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H3-4 H3.4 histone, cluster member [ Homo sapiens (human) ]

Gene ID: 8290, updated on 5-Aug-2022


Official Symbol
H3-4provided by HGNC
Official Full Name
H3.4 histone, cluster memberprovided by HGNC
Primary source
See related
Ensembl:ENSG00000168148 MIM:602820; AllianceGenome:HGNC:4778
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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Genomic context

See H3-4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228424845..228425360, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227613357..227613872, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228612546..228613061, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 11 Neighboring gene microRNA 6742 Neighboring gene uncharacterized LOC124904537 Neighboring gene tripartite motif containing 17 Neighboring gene uncharacterized LOC124904538 Neighboring gene ribosomal protein L23a pseudogene 15

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev co-localizes with histone H3 in the nucleoplasmic compartment of cells PubMed
Tat tat Phosphorylation of serine 10 in histone H3 at the HIV promoter is increased in the presence of HIV-1 Tat PubMed
tat Purified recombinant Tat and Tat-derived synthetic peptides derived from the p300- and PCAF-binding sites in Tat inhibit histone H3/H4 acetylation in vitro PubMed
tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC126886, MGC126888

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
involved_in nucleosome assembly IMP
Inferred from Mutant Phenotype
more info

General protein information

Preferred Names
histone H3.1t
H3 clustered histone 16
H3 histone family, member T
H3.4 histone
histone 3, H3
histone H3.4
histone cluster 3 H3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003493.3NP_003484.1  histone H3.1t

    See identical proteins and their annotated locations for NP_003484.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    Q16695, Q6FGU4
    ENSP00000355657.2, ENST00000366696.2
    Conserved Domains (1) summary
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    228424845..228425360 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES


  1. NW_018654708.1 Reference GRCh38.p14 PATCHES

    16044..16559 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    227613357..227613872 complement
    GenBank, FASTA, Sequence Viewer (Graphics)