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    ZNF773 zinc finger protein 773 [ Homo sapiens (human) ]

    Gene ID: 374928, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ZNF773provided by HGNC
    Official Full Name
    zinc finger protein 773provided by HGNC
    Primary source
    HGNC:HGNC:30487
    See related
    Ensembl:ENSG00000152439 AllianceGenome:HGNC:30487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF419B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.6), ovary (RPKM 2.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57499938..57518437)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60596886..60615371)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58011306..58029805)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:57988249-57989448 Neighboring gene zinc finger protein 772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57998906-57999406 Neighboring gene zinc finger protein 419 Neighboring gene zinc finger protein 549 Neighboring gene zinc finger protein 550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58070497-58071361 Neighboring gene uncharacterized LOC124904781 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:58071339-58072538

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4728, FLJ00301

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 773
    Names
    zinc finger protein 419B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304334.2 → NP_001291263.1  zinc finger protein 773 isoform b

      See identical proteins and their annotated locations for NP_001291263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC003005, AK057209
      Consensus CDS
      CCDS77368.1
      UniProtKB/Swiss-Prot
      Q6PK81
      Related
      ENSP00000469416.1, ENST00000598770.5
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:208 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:192 → 212
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:372 → 396
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001304335.3 → NP_001291264.1  zinc finger protein 773 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is shorter, and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC003005, AC003682, DA650616
      UniProtKB/TrEMBL
      M0QX16
      Related
      ENSP00000468846.1, ENST00000599847.5
      Conserved Domains (2) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      pfam01352
      Location:14 → 53
      KRAB; KRAB box

    3. NM_001304336.2 → NP_001291265.1  zinc finger protein 773 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, and uses two alternate splice site in the coding region, one of which results in a frameshift compared to variant 1. The encoded isoform (d) is shorter, and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC003005
      UniProtKB/TrEMBL
      E5RIA3
      Conserved Domains (1) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box

    4. NM_001304337.3 → NP_001291266.1  zinc finger protein 773 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) is shorter, and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC003005, AC003682
      Consensus CDS
      CCDS77369.1
      UniProtKB/TrEMBL
      M0QX16, M0QYZ8
      Related
      ENSP00000470189.1, ENST00000593916.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box

    5. NM_198542.3 → NP_940944.1  zinc finger protein 773 isoform a

      See identical proteins and their annotated locations for NP_940944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC003005, BC005167
      Consensus CDS
      CCDS33134.1
      UniProtKB/Swiss-Prot
      Q6PK81, Q96DL8
      Related
      ENSP00000282292.3, ENST00000282292.9
      Conserved Domains (5) summary
      smart00349
      Location:15 → 75
      KRAB; krueppel associated box
      COG5048
      Location:209 → 438
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 54
      KRAB; KRAB box
      pfam13465
      Location:373 → 397
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_130705.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003005, BX365407, BX382674
      Related
      ENST00000597061.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57499938..57518437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007066799.1 RNA Sequence

    2. XR_007066800.1 RNA Sequence

    3. XR_007066801.1 RNA Sequence

    4. XR_007066802.1 RNA Sequence

    5. XR_007066803.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60596886..60615371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008485141.1 RNA Sequence

    2. XR_008485142.1 RNA Sequence

    3. XR_008485143.1 RNA Sequence

    4. XR_008485144.1 RNA Sequence

    5. XR_008485145.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PK81.1 GenPept UniProtKB/Swiss-Prot:Q6PK81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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