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Ctnna1 catenin alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 12385, updated on 8-Feb-2024

Summary

Official Symbol
Ctnna1provided by MGI
Official Full Name
catenin alpha 1provided by MGI
Primary source
MGI:MGI:88274
See related
Ensembl:ENSMUSG00000037815 AllianceGenome:MGI:88274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Catna1; 2010010M04Rik
Summary
Enables actin filament binding activity and identical protein binding activity. Involved in negative regulation of protein localization to nucleus. Acts upstream of or within several processes, including apical junction assembly; negative regulation of neuroblast proliferation; and regulation of signal transduction. Located in several cellular components, including intercalated disc; lamellipodium; and zonula adherens. Part of flotillin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study patterned macular dystrophy 2. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 52.1), placenta adult (RPKM 48.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ctnna1 in Genome Data Viewer
Location:
18 B1; 18 18.89 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35251955..35387829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35118902..35254776)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36037 Neighboring gene STARR-seq mESC enhancer starr_44222 Neighboring gene predicted gene, 41690 Neighboring gene STARR-seq mESC enhancer starr_44224 Neighboring gene predicted gene 3587 Neighboring gene predicted gene, 46617 Neighboring gene STARR-seq mESC enhancer starr_44229 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene STARR-positive B cell enhancer ABC_E10985 Neighboring gene STARR-seq mESC enhancer starr_44230 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene predicted gene, 57657 Neighboring gene STARR-seq mESC enhancer starr_44231 Neighboring gene predicted gene, 57820

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apical junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to indole-3-methanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in zonula adherens IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
catenin alpha-1
Names
102 kDa cadherin-associated protein
CAP102
alpha E-catenin
cadherin associated protein
catenin (cadherin associated protein), alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009818.1NP_033948.1  catenin alpha-1

    See identical proteins and their annotated locations for NP_033948.1

    Status: PROVISIONAL

    Source sequence(s)
    X59990
    Consensus CDS
    CCDS29139.1
    UniProtKB/Swiss-Prot
    P26231
    UniProtKB/TrEMBL
    Q3TGQ3, Q545R0
    Related
    ENSMUSP00000049007.7, ENSMUST00000042345.8
    Conserved Domains (1) summary
    pfam01044
    Location:82867
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35251955..35387829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250299.1XP_030106159.1  catenin alpha-1 isoform X1

    UniProtKB/Swiss-Prot
    P26231
    UniProtKB/TrEMBL
    Q3TGQ3, Q545R0
    Conserved Domains (1) summary
    pfam01044
    Location:82867
    Vinculin; Vinculin family
  2. XM_036160954.1XP_036016847.1  catenin alpha-1 isoform X2

    Conserved Domains (1) summary
    pfam01044
    Location:1497
    Vinculin; Vinculin family
  3. XM_006525548.4XP_006525611.1  catenin alpha-1 isoform X2

    See identical proteins and their annotated locations for XP_006525611.1

    Conserved Domains (1) summary
    pfam01044
    Location:1497
    Vinculin; Vinculin family