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    BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens (human) ]

    Gene ID: 330, updated on 3-Apr-2024

    Summary

    Official Symbol
    BIRC3provided by HGNC
    Official Full Name
    baculoviral IAP repeat containing 3provided by HGNC
    Primary source
    HGNC:HGNC:591
    See related
    Ensembl:ENSG00000023445 MIM:601721; AllianceGenome:HGNC:591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2
    Summary
    This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in lymph node (RPKM 48.6), appendix (RPKM 43.1) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BIRC3 in Genome Data Viewer
    Location:
    11q22.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (102317484..102339403)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (102319603..102341520)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102188215..102210134)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902739 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:102187662-102188861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5438 Neighboring gene RNA, U6 small nuclear 952, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5440 Neighboring gene baculoviral IAP repeat containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5441 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102245101-102245686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:102245687-102246271 Neighboring gene transmembrane protein 123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5442 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:102299689-102299866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3861

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of baculoviral IAP repeat containing 3 (BIRC3) expression as compared to untreated control PubMed
    Tat tat HIV-1 Tat101 upregulates the expression of baculoviral IAP repeat-containing 3 (BIRC3; C-IAP2) in Jurkat cells PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including MIHC, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vpr vpr HIV-1 Vpr [TRAF1 and TRAF2 downregulation] is counteracted by BIRC3 (c-IAP-2) in THP-1 cells and monocytes PubMed
    vpr Anti-apoptotic proteins BIRC3 (cIAP1) and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of RIG-I signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of necroptotic process TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 3
    Names
    IAP homolog C
    RING finger protein 49
    RING-type E3 ubiquitin transferase BIRC3
    TNFR2-TRAF signaling complex protein
    TNFR2-TRAF-signaling complex protein 1
    apoptosis inhibitor 2
    cellular inhibitor of apoptosis 2
    inhibitor of apoptosis protein 1
    mammalian IAP homolog C
    NP_001156.1
    NP_892007.1
    XP_054224588.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065365.1 RefSeqGene

      Range
      5001..26920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1423

    mRNA and Protein(s)

    1. NM_001165.5NP_001156.1  baculoviral IAP repeat-containing protein 3

      See identical proteins and their annotated locations for NP_001156.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA805622, AA873008, AF070674, AI880555, BC037420, BE907592, BG569841, BU428906, BX415415, BX475964, U37546, U45878
      Consensus CDS
      CCDS8315.1
      UniProtKB/Swiss-Prot
      Q13489, Q16628, Q9HC27, Q9UP46
      UniProtKB/TrEMBL
      A0A669KBC7
      Related
      ENSP00000263464.4, ENST00000263464.9
      Conserved Domains (4) summary
      smart00238
      Location:254322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:441530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      pfam13920
      Location:553598
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl21463
      Location:377411
      UBA_like_SF; UBA domain-like superfamily
    2. NM_182962.3NP_892007.1  baculoviral IAP repeat-containing protein 3

      See identical proteins and their annotated locations for NP_892007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA805622, AA873008, AI880555, BC037420, BE907592, BG569841, BX415415, L49432, U45878
      Consensus CDS
      CCDS8315.1
      UniProtKB/Swiss-Prot
      Q13489, Q16628, Q9HC27, Q9UP46
      UniProtKB/TrEMBL
      A0A669KBC7
      Related
      ENSP00000432907.1, ENST00000532808.5
      Conserved Domains (4) summary
      smart00238
      Location:254322
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:441530
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      pfam13920
      Location:553598
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl21463
      Location:377411
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      102317484..102339403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      102319603..102341520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368613.1XP_054224588.1  baculoviral IAP repeat-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q13489, Q16628, Q9HC27, Q9UP46