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    TASOR2 transcription activation suppressor family member 2 [ Homo sapiens (human) ]

    Gene ID: 54906, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TASOR2provided by HGNC
    Official Full Name
    transcription activation suppressor family member 2provided by HGNC
    Primary source
    HGNC:HGNC:23484
    See related
    Ensembl:ENSG00000108021 AllianceGenome:HGNC:23484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM208B; C10orf18; bA318E3.2
    Summary
    Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 5.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p15.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (5684838..5763740)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (5688634..5767529)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5726801..5805703)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984199 Neighboring gene RNA, 7SL, cytoplasmic 445, pseudogene Neighboring gene ankyrin repeat and SOCS box containing 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5702971-5703707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2085 Neighboring gene Sharpr-MPRA regulatory region 2494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:5793844-5794458 Neighboring gene MPRA-validated peak855 silencer Neighboring gene GDP dissociation inhibitor 2 Neighboring gene nuclear receptor binding factor 2 pseudogene 5 Neighboring gene uncharacterized LOC124902367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:5854819-5855411

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies two susceptibility loci for osteosarcoma. Savage SA, et al. Nat Genet, 2013 Jul. PMID 23727862, Free PMC Article
    2. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. Katzenellenbogen RA, et al. J Virol, 2007 Apr. PMID 17267499, Free PMC Article
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug 22. PMID 21697133
    4. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. Daakour S, et al. BMC Cancer, 2016 May 26. PMID 27229929, Free PMC Article
    5. Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology. Su Y, et al. BMC Genomics, 2023 Mar 24. PMID 36964488, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies two susceptibility loci for osteosarcoma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20360, DKFZp781E1986

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein TASOR 2
    Names
    family with sequence similarity 208 member B
    protein FAM208B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021250.2 RefSeqGene

      Range
      5002..83904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321783.2 → NP_001308712.2  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000512130.1, ENST00000695737.1
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552 → 701
      DUF3715; Protein of unknown function (DUF3715)

    2. NM_001321784.2 → NP_001308713.2  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000512207.1, ENST00000695834.1
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552 → 701
      DUF3715; Protein of unknown function (DUF3715)

    3. NM_001321785.2 → NP_001308714.2  protein TASOR 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS91209.1
      UniProtKB/TrEMBL
      A0A8Q3SI68, A0A8Q3SI84
      Related
      ENSP00000512206.1, ENST00000695833.1
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:471 → 620
      DUF3715; Protein of unknown function (DUF3715)

    4. NM_001387328.1 → NP_001374257.1  protein TASOR 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS91208.1
      UniProtKB/TrEMBL
      A0A2R8YH03, A0A8V8TMN1
      Related
      ENSP00000496466.1, ENST00000645567.1
      Conserved Domains (2) summary
      pfam12480
      Location:309 → 382
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:767 → 916
      DUF3715; Protein of unknown function (DUF3715)

    5. NM_017782.5 → NP_060252.5  protein TASOR 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365356, AL596094
      Consensus CDS
      CCDS41485.1
      UniProtKB/Swiss-Prot
      Q2YD91, Q5VWN5, Q5VWN6, Q6ZRQ8, Q8IVG4, Q9BUZ7, Q9H5J9, Q9H7A4, Q9H996, Q9NXA1
      UniProtKB/TrEMBL
      A0A8Q3SI68
      Related
      ENSP00000328426.5, ENST00000328090.9
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:552 → 701
      DUF3715; Protein of unknown function (DUF3715)

    RNA

    1. NR_135800.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365356, R42352

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      5684838..5763740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      5688634..5767529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VWN6.1 GenPept UniProtKB/Swiss-Prot:Q5VWN6

    Gene LinkOut

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