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PTPRC protein tyrosine phosphatase receptor type C [ Homo sapiens (human) ]

Gene ID: 5788, updated on 24-Nov-2020

Summary

Official Symbol
PTPRCprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Cprovided by HGNC
Primary source
HGNC:HGNC:9666
See related
Ensembl:ENSG00000081237 MIM:151460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Expression
Biased expression in lymph node (RPKM 119.6), appendix (RPKM 101.8) and 10 other tissues See more
Orthologs

Genomic context

See PTPRC in Genome Data Viewer
Location:
1q31.3-q32.1
Exon count:
34
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (198639025..198757476)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198608098..198726605)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10450 Neighboring gene PTPRC intron CAGE-defined mid-level expression enhancer Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 3 Neighboring gene MIR181A1 host gene Neighboring gene microRNA 181b-1 Neighboring gene microRNA 181a-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Hepatitis c virus, susceptibility to
MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
Compare labs
Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive
MedGen: C1837028 OMIM: 608971 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of protein tyrosine phosphatase, receptor type C (PTPRC; CD45) in human B cells PubMed
env CD4(+)CD45RO(+) cells display high HIV-1 gp120-binding capacity, whereas CD4(+)CD45RO(-) cells show undetectable HIV-1 gp120 binding PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env HIV-1 gp120-induced apoptosis is regulated by CD45 through inducing CD45 association with the HIV coreceptor CXCR4 in T cell lines and peripheral blood mononuclear cells PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PTPRC; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Nef nef HIV-1 Nef increases intracellular expression of CD45 and AChE concomitant with release of Nef, CD45, and AChE PubMed
Tat tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
DN2 thymocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
T cell activation TAS
Traceable Author Statement
more info
PubMed 
T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
bone marrow development IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion involved in substrate-bound cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft distribution ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of antigen receptor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of isotype switching to IgG isotypes IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bleb IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
membrane microdomain ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
CD45 antigen
T200 glycoprotein
T200 leukocyte common antigen
protein tyrosine phosphatase, receptor type, c polypeptide
NP_001254727.1
NP_002829.3
NP_563578.2
XP_006711535.1
XP_006711536.1
XP_006711537.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007730.1 RefSeqGene

    Range
    4946..123381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267798.2NP_001254727.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC031525, DA819314
    Consensus CDS
    CCDS44291.2
    UniProtKB/TrEMBL
    M9MML4
    Related
    ENSP00000405494.3, ENST00000413409.6
    Conserved Domains (1) summary
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
  2. NM_002838.5NP_002829.3  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_002829.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA403163, AK292131, BM791051, DA819314, Y00062, Y00638
    Consensus CDS
    CCDS1397.2
    UniProtKB/Swiss-Prot
    P08575
    UniProtKB/TrEMBL
    A0A0A0MT22
    Related
    ENSP00000411355.3, ENST00000442510.8
    Conserved Domains (6) summary
    PHA03255
    Location:81231
    PHA03255; BDLF3; Provisional
    cd00063
    Location:485565
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:707907
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:10171223
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:237295
    CD45; Leukocyte receptor CD45
  3. NM_080921.4NP_563578.2  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    See identical proteins and their annotated locations for NP_563578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA403163, AK292131, BM791051, DA819314, Y00062
    Consensus CDS
    CCDS1398.2
    UniProtKB/Swiss-Prot
    P08575
    UniProtKB/TrEMBL
    X6R433
    Related
    ENSP00000306782.7, ENST00000348564.11
    Conserved Domains (5) summary
    cd00063
    Location:324404
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:546746
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:8561062
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:76134
    CD45; Leukocyte receptor CD45

RNA

  1. NR_052021.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs at its 3' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, and there is no support for the existence of this very short protein.
    Source sequence(s)
    AA904360, BC017863, DA819314
    Related
    ENST00000367364.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    198639025..198757476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711473.3XP_006711536.1  receptor-type tyrosine-protein phosphatase C isoform X2

    Conserved Domains (6) summary
    PHA03255
    Location:27165
    PHA03255; BDLF3; Provisional
    smart00194
    Location:586845
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:614845
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:419499
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:171227
    CD45; Leukocyte receptor CD45
  2. XM_006711474.3XP_006711537.1  receptor-type tyrosine-protein phosphatase C isoform X3

    Conserved Domains (5) summary
    smart00194
    Location:538797
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:566797
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:371451
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:123179
    CD45; Leukocyte receptor CD45
  3. XM_006711472.4XP_006711535.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006711535.1

    Conserved Domains (6) summary
    PHA03255
    Location:18183
    PHA03255; BDLF3; Provisional
    smart00194
    Location:604863
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:632863
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437517
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:732
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:189245
    CD45; Leukocyte receptor CD45

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315907.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    280445..359708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080922.2: Suppressed sequence

    Description
    NM_080922.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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