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    UBE2E3 ubiquitin conjugating enzyme E2 E3 [ Homo sapiens (human) ]

    Gene ID: 10477, updated on 7-Apr-2024

    Summary

    Official Symbol
    UBE2E3provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 E3provided by HGNC
    Primary source
    HGNC:HGNC:12479
    See related
    Ensembl:ENSG00000170035 MIM:604151; AllianceGenome:HGNC:12479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBCH9; UbcM2
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UBE2E3 in Genome Data Viewer
    Location:
    2q31.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (180980360..181063425)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (181470000..181553425)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (181845087..181928152)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF complex antagonist associated with prostate cancer 1 Neighboring gene ferritin heavy chain 1 pseudogene 20 Neighboring gene ribosomal protein L27a pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16822 Neighboring gene UBE2E3 divergent transcript Neighboring gene uncharacterized LOC107985831 Neighboring gene NANOG hESC enhancer GRCh37_chr2:181971702-181972203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16823 Neighboring gene long intergenic non-protein coding RNA 1934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16824 Neighboring gene microRNA 4437

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study on obesity and obesity-related traits.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin-conjugating enzyme E2E 3 (UBE2E3) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 E3
    Names
    E2 ubiquitin-conjugating enzyme E3
    ubiquitin carrier protein E3
    ubiquitin conjugating enzyme E2E 3
    ubiquitin-conjugating enzyme E2-23 kDa
    ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
    ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)
    ubiquitin-protein ligase E3
    NP_001265483.1
    NP_001265484.1
    NP_006348.1
    NP_872619.1
    XP_005246301.1
    XP_016858656.1
    XP_054196155.1
    XP_054196156.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278554.2NP_001265483.1  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_001265483.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC104076, AK314145, BU608985, DA568152
      Consensus CDS
      CCDS2282.1
      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4
      UniProtKB/TrEMBL
      A0A1B0GX65
      Related
      ENSP00000473623.1, ENST00000602710.5
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001278555.2NP_001265484.1  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_001265484.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC104076, BC092407, BI257596, BQ932163, BU608985
      Consensus CDS
      CCDS2282.1
      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4
      UniProtKB/TrEMBL
      A0A1B0GX65
      Related
      ENSP00000376215.2, ENST00000392415.6
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_006357.4NP_006348.1  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_006348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      BC092407, BU608985, DB458228
      Consensus CDS
      CCDS2282.1
      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4
      UniProtKB/TrEMBL
      A0A1B0GX65
      Related
      ENSP00000386788.3, ENST00000410062.9
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme
    4. NM_182678.3NP_872619.1  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_872619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC104076, BC092407, BQ932163, BU608985
      Consensus CDS
      CCDS2282.1
      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4
      UniProtKB/TrEMBL
      A0A1B0GX65
      Related
      ENSP00000473639.1, ENST00000602959.5
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      180980360..181063425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003167.3XP_016858656.1  ubiquitin-conjugating enzyme E2 E3 isoform X2

    2. XM_005246244.3XP_005246301.1  ubiquitin-conjugating enzyme E2 E3 isoform X1

      See identical proteins and their annotated locations for XP_005246301.1

      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4
      UniProtKB/TrEMBL
      A0A1B0GX65
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      181470000..181553425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340181.1XP_054196156.1  ubiquitin-conjugating enzyme E2 E3 isoform X2

    2. XM_054340180.1XP_054196155.1  ubiquitin-conjugating enzyme E2 E3 isoform X1

      UniProtKB/Swiss-Prot
      B2RAD6, D3DPG3, Q5U0R7, Q7Z4W4, Q969T4