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    EIF3G eukaryotic translation initiation factor 3 subunit G [ Homo sapiens (human) ]

    Gene ID: 8666, updated on 7-Apr-2024

    Summary

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    Official Symbol
    EIF3Gprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Gprovided by HGNC
    Primary source
    HGNC:HGNC:3274
    See related
    Ensembl:ENSG00000130811 MIM:603913; AllianceGenome:HGNC:3274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
    Summary
    This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    19p13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10115014..10119899, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10241223..10246106, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10225690..10230575, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPAN-P2RY11 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10218607-10219250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10220162-10220743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13939 Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10229321-10230077 Neighboring gene peter pan homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10230078-10230833 Neighboring gene purinergic receptor P2Y11 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10243570-10243866 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10246117-10247316 Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10294611-10295111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13940 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10310838-10311338 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition. Simonetti A, et al. Mol Cell, 2016 Jul 21. PMID 27373335
    2. Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells. Zheng Q, et al. Mol Med Rep, 2016 Apr. PMID 26935993, Free PMC Article
    3. EIF3G is associated with narcolepsy across ethnicities. Holm A, et al. Eur J Hum Genet, 2015 Nov. PMID 25669430, Free PMC Article
    4. Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g). Kim JT, et al. FEBS Lett, 2013 Nov 15. PMID 24080033
    5. Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g. Choe J, et al. J Biol Chem, 2012 May 25. PMID 22493286, Free PMC Article

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.
      Title: An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.
    2. In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
      Title: In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
    3. The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression.
      Title: EIF3G is associated with narcolepsy across ethnicities.
    4. Important roles for eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
      Title: Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).
    5. down-regulation of eIF3g inhibits the efficiency of nonsense-mediated mRNA decay, which is tightly coupled to CT but not to ET
      Title: Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.
    6. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
      Title: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
    7. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses.
      Title: A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.
    8. AIF overexpression specifically resulted in the activation of caspase-7, thereby amplifying the inhibition of protein
      Title: Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit G (EIF3G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational termination-reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit G
    Names
    eukaryotic translation initiation factor 3 RNA-binding subunit
    eukaryotic translation initiation factor 3 subunit p42
    eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051197.1 RefSeqGene

      Range
      5026..9911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003755.5 → NP_003746.2  eukaryotic translation initiation factor 3 subunit G

      See identical proteins and their annotated locations for NP_003746.2

      Status: REVIEWED

      Source sequence(s)
      AA588881, BC000733
      Consensus CDS
      CCDS12227.1
      UniProtKB/Swiss-Prot
      O14801, O75821, Q969U5
      UniProtKB/TrEMBL
      A8K5K5, Q6IAM0
      Related
      ENSP00000253108.3, ENST00000253108.9
      Conserved Domains (2) summary
      cd12933
      Location:62 → 173
      eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
      cd12408
      Location:240 → 315
      RRM_eIF3G_like; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10115014..10119899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10241223..10246106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75821.2 GenPept UniProtKB/Swiss-Prot:O75821

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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