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    OGN osteoglycin [ Homo sapiens (human) ]

    Gene ID: 4969, updated on 5-Mar-2024

    Summary

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    Official Symbol
    OGNprovided by HGNC
    Official Full Name
    osteoglycinprovided by HGNC
    Primary source
    HGNC:HGNC:8126
    See related
    Ensembl:ENSG00000106809 MIM:602383; AllianceGenome:HGNC:8126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OG; OIF; SLRR3A
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    9q22.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (92383268..92404699, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (104549769..104571196, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95145550..95166981, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:95086914-95087802 Neighboring gene nucleolar protein 8 Neighboring gene phagosome assembly factor 1 pseudogene Neighboring gene centromere protein P Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109628 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_109638 Neighboring gene osteomodulin Neighboring gene asporin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events. Al-Sharify D, et al. Atherosclerosis, 2022 Aug. PMID 35850021
    2. The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death. Tengryd C, et al. Atherosclerosis, 2020 Nov. PMID 33032238
    3. Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. Hu X, et al. EBioMedicine, 2018 Aug. PMID 30037719, Free PMC Article
    4. Low Levels of Plasma Osteoglycin in Patients with Complex Coronary Lesions. Seki T, et al. J Atheroscler Thromb, 2018 Nov 1. PMID 29503411, Free PMC Article
    5. Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. Hu X, et al. J Exp Clin Cancer Res, 2018 Mar 2. PMID 29499765, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
      Title: Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
    2. Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.
      Title: Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.
    3. Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells.
      Title: Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells.
    4. Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study.
      Title: Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study.
    5. The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death.
      Title: The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death.
    6. Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
      Title: Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
    7. Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
      Title: Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
    8. Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.
      Title: Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.
    9. serum concentration not associated with carotid atherosclerosis plaque in essential hypertensive patients
      Title: Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients.
    10. There is a positive association between OGN level and prolonged survival in CRC. OGN plays a restrictive role in colorectal cancer progression by reduced activation of EGFR/AKT/Zeb-1.
      Title: Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586P2421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in articular cartilage development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in lysosomal lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mimecan
    Names
    corneal keratan sulfate proteoglycan
    mimecan proteoglycan
    osteoinductive factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014057.5 → NP_054776.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_054776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AF086912, AF100758, AK295433, AL137848, BM679549
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774, Q6FIB0, Q9UF90, Q9UNK5
      UniProtKB/TrEMBL
      A8K0R3, Q7Z532
      Related
      ENSP00000364711.5, ENST00000375561.10
      Conserved Domains (2) summary
      sd00033
      Location:123 → 144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 225
      LRR_8; Leucine rich repeat

    2. NM_024416.4 → NP_077727.3  mimecan isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.
      Source sequence(s)
      AF086912, AK295433, AL137848, BC095443, BG772245, BM679549
      UniProtKB/TrEMBL
      B4DI63, Q7Z532
      Conserved Domains (3) summary
      sd00033
      Location:181 → 202
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:181 → 218
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:201 → 283
      LRR_8; Leucine rich repeat

    3. NM_033014.4 → NP_148935.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_148935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AL137848, BC095443, BG772245, BM679549, CB268982
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774, Q6FIB0, Q9UF90, Q9UNK5
      UniProtKB/TrEMBL
      A8K0R3, Q7Z532
      Related
      ENSP00000262551.4, ENST00000262551.8
      Conserved Domains (2) summary
      sd00033
      Location:123 → 144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143 → 225
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      92383268..92404699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791788.1 Reference GRCh38.p14 PATCHES

      Range
      217997..239428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      104549769..104571196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20774.1 GenPept UniProtKB/Swiss-Prot:P20774

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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