U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SCARB1 scavenger receptor class B member 1 [ Homo sapiens (human) ]

Gene ID: 949, updated on 1-Oct-2024

Summary

Official Symbol
SCARB1provided by HGNC
Official Full Name
scavenger receptor class B member 1provided by HGNC
Primary source
HGNC:HGNC:1664
See related
Ensembl:ENSG00000073060 MIM:601040; AllianceGenome:HGNC:1664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLCQ6; HDLQTL6
Summary
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SCARB1 in Genome Data Viewer
Location:
12q24.31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124776856..124863864, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124782134..124869001, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125261402..125348410, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125106212-125107104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125107105-125107998 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:125117605-125118804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125120143-125120783 Neighboring gene Sharpr-MPRA regulatory region 4504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125130641-125131250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136287-125136800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136801-125137314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125158286-125158903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125160065-125160662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125161261-125161858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169899-125170441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169354-125169898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125172481-125173202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125179365-125179866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125197387-125198032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125198033-125198677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125215664-125216268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125216269-125216872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125218412-125219186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125219187-125219961 Neighboring gene uncharacterized LOC124903045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125234102-125234622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125234623-125235143 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125239799-125240701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125242645-125243146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125243147-125243646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125245231-125245731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7300 Neighboring gene Sharpr-MPRA regulatory region 2215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7303 Neighboring gene MPRA-validated peak2030 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125268792-125269560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125270855-125271355 Neighboring gene uncharacterized LOC124903046 Neighboring gene MPRA-validated peak2031 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125282050-125282560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125282561-125283071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125301275-125301774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125309151-125309872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125309873-125310594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125323854-125324380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125324381-125324905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125346238-125346764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5067 Neighboring gene uncharacterized LOC105370050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7306 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25236 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:125351043-125352242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125369125-125369812 Neighboring gene CRISPRi-validated cis-regulatory element chr12.4732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7308 Neighboring gene RNA, U6 small nuclear 927, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
High density lipoprotein cholesterol level quantitative trait locus 6
MedGen: C1853096 OMIM: 610762 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
EBI GWAS Catalog
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
EBI GWAS Catalog
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding TAS
Traceable Author Statement
more info
PubMed 
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
enables apolipoprotein A-I binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
enables high-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables high-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipopolysaccharide immune receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adhesion of symbiont to host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cholesterol import IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in high-density lipoprotein particle remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intestinal lipid absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in recognition of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of phagocytosis IC
Inferred by Curator
more info
PubMed 
involved_in regulation of phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reverse cholesterol transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vitamin transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane HDA PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
scavenger receptor class B member 1
Names
CD36 and LIMPII analogous 1
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
scavenger receptor class B type III

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028199.1 RefSeqGene

    Range
    5110..92118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001082959.2NP_001076428.1  scavenger receptor class B member 1 isoform 2

    See identical proteins and their annotated locations for NP_001076428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073593, AC126309
    Consensus CDS
    CCDS45008.1
    UniProtKB/TrEMBL
    A0A7P0T9I2
    Related
    ENSP00000343795.4, ENST00000339570.9
    Conserved Domains (1) summary
    pfam01130
    Location:16446
    CD36; CD36 family
  2. NM_001367981.1NP_001354910.1  scavenger receptor class B member 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC073593, AC126309, BC022087
    Consensus CDS
    CCDS91769.1
    UniProtKB/Swiss-Prot
    F8W8N0, Q14016, Q52LZ5, Q6KFX4, Q8WTV0
    UniProtKB/TrEMBL
    A0A0S2Z3N2
    Related
    ENSP00000414979.2, ENST00000415380.6
  3. NM_001367982.1NP_001354911.1  scavenger receptor class B member 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, AK124112
    UniProtKB/TrEMBL
    B3KW46, B4DZ71
    Related
    ENSP00000444851.1, ENST00000544327.1
  4. NM_001367983.1NP_001354912.1  scavenger receptor class B member 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    UniProtKB/TrEMBL
    A0A7P0T9I2
  5. NM_001367984.1NP_001354913.1  scavenger receptor class B member 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    UniProtKB/TrEMBL
    A0A7P0T9I2
  6. NM_001367985.1NP_001354914.1  scavenger receptor class B member 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    UniProtKB/TrEMBL
    A0A7P0T9I2
  7. NM_001367986.1NP_001354915.1  scavenger receptor class B member 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, BC143319
    Consensus CDS
    CCDS91770.1
    UniProtKB/TrEMBL
    A0A7P0T913, B7ZKQ9
    Related
    ENSP00000442862.1, ENST00000546215.5
  8. NM_001367987.1NP_001354916.1  scavenger receptor class B member 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    Consensus CDS
    CCDS91771.1
    UniProtKB/TrEMBL
    A0A7P0T9I2, A0A7P0Z4E3
    Related
    ENSP00000505757.1, ENST00000680556.1
  9. NM_001367988.1NP_001354917.1  scavenger receptor class B member 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  10. NM_001367989.1NP_001354918.1  scavenger receptor class B member 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC073593, AC126309
    Consensus CDS
    CCDS9259.1
    UniProtKB/TrEMBL
    A0A7P0T9I2
    Conserved Domains (1) summary
    pfam01130
    Location:16446
    CD36; CD36 family
  11. NM_005505.5NP_005496.4  scavenger receptor class B member 1 isoform 1

    See identical proteins and their annotated locations for NP_005496.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 13 both encode the same isoform (1).
    Source sequence(s)
    AC073593, BC080647, BG770204, CA428516
    Consensus CDS
    CCDS9259.1
    UniProtKB/TrEMBL
    A0A7P0T9I2
    Related
    ENSP00000261693.6, ENST00000261693.11
    Conserved Domains (1) summary
    pfam01130
    Location:16446
    CD36; CD36 family

RNA

  1. NR_160416.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  2. NR_160417.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  3. NR_160418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    Related
    ENST00000679605.1
  4. NR_160419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  5. NR_160420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  6. NR_160421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  7. NR_160422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  8. NR_160423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  9. NR_160424.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
    Related
    ENST00000680926.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    124776856..124863864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    124782134..124869001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)