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Ogn osteoglycin [ Mus musculus (house mouse) ]

Gene ID: 18295, updated on 19-Feb-2023

Summary

Official Symbol
Ognprovided by MGI
Official Full Name
osteoglycinprovided by MGI
Primary source
MGI:MGI:109278
See related
Ensembl:ENSMUSG00000021390 AllianceGenome:MGI:109278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OG; OIF; SLRR3A; mimecan; mimican; 3110079A16Rik
Summary
Predicted to enable growth factor activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in negative regulation of smooth muscle cell proliferation. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and skeleton. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 41.4), limb E14.5 (RPKM 40.9) and 15 other tissues See more
Orthologs
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Genomic context

See Ogn in Genome Data Viewer
Location:
13; 13 A5
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49761491..49777977)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49608015..49624501)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene asporin Neighboring gene osteomodulin Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucine-tRNA synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in articular cartilage development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008760.5NP_032786.1  mimecan precursor

    See identical proteins and their annotated locations for NP_032786.1

    Status: VALIDATED

    Source sequence(s)
    AK160760, AK163772, BB630217, BE629408
    Consensus CDS
    CCDS26505.1
    UniProtKB/Swiss-Prot
    Q62000
    UniProtKB/TrEMBL
    Q543C5
    Related
    ENSMUSP00000021822.6, ENSMUST00000021822.7
    Conserved Domains (4) summary
    cd00116
    Location:143275
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:123144
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:143225
    LRR_8; Leucine rich repeat
    pfam15376
    Location:61158
    DUF4603; Domain of unknown function (DUF4603)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49761491..49777977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)