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Ctbp1 C-terminal binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13016, updated on 11-Jun-2025
Official Symbol
Ctbp1provided by MGI
Official Full Name
C-terminal binding protein 1provided by MGI
Primary source
MGI:MGI:1201685
See related
Ensembl:ENSMUSG00000037373 AllianceGenome:MGI:1201685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and lncRNA binding activity. Involved in negative regulation of DNA-templated transcription; synaptic vesicle cycle; and white fat cell differentiation. Acts upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; chorionic plate; genitourinary system; limb; and lung. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 109.8), CNS E14 (RPKM 100.4) and 28 other tissues See more
Orthologs
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See Ctbp1 in Genome Data Viewer
Location:
5 B1; 5 17.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33405067..33432348, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33247723..33275004, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene spondin 2, extracellular matrix protein Neighboring gene predicted gene, 54327 Neighboring gene STARR-positive B cell enhancer ABC_E8049 Neighboring gene predicted gene, 51410 Neighboring gene predicted gene 20465

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in presynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C-terminal-binding protein 1
NP_001185788.1
NP_001185789.1
NP_001185790.1
NP_001297464.1
NP_001408504.1
NP_038530.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198859.1NP_001185788.1  C-terminal-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001185788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. It encodes a shorter isoform (1) compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001198860.1NP_001185789.1  C-terminal-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001185789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes a shorter isoform (2) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AJ010483, BE991938, CJ163412
    Consensus CDS
    CCDS80256.1
    UniProtKB/TrEMBL
    A0A0J9YU62
    Related
    ENSMUSP00000144024.2, ENSMUST00000202868.4
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001198861.1NP_001185790.1  C-terminal-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001185790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 3. It encodes a shorter isoform (4) with a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AK133816, BE991938, CJ163412
    UniProtKB/Swiss-Prot
    O88712
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. NM_001310535.1NP_001297464.1  C-terminal-binding protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 3. It encodes a shorter isoform (5) with a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AC115070
    Consensus CDS
    CCDS80255.1
    UniProtKB/Swiss-Prot
    O88712
    Related
    ENSMUSP00000144554.2, ENSMUST00000201575.4
    Conserved Domains (1) summary
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. NM_001421575.1NP_001408504.1  C-terminal-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115070
  6. NM_013502.3NP_038530.1  C-terminal-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_038530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AK133816, BE991938, CJ163412
    Consensus CDS
    CCDS19201.1
    UniProtKB/Swiss-Prot
    O88712, Q3TAT1, Q3TDL5, Q3TUM5, Q91WI6, Q91YX3, Q9QYG2
    Related
    ENSMUSP00000078682.7, ENSMUST00000079746.10
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    33405067..33432348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)