their annotated locations for XP_006711535.1

      Conserved Domains (6) summary
      PHA03255
      Location:18183
      PHA03255; BDLF3; Provisional
      smart00194
      Location:604863
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:632863
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:437517
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:732
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:189245
      CD45; Leukocyte receptor CD45

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NW_003315907.2 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      280373..359708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080922.2: Suppressed sequence

      Description
      NM_080922.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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