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UBE2E3 ubiquitin conjugating enzyme E2 E3 [ Homo sapiens (human) ]

Gene ID: 10477, updated on 9-Sep-2018

Summary

Official Symbol
UBE2E3provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 E3provided by HGNC
Primary source
HGNC:HGNC:12479
See related
Ensembl:ENSG00000170035 MIM:604151; Vega:OTTHUMG00000132585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBCH9; UbcM2
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See UBE2E3 in Genome Data Viewer
Location:
2q31.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (180980385..181063427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (181845112..181928154)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27a pseudogene 3 Neighboring gene uncharacterized LOC105373772 Neighboring gene uncharacterized LOC107985831 Neighboring gene long intergenic non-protein coding RNA 1934 Neighboring gene microRNA 4437

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2E 3 (UBE2E3) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein ubiquitination, organism-specific biosystem (from REACTOME)
    Protein ubiquitination, organism-specific biosystemUbiquitin is a small, 76 amino acid residue protein that is conjugated by E3 ubiquitin ligases to other proteins in order to regulate their function or degradation (enzymatic cascade reviewed in Neut...
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes, organism-specific biosystem (from REACTOME)
    Synthesis of active ubiquitin: roles of E1 and E2 enzymes, organism-specific biosystemUbiquitin monomers are processed from larger precursors and then activated by formation of a thiol ester bond between ubiquitin and a cysteine residue of an E1 activating enzyme (UBA1 or UBA6, Jin et...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • protein ubiquitylation, organism-specific biosystem (from BIOCYC)
    protein ubiquitylation, organism-specific biosystem
    protein ubiquitylation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 E3
Names
E2 ubiquitin-conjugating enzyme E3
ubiquitin carrier protein E3
ubiquitin conjugating enzyme E2E 3
ubiquitin-conjugating enzyme E2-23 kDa
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)
ubiquitin-protein ligase E3
NP_001265483.1
NP_001265484.1
NP_006348.1
NP_872619.1
XP_005246301.1
XP_011508794.1
XP_016858655.1
XP_016858656.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278554.1NP_001265483.1  ubiquitin-conjugating enzyme E2 E3

    See identical proteins and their annotated locations for NP_001265483.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK314145, BU608985, DA568152
    Consensus CDS
    CCDS2282.1
    UniProtKB/Swiss-Prot
    Q969T4
    Related
    ENSP00000473623.1, OTTHUMP00000205276, ENST00000602710.5, OTTHUMT00000334324
    Conserved Domains (1) summary
    pfam00179
    Location:65202
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_001278555.1NP_001265484.1  ubiquitin-conjugating enzyme E2 E3

    See identical proteins and their annotated locations for NP_001265484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC092407, BI257596, BQ932163, BU608985
    Consensus CDS
    CCDS2282.1
    UniProtKB/Swiss-Prot
    Q969T4
    Related
    ENSP00000376215.2, ENST00000392415.6
    Conserved Domains (1) summary
    pfam00179
    Location:65202
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_006357.3NP_006348.1  ubiquitin-conjugating enzyme E2 E3

    See identical proteins and their annotated locations for NP_006348.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC092407, BU608985, CN369618, DB458228
    Consensus CDS
    CCDS2282.1
    UniProtKB/Swiss-Prot
    Q969T4
    Related
    ENSP00000386788.3, OTTHUMP00000163407, ENST00000410062.8, OTTHUMT00000255795
    Conserved Domains (1) summary
    pfam00179
    Location:65202
    UQ_con; Ubiquitin-conjugating enzyme
  4. NM_182678.2NP_872619.1  ubiquitin-conjugating enzyme E2 E3

    See identical proteins and their annotated locations for NP_872619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC092407, BQ932163, BU608985
    Consensus CDS
    CCDS2282.1
    UniProtKB/Swiss-Prot
    Q969T4
    Related
    ENSP00000473639.1, OTTHUMP00000205277, ENST00000602959.5, OTTHUMT00000334325
    Conserved Domains (1) summary
    pfam00179
    Location:65202
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    180980385..181063427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003167.2XP_016858656.1  ubiquitin-conjugating enzyme E2 E3 isoform X4

  2. XM_011510492.3XP_011508794.1  ubiquitin-conjugating enzyme E2 E3 isoform X3

    UniProtKB/TrEMBL
    R4GNG6
    Related
    ENSP00000473642.1, OTTHUMP00000205300, ENST00000602632.1
  3. XM_017003166.2XP_016858655.1  ubiquitin-conjugating enzyme E2 E3 isoform X2

  4. XM_005246244.2XP_005246301.1  ubiquitin-conjugating enzyme E2 E3 isoform X1

    See identical proteins and their annotated locations for XP_005246301.1

    UniProtKB/Swiss-Prot
    Q969T4
    Conserved Domains (1) summary
    pfam00179
    Location:65202
    UQ_con; Ubiquitin-conjugating enzyme
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