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    Scarb1 scavenger receptor class B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20778, updated on 25-Jun-2017
    Official Symbol
    Scarb1provided by MGI
    Official Full Name
    scavenger receptor class B, member 1provided by MGI
    Primary source
    MGI:MGI:893578
    See related
    Ensembl:ENSMUSG00000037936 Vega:OTTMUSG00000022742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD36; Cla1; SRBI; Srb1; Cla-1; Hdlq1; SR-B1; SR-BI; Cd36l1; Chohd1; Hlb398; mSR-BI; AI120173; D5Ertd460e
    Orthologs
    Location:
    5 64.11 cM; 5 G1.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (125277087..125341094, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125757460..125821444, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene nuclear receptor co-repressor 2 Neighboring gene predicted gene, 32585 Neighboring gene predicted gene, 32701 Neighboring gene predicted gene, 40323 Neighboring gene predicted gene, 40324

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Fat digestion and absorption, organism-specific biosystem (from KEGG)
      Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fat digestion and absorption, conserved biosystem (from KEGG)
      Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      HDL-mediated lipid transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Retinol metabolism, organism-specific biosystem (from WikiPathways)
      Retinol metabolism, organism-specific biosystemThis pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities
    • Scavenging by Class B Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class B Receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Statin Pathway, organism-specific biosystem (from WikiPathways)
      Statin Pathway, organism-specific biosystemWhat are statins? See Wikipedia at: http://en.wikipedia.org/wiki/Statin More about this pathway and statins: https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amyloid-beta binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apolipoprotein A-I binding ISO
    Inferred from Sequence Orthology
    more info
     
    apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high-density lipoprotein particle receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
     
    androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    high-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    high-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide transport ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phagocytosis, recognition ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    recognition of apoptotic cell ISO
    Inferred from Sequence Orthology
    more info
     
    recognition of apoptotic cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphatidylcholine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reverse cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vitamin transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    scavenger receptor class B member 1
    Names
    HDL QTL 1
    scavenger receptor class B type I
    scavenger receptor class B1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205082.1NP_001192011.1  scavenger receptor class B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001192011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK010622, AK028191, BQ176029, BY018765
      Consensus CDS
      CCDS57383.1
      UniProtKB/Swiss-Prot
      Q61009
      UniProtKB/TrEMBL
      D3Z2V4
      Related
      ENSMUSP00000107021.1, OTTMUSP00000026064, ENSMUST00000111390.7, OTTMUST00000054566
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family
    2. NM_001205083.1NP_001192012.1  scavenger receptor class B member 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs at the 3' end compared to variant 1. This results in a frame-shift and a longer isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK143368, AK145588, BY018765
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family
    3. NM_016741.2NP_058021.1  scavenger receptor class B member 1 isoform 1

      See identical proteins and their annotated locations for NP_058021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AK028191, BQ176029, BY018765
      Consensus CDS
      CCDS19683.1
      UniProtKB/Swiss-Prot
      Q61009
      UniProtKB/TrEMBL
      Q4FK30
      Related
      ENSMUSP00000083242.6, OTTMUSP00000026063, ENSMUST00000086075.12, OTTMUST00000054565
      Conserved Domains (1) summary
      pfam01130
      Location:26447
      CD36; CD36 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      125277087..125341094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320764.1XP_017176253.1  scavenger receptor class B member 1 isoform X1

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