Ctbp1 C-terminal binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctbp1provided by MGI
Official Full Name: C-terminal binding protein 1provided by MGI
Primary source: MGI:MGI:1201685
See related: Ensembl:ENSMUSG00000037373 AllianceGenome:MGI:1201685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BARS; D4S115h; D5H4S115; D5H4S115E; CtBP3/BARS
Summary: Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and white fat cell differentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including central nervous system; genitourinary system; limb; lung; and neural retina. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 109.8), CNS E14 (RPKM 100.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33405067..33432467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33247723..33275004, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MCRIP1 interferes with interactions of CtBP with the lung-enriched transcriptional repressors, Foxp1 and Foxp2, thereby preventing the recruitment of the CtBP co-repressor complex to the SP-B and SP-C promoters and maintaining them in an active chromatin state. Homozygous deficiency of Mcrip1 in mice causes fatal respiratory distress due to abnormal transcriptional repression of surfactant proteins.
Title: MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing.
validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development
Title: Identification of reliable reference genes for qRT-PCR studies of the developing mouse mammary gland.
C-terminal binding protein 1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other forms of pulmonary hypertension
Title: Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.
CtBP1 protein is not essential for the formation of functional ribbon synapses in the retina.
Title: The ribbon-associated protein C-terminal-binding protein 1 is not essential for the structure and function of retinal ribbon synapses.
Study demonstrates differential regional and subcellular expression patterns for CtBP1 and CtBP2 in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.
Title: Differential spatial expression and subcellular localization of CtBP family members in rodent brain.
Data show that inhibition of the white adipocyte genes depends on PPARgamma and the expression of C/EBPalpha and the corepressors, carboxy-terminal binding proteins 1 and 2 (CtBP1/2).
Title: C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.
CtBP knockout increases Bax transcription, ablates mitochondrial morphology and reduces mitochondrial activities
Title: C-terminal binding protein maintains mitochondrial activities.
CtBP1 expressed in human CD4(+) T cells crucially contribute to Th1/Th2 differentiation via selective down-regulation of IL-4 synthesis.
Title: Suppressive role of C-terminal binding protein 1 in IL-4 synthesis in human T cells.
The regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs.
Title: Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis
Title: Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ctbp1 gene: The Ctbp1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 408 organisms have orthologs with human gene Ctbp1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of histone H4 acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of histone acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of histone deacetylation	ISO Inferred from Sequence Orthology more info
involved_in presynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-terminal-binding protein 1

NP_001185788.1

EC 1.1.1.-

NP_001185789.1

EC 1.1.1.-

NP_001185790.1

EC 1.1.1.-

NP_001297464.1

EC 1.1.1.-

NP_038530.1

EC 1.1.1.-

XP_030109965.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198859.1 → NP_001185788.1 C-terminal-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_001185788.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. It encodes a shorter isoform (1) compared to isoform 3.

Source sequence(s)

AJ010483, BE991938, CJ163412

UniProtKB/Swiss-Prot

O88712

UniProtKB/TrEMBL

A0A6P5PS80

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001198860.1 → NP_001185789.1 C-terminal-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001185789.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes a shorter isoform (2) with a distinct N-terminus compared to isoform 3.

Source sequence(s)

AJ010483, BE991938, CJ163412

Consensus CDS

CCDS80256.1

UniProtKB/Swiss-Prot

O88712

UniProtKB/TrEMBL

A0A0J9YU62, A0A6P5PJW4, A0A8C6HPD7

Related

ENSMUSP00000144024.2, ENSMUST00000202868.4

Conserved Domains (1) summary

cd05299
Location:17 → 335

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001198861.1 → NP_001185790.1 C-terminal-binding protein 1 isoform 4

See identical proteins and their annotated locations for NP_001185790.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at an alternate start codon, compared to variant 3. It encodes a shorter isoform (4) with a distinct N-terminus compared to isoform 3.

Source sequence(s)

AK133816, BE991938, CJ163412

UniProtKB/Swiss-Prot

O88712

UniProtKB/TrEMBL

A0A6P5PQM3

Conserved Domains (1) summary

cd05299
Location:17 → 335

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001310535.1 → NP_001297464.1 C-terminal-binding protein 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 3. It encodes a shorter isoform (5) with a shorter N-terminus compared to isoform 3.

Source sequence(s)

AC115070

Consensus CDS

CCDS80255.1

UniProtKB/Swiss-Prot

O88712

Related

ENSMUSP00000144554.2, ENSMUST00000201575.4

Conserved Domains (1) summary

cd05299
Location:7 → 272

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_013502.3 → NP_038530.1 C-terminal-binding protein 1 isoform 3

See identical proteins and their annotated locations for NP_038530.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AK133816, BE991938, CJ163412

Consensus CDS

CCDS19201.1

UniProtKB/Swiss-Prot

O88712, Q9QYG2

UniProtKB/TrEMBL

A0A6P5PPH0

Related

ENSMUSP00000078682.7, ENSMUST00000079746.10

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

33405067..33432467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254105.2 → XP_030109965.1 C-terminal-binding protein 1 isoform X1

Conserved Domains (1) summary

cd05299
Location:7 → 272

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor