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    Zfp277 zinc finger protein 277 [ Mus musculus (house mouse) ]

    Gene ID: 246196, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Zfp277provided by MGI
    Official Full Name
    zinc finger protein 277provided by MGI
    Primary source
    MGI:MGI:1890393
    See related
    Ensembl:ENSMUSG00000055917 AllianceGenome:MGI:1890393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIRF4; Znf277; 2410017E24Rik
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF277 (zinc finger protein 277). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.2), CNS E18 (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 B1; 12 18.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40365045..40495789, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40315046..40445790, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40949998-40950107 Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40983751-40984051 Neighboring gene STARR-seq mESC enhancer starr_31955 Neighboring gene predicted gene 7008 Neighboring gene predicted gene, 40403 Neighboring gene STARR-seq mESC enhancer starr_31956 Neighboring gene STARR-seq mESC enhancer starr_31957 Neighboring gene STARR-seq mESC enhancer starr_31958 Neighboring gene STARR-positive B cell enhancer mm9_chr12:41172293-41172594 Neighboring gene predicted gene, 40406 Neighboring gene STARR-seq mESC enhancer starr_31959 Neighboring gene STARR-seq mESC enhancer starr_31960 Neighboring gene dedicator of cytokinesis 4 Neighboring gene STARR-seq mESC enhancer starr_31961 Neighboring gene STARR-seq mESC enhancer starr_31962 Neighboring gene STARR-seq mESC enhancer starr_31963 Neighboring gene STARR-seq mESC enhancer starr_31965 Neighboring gene STARR-seq mESC enhancer starr_31966 Neighboring gene predicted gene, 19441

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Liang H, et al. Genomics, 2000 Jun 1. PMID 10860669
    2. Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. Xie G, et al. JCI Insight, 2022 Feb 22. PMID 35015732, Free PMC Article
    3. Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Cheng K, et al. Mol Cancer, 2014 Apr 3. PMID 24694019, Free PMC Article
    4. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. Negishi M, et al. PLoS One, 2010 Aug 24. PMID 20808772, Free PMC Article
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results identify a novel candidate mouse gene, Zfp277, whose expression pattern is compatible with a role in mediating divergent effects of Chrm3 and Chrm1 gene ablation on murine intestinal neoplasia.
      Title: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia.
    2. Zfp277 in the transcriptional regulation of the Ink4a/Arf locus and the recruitment of PRC1 to the Ink4a/Arf locus
      Title: A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 277

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172575.3 → NP_766163.2  zinc finger protein 277 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123855, AK077401, BY206876
      Consensus CDS
      CCDS36435.1
      UniProtKB/Swiss-Prot
      E9Q6D6, Q3U0V6, Q3UM86, Q80UK2, Q8BVL5, Q8BVX7
      Related
      ENSMUSP00000064226.9, ENSMUST00000069692.10
      Conserved Domains (2) summary
      sd00020
      Location:353 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:302 → 389
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    2. NM_178845.3 → NP_849173.2  zinc finger protein 277 isoform 2

      See identical proteins and their annotated locations for NP_849173.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC123855, AK075945, BY206876
      Consensus CDS
      CCDS25894.1
      UniProtKB/TrEMBL
      Q3U0V6, Q8BVX7
      Related
      ENSMUSP00000068032.8, ENSMUST00000069637.15
      Conserved Domains (2) summary
      sd00020
      Location:227 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:176 → 263
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40365045..40495789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6D6.1 GenPept UniProtKB/Swiss-Prot:E9Q6D6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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