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    CTNNA1 catenin alpha 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 474698, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CTNNA1provided by VGNC
    Official Full Name
    catenin alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:51706
    See related
    Ensembl:ENSCAFG00845022250
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (27129159..27315090)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (25040958..25226366)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (26323192..26509271)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (25836828..26022382)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (25658855..25844720)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD63 Neighboring gene heat shock protein family A (Hsp70) member 9 Neighboring gene uncharacterized LOC102156696 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene uncharacterized LOC119873903 Neighboring gene uncharacterized LOC111098037 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration. Matsuzawa K, et al. Cell Rep, 2018 Jun 19. PMID 29924989
    2. α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction. Barry AK, et al. J Cell Sci, 2014 Apr 15. PMID 24522187, Free PMC Article
    3. ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions. Maiers JL, et al. J Cell Sci, 2013 Sep 1. PMID 23813953, Free PMC Article
    4. Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape. Gavilan MP, et al. PLoS Biol, 2015 Mar. PMID 25764135, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-catenin controls the establishment of anisotropic force distribution at cell junctions to enable cooperative movement of the epithelial cell sheet.
      Title: α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.
    2. Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape.
      Title: Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape.
    3. Alpha-catenin alters traction force generation but it is not the sole regulator of cell contractility on compliant CDH1 mediated adhesions.
      Title: α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.
    4. our study identifies alpha-catenin binding to ZO-1 as a new mechanism for coupling the assembly of the epithelial barrier to cell-to-cell adhesion.
      Title: ZO-1 recruitment to α-catenin--a novel mechanism for coupling the assembly of tight junctions to adherens junctions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catenin alpha-1
    Names
    catenin (cadherin-associated protein), alpha 1, 102kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      27129159..27315090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038681674.1 → XP_038537602.1  catenin alpha-1

      UniProtKB/TrEMBL
      A0A8C0SQK1, A0A8C0STJ7, A0A8I3PJB0, A0A8I3PPA7
      Related
      ENSCAFP00845031068.1, ENSCAFT00845039659.1
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      25836828..26022382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038490232.1 → XP_038346160.1  catenin alpha-1

      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      25658855..25844720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038616181.1 → XP_038472109.1  catenin alpha-1

      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      26323192..26509271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038552316.1 → XP_038408244.1  catenin alpha-1

      UniProtKB/TrEMBL
      A0A8C0SQK1, A0A8C0STJ7, A0A8I3PJB0, A0A8I3PPA7
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25040958..25226366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003431634.6 → XP_003431682.1  catenin alpha-1

      UniProtKB/TrEMBL
      A0A8C0SQK1, A0A8C0STJ7, A0A8I3PJB0, A0A8I3PPA7
      Conserved Domains (1) summary
      pfam01044
      Location:82 → 867
      Vinculin; Vinculin family
    Nucleotide Protein
    Heading Accession and Version

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