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CTBP1 C-terminal binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1487, updated on 24-Nov-2020

Summary

Official Symbol
CTBP1provided by HGNC
Official Full Name
C-terminal binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2494
See related
Ensembl:ENSG00000159692 MIM:602618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BARS; HADDTS
Summary
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See CTBP1 in Genome Data Viewer
Location:
4p16.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (1211444..1250355, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1205228..1242908, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374344 Neighboring gene transmembrane p24 trafficking protein 11, pseudogene Neighboring gene spondin 2 Neighboring gene uncharacterized LOC100130872 Neighboring gene uncharacterized LOC101928548 Neighboring gene CTBP1 antisense RNA Neighboring gene CTBP1 divergent transcript Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of C-terminal binding protein 1 (CTBP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104684

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of histone H4 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral genome replication TAS
Traceable Author Statement
more info
PubMed 
white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-terminal-binding protein 1
Names
brefeldin A-ribosylated substrate

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052824.1 RefSeqGene

    Range
    6200..43885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012614.2NP_001012632.1  C-terminal-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001012632.1

    Status: REVIEWED

    Source sequence(s)
    AC092535, BC011655, BC053320, BM989059, BU553431
    Consensus CDS
    CCDS43203.1
    UniProtKB/Swiss-Prot
    Q13363
    Related
    ENSP00000372411.3, ENST00000382952.7
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001328.3NP_001319.1  C-terminal-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001319.1

    Status: REVIEWED

    Source sequence(s)
    AC092535, BC011655, BM989059, BU553431, U37408
    Consensus CDS
    CCDS3348.1
    UniProtKB/Swiss-Prot
    Q13363
    UniProtKB/TrEMBL
    X5D8Y5
    Related
    ENSP00000290921.6, ENST00000290921.10
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001377186.1NP_001364115.1  C-terminal-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:28346
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. NM_001377187.1NP_001364116.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. NM_001377188.1NP_001364117.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  6. NM_001377189.1NP_001364118.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  7. NM_001377190.1NP_001364119.1  C-terminal-binding protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  8. NM_001377191.1NP_001364120.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  9. NM_001377192.1NP_001364121.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  10. NM_001377193.1NP_001364122.1  C-terminal-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC092535
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    1211444..1250355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007764.1XP_016863253.1  C-terminal-binding protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q13363
    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. XM_005272263.5XP_005272320.1  C-terminal-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005272320.1

    Conserved Domains (1) summary
    cd05299
    Location:17335
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. XM_024453899.1XP_024309667.1  C-terminal-binding protein 1 isoform X4

    Conserved Domains (1) summary
    cd05299
    Location:7272
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
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