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    H3f4 H3.4 histone, cluster member [ Mus musculus (house mouse) ]

    Gene ID: 382523, updated on 17-Aug-2024

    Summary

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    Official Symbol
    H3f4provided by MGI
    Official Full Name
    H3.4 histone, cluster memberprovided by MGI
    Primary source
    MGI:MGI:3651326
    See related
    Ensembl:ENSMUSG00000080152 AllianceGenome:MGI:3651326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H3t; H304; H3mmT; Gm12260
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Dec 2015]
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 36.39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58852537..58853099)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58961711..58962273)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2B clustered histone 26 Neighboring gene H2A clustered histone 25 Neighboring gene tripartite motif-containing 17 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene tripartite motif-containing 11 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. Ueda J, et al. Cell Rep, 2017 Jan 17. PMID 28099840
    2. Tissue-specific expression of histone H3 variants diversified after species separation. Maehara K, et al. Epigenetics Chromatin, 2015. PMID 26388943, Free PMC Article
    3. Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis. Govin J, et al. J Cell Biol, 2007 Jan 29. PMID 17261847, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    uncharacterized protein LOC382523
    Names
    H3.4 histone
    histone cluster 1, H3 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318003.2 → NP_001304932.1  uncharacterized protein LOC382523

      Status: REVIEWED

      Source sequence(s)
      AL662809
      UniProtKB/TrEMBL
      A0A8I4SYN6, A1L0V4
      Related
      ENSMUSP00001091671.1, ENSMUST00000122447.3
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58852537..58853099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_008452.1: Suppressed sequence

      Description
      NG_008452.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.