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CTBP1 C-terminal binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1487, updated on 5-May-2024

Summary

Official Symbol
CTBP1provided by HGNC
Official Full Name
C-terminal binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2494
See related
Ensembl:ENSG00000159692 MIM:602618; AllianceGenome:HGNC:2494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BARS; HADDTS
Summary
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

Location:
4p16.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (1211445..1250355, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (1210608..1249282, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1205233..1244143, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene hornerin-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1143546-1144046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1144047-1144547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21143 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1160925-1161208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1165551-1166266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1166267-1166984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1172226-1172726 Neighboring gene spondin 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1188097-1188808 Neighboring gene uncharacterized LOC100130872 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1190349-1191548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1193431-1193980 Neighboring gene uncharacterized LOC124900164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21149 Neighboring gene CTBP1 antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1227715-1228270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1233764-1234264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21151 Neighboring gene CTBP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21152 Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15127 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:1285078-1285260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1288606-1289569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1291085-1291798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1301806-1302703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1303601-1304498 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:1311232-1311732 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:1317288-1318487 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:1319662-1320861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:1332970-1333488

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of C-terminal binding protein 1 (CTBP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC104684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynaptic active zone cytoplasmic component IEA
Inferred from Electronic Annotation
more info
 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-terminal-binding protein 1
Names
brefeldin A-ribosylated substrate
NP_001012632.1
NP_001319.1
NP_001364115.1
NP_001364116.1
NP_001364117.1
NP_001364118.1
NP_001364119.1
NP_001364120.1
NP_001364121.1
NP_001364122.1
XP_024309667.1
XP_047305589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052824.1 RefSeqGene

    Range
    6200..43885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012614.2NP_001012632.1  C-terminal-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001012632.1

    Status: REVIEWED

    Source sequence(s)
    AC092535, BC011655, BC053320, BM989059, BU553431
    Consensus CDS
    CCDS43203.1
    UniProtKB/TrEMBL
    Q4KMQ8
    Related
    ENSP00000372411.3, ENST00000382952.8
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001328.3NP_001319.1  C-terminal-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001319.1

    Status: REVIEWED

    Source sequence(s)
    AC092535, BC011655, BM989059, BU553431, U37408
    Consensus CDS
    CCDS3348.1
    UniProtKB/Swiss-Prot
    Q13363, Q4W5N3, Q7Z2Q5
    UniProtKB/TrEMBL
    Q4KMQ8, X5D8Y5
    Related
    ENSP00000290921.6, ENST00000290921.10
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001377186.1NP_001364115.1  C-terminal-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC092535
    UniProtKB/TrEMBL
    Q4KMQ8
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. NM_001377187.1NP_001364116.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS93461.1
    UniProtKB/TrEMBL
    H0Y8U5, Q4KMQ8
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. NM_001377188.1NP_001364117.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS93461.1
    UniProtKB/TrEMBL
    H0Y8U5, Q4KMQ8
    Related
    ENSP00000515212.1, ENST00000703164.1
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  6. NM_001377189.1NP_001364118.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS93461.1
    UniProtKB/TrEMBL
    H0Y8U5, Q4KMQ8
    Related
    ENSP00000422148.2, ENST00000503594.6
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  7. NM_001377190.1NP_001364119.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS93461.1
    UniProtKB/TrEMBL
    H0Y8U5, Q4KMQ8
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  8. NM_001377191.1NP_001364120.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS43203.1
    UniProtKB/TrEMBL
    Q4KMQ8
    Related
    ENSP00000515211.1, ENST00000703163.1
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  9. NM_001377192.1NP_001364121.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS43203.1
    UniProtKB/TrEMBL
    Q4KMQ8
    Related
    ENSP00000515195.1, ENST00000703138.1
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  10. NM_001377193.1NP_001364122.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS43203.1
    UniProtKB/TrEMBL
    Q4KMQ8
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    1211445..1250355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449633.1XP_047305589.1  C-terminal-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    H0Y8U5
  2. XM_024453899.2XP_024309667.1  C-terminal-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q4KMQ8
    Conserved Domains (1) summary
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    1210608..1249282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)