RNF8 ring finger protein 8 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: RNF8provided by VGNC
Official Full Name: ring finger protein 8provided by VGNC
Primary source: VGNC:VGNC:76708
See related: Ensembl:ENSMMUG00000011573
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (132036484..132075643, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (38306127..38345970)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH45129 (e-PCR)
- UniSTS:77725

RH93720 (e-PCR)
- UniSTS:90574

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables histone binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info	PubMed
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase RNF8

NP_001252758.1

EC 2.1.1.57

EC 2.3.2.27

XP_014991615.1

EC 2.1.1.57

EC 2.3.2.27

XP_014991616.1

EC 2.1.1.57

EC 2.3.2.27

XP_014991617.1

EC 2.1.1.57

EC 2.3.2.27

XP_028702431.1

EC 2.1.1.57

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001265829.1 → NP_001252758.1 E3 ubiquitin-protein ligase RNF8

See identical proteins and their annotated locations for NP_001252758.1

Status: PROVISIONAL

Source sequence(s)

JU477714

UniProtKB/TrEMBL

F7BPC7, F7BPD6, G7MP74

Related

ENSMMUP00000001722.3, ENSMMUT00000001826.4

Conserved Domains (5) summary

COG1716
Location:21 → 109

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:17 → 110

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00162
Location:403 → 445

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd16269
Location:395 → 405

GBP_C; coiled coil [structural motif]

cl20817
Location:284 → 405

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041757.1 Reference Mmul_10 Primary Assembly

Range

132036484..132075643 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028846598.1 → XP_028702431.1 E3 ubiquitin-protein ligase RNF8 isoform X1

UniProtKB/TrEMBL

G7MP74

Conserved Domains (3) summary

cd00060
Location:17 → 110

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam09787
Location:265 → 389

Golgin_A5; Golgin subfamily A member 5

cl17238
Location:377 → 406

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_015136129.2 → XP_014991615.1 E3 ubiquitin-protein ligase RNF8 isoform X2

UniProtKB/TrEMBL

G7MP74

Conserved Domains (4) summary

COG1716
Location:21 → 109

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:17 → 110

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd16269
Location:395 → 405

GBP_C; coiled coil [structural motif]

cl20817
Location:284 → 405

GBP_C; Guanylate-binding protein, C-terminal domain
XM_015136130.2 → XP_014991616.1 E3 ubiquitin-protein ligase RNF8 isoform X3

UniProtKB/TrEMBL

G7MP74

Conserved Domains (4) summary

COG1716
Location:1 → 52

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:2 → 53

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00162
Location:346 → 388

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam15035
Location:227 → 323

Rootletin; Ciliary rootlet component, centrosome cohesion
XM_015136131.2 → XP_014991617.1 E3 ubiquitin-protein ligase RNF8 isoform X4

UniProtKB/TrEMBL

G7MP74

Conserved Domains (3) summary

COG1716
Location:21 → 109

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:17 → 110

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd00162
Location:348 → 379

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...