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Ube2e3 ubiquitin-conjugating enzyme E2E 3 [ Mus musculus (house mouse) ]

Gene ID: 22193, updated on 17-Aug-2024

Summary

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Official Symbol
Ube2e3provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2E 3provided by MGI
Primary source
MGI:MGI:107412
See related
Ensembl:ENSMUSG00000027011 AllianceGenome:MGI:107412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubce4; ubcM2
Summary
Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Predicted to act upstream of or within regulation of growth. Located in nucleus. Orthologous to human UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 33.4), CNS E14 (RPKM 32.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 47.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (78698696..78759132)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (78868236..78928786)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39865 Neighboring gene predicted gene 17014 Neighboring gene STARR-positive B cell enhancer ABC_E4470 Neighboring gene STARR-positive B cell enhancer ABC_E10119 Neighboring gene STARR-positive B cell enhancer ABC_E1246 Neighboring gene predicted gene, 37004 Neighboring gene STARR-positive B cell enhancer ABC_E10120 Neighboring gene STARR-positive B cell enhancer ABC_E4471 Neighboring gene STARR-positive B cell enhancer ABC_E5937 Neighboring gene predicted gene, 35748

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Bedard N, et al. Mol Cell Biol, 2005 Aug. PMID 16024774, Free PMC Article
  2. Isolation of growth suppressors from a cDNA expression library. Pestov DG, et al. Oncogene, 1998 Dec 17. PMID 9872334
  3. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Harbers K, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901595, Free PMC Article
  4. Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel. Debonneville C, et al. Mol Cell Biol, 2004 Mar. PMID 14993279, Free PMC Article
  5. RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination. Kong Q, et al. Biochem Biophys Res Commun, 2010 Mar 19. PMID 20170641

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBC4-testis isoform plays a role in early maturation of the testis
    Title: Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 E3
Names
E2 ubiquitin-conjugating enzyme E3
ubiquitin carrier protein E3
ubiquitin-conjugating enzyme 4
ubiquitin-conjugating enzyme E2-23 kDa
ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog
ubiquitin-protein ligase E3
NP_001343324.1
NP_001408107.1
NP_001408108.1
NP_001408109.1
NP_001408110.1
NP_001408111.1
NP_001408112.1
NP_001408113.1
NP_001408114.1
NP_001408115.1
NP_033480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356395.2 → NP_001343324.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-9 all encode the same isoform (a).
    Source sequence(s)
    AL772181, AL928604
    Consensus CDS
    CCDS16167.1
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63
    Related
    ENSMUSP00000113463.2, ENSMUST00000121433.2
    Conserved Domains (1) summary
    pfam00179
    Location:65 → 202
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001421178.1 → NP_001408107.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63

  3. NM_001421179.1 → NP_001408108.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63

  4. NM_001421180.1 → NP_001408109.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63

  5. NM_001421181.1 → NP_001408110.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63

  6. NM_001421182.1 → NP_001408111.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63

  7. NM_001421183.1 → NP_001408112.1  ubiquitin-conjugating enzyme E2 E3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604

  8. NM_001421184.1 → NP_001408113.1  ubiquitin-conjugating enzyme E2 E3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604

  9. NM_001421185.1 → NP_001408114.1  ubiquitin-conjugating enzyme E2 E3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604

  10. NM_001421186.1 → NP_001408115.1  ubiquitin-conjugating enzyme E2 E3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928604

  11. NM_009454.3 → NP_033480.1  ubiquitin-conjugating enzyme E2 E3 isoform a

    See identical proteins and their annotated locations for NP_033480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-9 all encode the same isoform (a).
    Source sequence(s)
    AL772181, AL928604
    Consensus CDS
    CCDS16167.1
    UniProtKB/Swiss-Prot
    O09180, P52483, Q3TI00, Q91X63
    Related
    ENSMUSP00000028398.8, ENSMUST00000028398.14
    Conserved Domains (1) summary
    pfam00179
    Location:65 → 202
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. NR_151457.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL772181, AL928604

  2. NR_151458.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL772181, AL928604

  3. NR_185265.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604

  4. NR_185266.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772181, AL928604

  5. NR_185267.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772181

  6. NR_185268.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772181

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    78698696..78759132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52483.2 GenPept UniProtKB/Swiss-Prot:P52483

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