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    ZNF420 zinc finger protein 420 [ Homo sapiens (human) ]

    Gene ID: 147923, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF420provided by HGNC
    Official Full Name
    zinc finger protein 420provided by HGNC
    Primary source
    HGNC:HGNC:20649
    See related
    Ensembl:ENSG00000197050 MIM:617216; AllianceGenome:HGNC:20649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APAK
    Summary
    The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in testis (RPKM 3.6), ovary (RPKM 3.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37007902..37130368)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39682827..39805340)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37569124..37621270)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 568 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14538 Neighboring gene zinc finger protein 585A Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients. Gaykalova DA, et al. PLoS One, 2015. PMID 26544568, Free PMC Article
    2. Differential regulation of Apak by various DNA damage signals. Wang S, et al. Mol Cell Biochem, 2010 Jan. PMID 19629643
    3. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Tian C, et al. Nat Cell Biol, 2009 May. PMID 19377469
    4. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. Olcina MM, et al. Oncogene, 2016 Feb 11. PMID 25961932, Free PMC Article
    5. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. Yuan L, et al. EMBO Rep, 2012 Apr. PMID 22334068, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional importance of H3K9me3 in hypoxia, apoptosis and repression of APAK.
      Title: H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.
    2. ARF coordinates Apak to regulate ribosome biogenesis upon cellular stress.
      Title: ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.
    3. Apak competes with p53 for binding to inhibit p53AIP1 expression.
      Title: Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.
    4. Apak is differentially regulated in the ARF and ATM-dependent manner in response to oncogenic stress and DNA damage, respectively.
      Title: ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
    5. four of seven types of DNA damage signals examined resulted in significant Apak phosphorylation and dissociation of Apak from p53, releasing the inhibition of p53 transcriptional activity
      Title: Differential regulation of Apak by various DNA damage signals.
    6. Apak (ZNF420 or FLJ32191) is a negative regulator of p53-mediated apoptosis.
      Title: KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32191

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 420
    Names
    ATM and p53-associated KZNF protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051212.1 RefSeqGene

      Range
      75619..127554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329515.3 → NP_001316444.1  zinc finger protein 420 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC010632, AC012309

    2. NM_001329516.3 → NP_001316445.1  zinc finger protein 420 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:165 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:561 → 581
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001329517.1 → NP_001316446.1  zinc finger protein 420 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform d, as do variants 5, 6, and 7.
      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001329518.1 → NP_001316447.1  zinc finger protein 420 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform d, as do variants 4, 6, and 7.
      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001329519.1 → NP_001316448.1  zinc finger protein 420 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform d, as do variants 4, 5, and 7.
      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001329520.1 → NP_001316449.1  zinc finger protein 420 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform d, as do variants 4, 5, and 6.
      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001329521.3 → NP_001316450.1  zinc finger protein 420 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC010632, AC012309
      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490 → 510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:503 → 527
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001329522.3 → NP_001316451.1  zinc finger protein 420 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC010632, AC012309, AK056753
      Consensus CDS
      CCDS86757.1
      UniProtKB/Swiss-Prot
      Q8TAQ5
      Related
      ENSP00000306102.7, ENST00000304239.11
      Conserved Domains (6) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:137 → 472
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:223 → 245
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001329524.3 → NP_001316453.1  zinc finger protein 420 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC010632, AC012309

    10. NM_144689.5 → NP_653290.2  zinc finger protein 420 isoform b

      See identical proteins and their annotated locations for NP_653290.2

      Status: REVIEWED

      Source sequence(s)
      AC012309, AK315728
      Consensus CDS
      CCDS12498.1
      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5
      Related
      ENSP00000338770.2, ENST00000337995.4
      Conserved Domains (4) summary
      COG5048
      Location:165 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:589 → 609
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 46
      KRAB; KRAB box
      pfam13465
      Location:629 → 654
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_138039.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC010632

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37007902..37130368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438230.1 → XP_047294186.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    2. XM_011526503.3 → XP_011524805.1  zinc finger protein 420 isoform X1

      See identical proteins and their annotated locations for XP_011524805.1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5
      Conserved Domains (4) summary
      COG5048
      Location:165 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:589 → 609
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 46
      KRAB; KRAB box
      pfam13465
      Location:629 → 654
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011526510.3 → XP_011524812.1  zinc finger protein 420 isoform X3

      See identical proteins and their annotated locations for XP_011524812.1

      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047438229.1 → XP_047294185.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    5. XM_011526507.4 → XP_011524809.1  zinc finger protein 420 isoform X3

      See identical proteins and their annotated locations for XP_011524809.1

      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011526504.3 → XP_011524806.1  zinc finger protein 420 isoform X1

      See identical proteins and their annotated locations for XP_011524806.1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5
      Conserved Domains (4) summary
      COG5048
      Location:165 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:589 → 609
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 46
      KRAB; KRAB box
      pfam13465
      Location:629 → 654
      zf-H2C2_2; Zinc-finger double domain

    7. XM_011526508.3 → XP_011524810.1  zinc finger protein 420 isoform X3

      See identical proteins and their annotated locations for XP_011524810.1

      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    8. XM_006723038.4 → XP_006723101.1  zinc finger protein 420 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:165 → 577
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:561 → 581
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    9. XM_011526511.3 → XP_011524813.1  zinc finger protein 420 isoform X5

      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:137 → 477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393 → 413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    10. XM_047438232.1 → XP_047294188.1  zinc finger protein 420 isoform X5

    11. XM_047438231.1 → XP_047294187.1  zinc finger protein 420 isoform X4

    12. XM_017026338.2 → XP_016881827.1  zinc finger protein 420 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:94 → 506
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:558 → 583
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39682827..39805340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319914.1 → XP_054175889.1  zinc finger protein 420 isoform X3

    2. XM_054319909.1 → XP_054175884.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    3. XM_054319908.1 → XP_054175883.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    4. XM_054319906.1 → XP_054175881.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    5. XM_054319912.1 → XP_054175887.1  zinc finger protein 420 isoform X3

    6. XM_054319907.1 → XP_054175882.1  zinc finger protein 420 isoform X1

      UniProtKB/Swiss-Prot
      B2RDY6, Q8TAQ5, Q96ML5

    7. XM_054319911.1 → XP_054175886.1  zinc finger protein 420 isoform X3

    8. XM_054319910.1 → XP_054175885.1  zinc finger protein 420 isoform X2

    9. XM_054319915.1 → XP_054175890.1  zinc finger protein 420 isoform X5

    10. XM_054319916.1 → XP_054175891.1  zinc finger protein 420 isoform X5

    11. XM_054319913.1 → XP_054175888.1  zinc finger protein 420 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAQ5.1 GenPept UniProtKB/Swiss-Prot:Q8TAQ5

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