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    CTBP1 C-terminal binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 1487, updated on 5-May-2024

    Summary

    Official Symbol
    CTBP1provided by HGNC
    Official Full Name
    C-terminal binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2494
    See related
    Ensembl:ENSG00000159692 MIM:602618; AllianceGenome:HGNC:2494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BARS; HADDTS
    Summary
    This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    4p16.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1211445..1250355, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1210608..1249282, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1205233..1244143, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene hornerin-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1143546-1144046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1144047-1144547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21143 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1160925-1161208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1165551-1166266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1166267-1166984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1172226-1172726 Neighboring gene spondin 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1188097-1188808 Neighboring gene uncharacterized LOC100130872 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1190349-1191548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1193431-1193980 Neighboring gene uncharacterized LOC124900164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21149 Neighboring gene CTBP1 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1227715-1228270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1233764-1234264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21151 Neighboring gene CTBP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21152 Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15127 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1285078-1285260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1288606-1289569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1291085-1291798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1301806-1302703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1303601-1304498 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1311232-1311732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1317288-1318487 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:1319662-1320861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1332970-1333488

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of C-terminal binding protein 1 (CTBP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104684

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables NAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    C-terminal-binding protein 1
    Names
    brefeldin A-ribosylated substrate
    NP_001012632.1
    NP_001319.1
    NP_001364115.1
    NP_001364116.1
    NP_001364117.1
    NP_001364118.1
    NP_001364119.1
    NP_001364120.1
    NP_001364121.1
    NP_001364122.1
    XP_024309667.1
    XP_047305589.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052824.1 RefSeqGene

      Range
      6200..43885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012614.2NP_001012632.1  C-terminal-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001012632.1

      Status: REVIEWED

      Source sequence(s)
      AC092535, BC011655, BC053320, BM989059, BU553431
      Consensus CDS
      CCDS43203.1
      UniProtKB/TrEMBL
      Q4KMQ8
      Related
      ENSP00000372411.3, ENST00000382952.8
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. NM_001328.3NP_001319.1  C-terminal-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001319.1

      Status: REVIEWED

      Source sequence(s)
      AC092535, BC011655, BM989059, BU553431, U37408
      Consensus CDS
      CCDS3348.1
      UniProtKB/Swiss-Prot
      Q13363, Q4W5N3, Q7Z2Q5
      UniProtKB/TrEMBL
      Q4KMQ8, X5D8Y5
      Related
      ENSP00000290921.6, ENST00000290921.10
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. NM_001377186.1NP_001364115.1  C-terminal-binding protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC092535
      UniProtKB/TrEMBL
      Q4KMQ8
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    4. NM_001377187.1NP_001364116.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS93461.1
      UniProtKB/TrEMBL
      H0Y8U5, Q4KMQ8
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    5. NM_001377188.1NP_001364117.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS93461.1
      UniProtKB/TrEMBL
      H0Y8U5, Q4KMQ8
      Related
      ENSP00000515212.1, ENST00000703164.1
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    6. NM_001377189.1NP_001364118.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS93461.1
      UniProtKB/TrEMBL
      H0Y8U5, Q4KMQ8
      Related
      ENSP00000422148.2, ENST00000503594.6
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    7. NM_001377190.1NP_001364119.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS93461.1
      UniProtKB/TrEMBL
      H0Y8U5, Q4KMQ8
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    8. NM_001377191.1NP_001364120.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS43203.1
      UniProtKB/TrEMBL
      Q4KMQ8
      Related
      ENSP00000515211.1, ENST00000703163.1
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    9. NM_001377192.1NP_001364121.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS43203.1
      UniProtKB/TrEMBL
      Q4KMQ8
      Related
      ENSP00000515195.1, ENST00000703138.1
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    10. NM_001377193.1NP_001364122.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Consensus CDS
      CCDS43203.1
      UniProtKB/TrEMBL
      Q4KMQ8
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      1211445..1250355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449633.1XP_047305589.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      H0Y8U5
    2. XM_024453899.2XP_024309667.1  C-terminal-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4KMQ8
      Conserved Domains (1) summary
      cd05299
      Location:7272
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      1210608..1249282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)