Format

Send to:

Choose Destination

PTPRC protein tyrosine phosphatase receptor type C [ Homo sapiens (human) ]

Gene ID: 5788, updated on 11-Sep-2019

Summary

Official Symbol
PTPRCprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Cprovided by HGNC
Primary source
HGNC:HGNC:9666
See related
Ensembl:ENSG00000081237 MIM:151460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Expression
Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more
Orthologs

Genomic context

See PTPRC in Genome Data Viewer
Location:
1q31.3-q32.1
Exon count:
34
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (198638968..198757476)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198608098..198726605)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene PTPRC intron CAGE-defined mid-level expression enhancer Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 3 Neighboring gene MIR181A1 host gene Neighboring gene microRNA 181b-1 Neighboring gene microRNA 181a-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of protein tyrosine phosphatase, receptor type C (PTPRC; CD45) in human B cells PubMed
env CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env HIV-1 gp120-induced apoptosis is regulated by CD45 through inducing CD45 association with the HIV coreceptor CXCR4 in T cell lines and peripheral blood mononuclear cells PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PTPRC; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Nef nef HIV-1 Nef increases intracellular expression of CD45 and AChE concomitant with release of Nef, CD45, and AChE PubMed
Tat tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
  • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    BCR signaling pathway, organism-specific biosystem
    BCR signaling pathway
  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
    EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interferon type I signaling pathways, organism-specific biosystem (from WikiPathways)
    Interferon type I signaling pathways, organism-specific biosystemThe type I IFNs (IFN? family, IFN?, IFN?, IFN? and IFN?) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
    Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
  • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
    Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystemThis pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus au...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells
  • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD8+ T cells, organism-specific biosystem
    TCR signaling in naive CD8+ T cells

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
DN2 thymocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
T cell activation TAS
Traceable Author Statement
more info
PubMed 
T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
bone marrow development IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion involved in substrate-bound cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-2 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft distribution ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of antigen receptor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-2 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of JAK-STAT cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
bleb IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
membrane microdomain ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
CD45 antigen
T200 glycoprotein
T200 leukocyte common antigen
protein tyrosine phosphatase, receptor type, c polypeptide
NP_001254727.1
NP_002829.3
NP_563578.2
XP_006711535.1
XP_006711536.1
XP_006711537.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007730.1 RefSeqGene

    Range
    4946..123381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267798.2NP_001254727.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC031525, DA819314
    Consensus CDS
    CCDS44291.2
    UniProtKB/TrEMBL
    M9MML4
    Related
    ENSP00000405494.3, ENST00000413409.6
    Conserved Domains (1) summary
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
  2. NM_002838.5NP_002829.3  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_002829.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA403163, AK292131, BM791051, DA819314, Y00062, Y00638
    Consensus CDS
    CCDS1397.2
    UniProtKB/Swiss-Prot
    P08575
    UniProtKB/TrEMBL
    A0A0A0MT22
    Related
    ENSP00000411355.3, ENST00000442510.8
    Conserved Domains (7) summary
    smart00194
    Location:9441226
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:680911
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:485565
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:393462
    fn3; Fibronectin type III domain
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:237293
    CD45; Leukocyte receptor CD45
    cl25495
    Location:81231
    Endomucin; Endomucin
  3. NM_080921.3NP_563578.2  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    See identical proteins and their annotated locations for NP_563578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA403163, AK292131, BM791051, DA819314, Y00062
    Consensus CDS
    CCDS1398.2
    UniProtKB/Swiss-Prot
    P08575
    UniProtKB/TrEMBL
    X6R433
    Related
    ENSP00000306782.7, ENST00000348564.11
    Conserved Domains (5) summary
    smart00194
    Location:491750
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:519750
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324404
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:76132
    CD45; Leukocyte receptor CD45

RNA

  1. NR_052021.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs at its 3' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, and there is no support for the existence of this very short protein.
    Source sequence(s)
    AA904360, BC017863, DA819314
    Related
    ENST00000367364.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    198638968..198757476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711473.3XP_006711536.1  receptor-type tyrosine-protein phosphatase C isoform X2

    Conserved Domains (6) summary
    PHA03255
    Location:27165
    PHA03255; BDLF3; Provisional
    smart00194
    Location:586845
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:614845
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:419499
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:171227
    CD45; Leukocyte receptor CD45
  2. XM_006711474.3XP_006711537.1  receptor-type tyrosine-protein phosphatase C isoform X3

    Conserved Domains (5) summary
    smart00194
    Location:538797
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:566797
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:371451
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:123179
    CD45; Leukocyte receptor CD45
  3. XM_006711472.4XP_006711535.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006711535.1

    Conserved Domains (6) summary
    PHA03255
    Location:18183
    PHA03255; BDLF3; Provisional
    smart00194
    Location:604863
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:632863
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437517
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:189245
    CD45; Leukocyte receptor CD45

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315907.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    280373..359708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080922.2: Suppressed sequence

    Description
    NM_080922.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center