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Ptprc protein tyrosine phosphatase, receptor type, C [ Mus musculus (house mouse) ]

Gene ID: 19264, updated on 22-Nov-2020

Summary

Official Symbol
Ptprcprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Cprovided by MGI
Primary source
MGI:MGI:97810
See related
Ensembl:ENSMUSG00000026395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-; loc; B220; Cd45; L-CA; Ly-5; Lyt-; T200; CD45R; Lyt-4
Expression
Biased expression in spleen adult (RPKM 50.1), thymus adult (RPKM 49.7) and 5 other tissues See more
Orthologs

Genomic context

See Ptprc in Genome Data Viewer
Location:
1 E4; 1 60.73 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (137990597..138103491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (138062859..138175756, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (139959438..140071882, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41959 Neighboring gene microRNA 181b-1 Neighboring gene predicted gene, 34353 Neighboring gene terminal nucleotidyltransferase 2, pseudogene 2 Neighboring gene uncharacterized LOC118567639

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone marrow development ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion involved in substrate-bound cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane raft distribution IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of antigen receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein tyrosine phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
stem cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
bleb ISO
Inferred from Sequence Orthology
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane microdomain IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IGI
Inferred from Genetic Interaction
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
leukocyte common antigen
lymphocyte antigen 5
lymphocyte common antigen
NP_001104786.2
NP_001255215.1
NP_035340.3
XP_006529320.1
XP_006529321.1
XP_006529322.1
XP_006529323.1
XP_006529324.1
XP_006529325.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111316.2NP_001104786.2  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104786.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122903, AC159278, AK054056, BM239381, CA575153, CA577897, CK392851
    Consensus CDS
    CCDS48383.2
    UniProtKB/TrEMBL
    Q8C6Q7, S4R1S4
    Conserved Domains (6) summary
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:27191
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14557
    Location:696896
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:10061211
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:212265
    CD45; Leukocyte receptor CD45
  2. NM_001268286.1NP_001255215.1  receptor-type tyrosine-protein phosphatase C precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks four in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS59542.1
    UniProtKB/TrEMBL
    Q8C6Q7, S4R1M0
    Related
    ENSMUSP00000138275.1, ENSMUST00000182755.7
    Conserved Domains (5) summary
    smart00194
    Location:478737
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:506737
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:311390
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:49102
    CD45; Leukocyte receptor CD45
  3. NM_011210.4NP_035340.3  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    See identical proteins and their annotated locations for NP_035340.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS15330.2
    UniProtKB/TrEMBL
    Q8C6Q7, S4R2V1
    Related
    ENSMUSP00000138800.1, ENSMUST00000182283.7
    Conserved Domains (5) summary
    smart00194
    Location:502761
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:530761
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:335414
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:73126
    CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    137990597..138103491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529258.4XP_006529321.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006529321.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (6) summary
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:27191
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14557
    Location:696896
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:10061211
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:212265
    CD45; Leukocyte receptor CD45
  2. XM_006529259.4XP_006529322.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006529322.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (6) summary
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:27191
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14557
    Location:696896
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:10061211
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:212265
    CD45; Leukocyte receptor CD45
  3. XM_006529262.5XP_006529325.1  receptor-type tyrosine-protein phosphatase C isoform X4

  4. XM_006529260.1XP_006529323.1  receptor-type tyrosine-protein phosphatase C isoform X2

  5. XM_006529261.5XP_006529324.1  receptor-type tyrosine-protein phosphatase C isoform X3

  6. XM_006529257.3XP_006529320.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006529320.1

    UniProtKB/TrEMBL
    S4R1S4
    Related
    ENSMUSP00000138350.1
    Conserved Domains (6) summary
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:27191
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14557
    Location:696896
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:10061211
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:212265
    CD45; Leukocyte receptor CD45
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