Ube2e3 ubiquitin-conjugating enzyme E2E 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2e3provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2E 3provided by MGI
Primary source: MGI:MGI:107412
See related: Ensembl:ENSMUSG00000027011 AllianceGenome:MGI:107412
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubce4; ubcM2
Summary: Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Predicted to act upstream of or within regulation of growth. Located in nucleus. Orthologous to human UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 33.4), CNS E14 (RPKM 32.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 C3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (78698577..78759130)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (78868236..78928786)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBC4-testis isoform plays a role in early maturation of the testis
Title: Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ube2e3 gene: The Ube2e3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 385 organisms have orthologs with human gene Ube2e3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 E3

Names: E2 ubiquitin-conjugating enzyme E3; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme 4; ubiquitin-conjugating enzyme E2-23 kDa; ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog; ubiquitin-protein ligase E3

NP_001343324.1

EC 2.3.2.23

NP_033480.1

EC 2.3.2.23

XP_006499225.1

EC 2.3.2.23

XP_006499226.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356395.1 → NP_001343324.1 ubiquitin-conjugating enzyme E2 E3

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variant 1, is a protein-coding variant. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL772181, AL928604

Consensus CDS

CCDS16167.1

UniProtKB/Swiss-Prot

Q91X63

UniProtKB/TrEMBL

A0A8C6GNN5

Related

ENSMUSP00000113463.2, ENSMUST00000121433.2

Conserved Domains (1) summary

pfam00179
Location:65 → 202

UQ_con; Ubiquitin-conjugating enzyme
NM_009454.2 → NP_033480.1 ubiquitin-conjugating enzyme E2 E3

See identical proteins and their annotated locations for NP_033480.1

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variant 2, is a protein-coding variant. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BC011477

Consensus CDS

CCDS16167.1

UniProtKB/Swiss-Prot

P52483, Q91X63

UniProtKB/TrEMBL

A0A8C6GNN5

Related

ENSMUSP00000028398.8, ENSMUST00000028398.14

Conserved Domains (1) summary

pfam00179
Location:65 → 202

UQ_con; Ubiquitin-conjugating enzyme

RNA

NR_151457.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL772181, AL928604
NR_151458.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL772181, AL928604