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SCARB1 scavenger receptor class B member 1 [ Homo sapiens (human) ]

Gene ID: 949, updated on 22-Aug-2020

Summary

Official Symbol
SCARB1provided by HGNC
Official Full Name
scavenger receptor class B member 1provided by HGNC
Primary source
HGNC:HGNC:1664
See related
Ensembl:ENSG00000073060 MIM:601040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
Summary
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019]
Expression
Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues See more
Orthologs

Genomic context

See SCARB1 in Genome Data Viewer
Location:
12q24.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (124776856..124863864, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125262174..125348519, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927436 Neighboring gene Sharpr-MPRA regulatory region 4504 Neighboring gene uncharacterized LOC105370050 Neighboring gene uncharacterized LOC107984444 Neighboring gene uncharacterized LOC105370051 Neighboring gene CRISPRi-validated cis-regulatory element chr12.4732

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
GeneReviews: Not available
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
GeneReviews: Not available
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
GeneReviews: Not available
High density lipoprotein cholesterol level quantitative trait locus 6
MedGen: C1853096 OMIM: 610762 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding TAS
Traceable Author Statement
more info
PubMed 
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
apolipoprotein A-I binding IPI
Inferred from Physical Interaction
more info
PubMed 
apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adhesion of symbiont to host IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol import IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phagocytosis IC
Inferred by Curator
more info
PubMed 
regulation of phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
reverse cholesterol transport IEP
Inferred from Expression Pattern
more info
PubMed 
triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
vitamin transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
caveola TAS
Traceable Author Statement
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane HDA PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
scavenger receptor class B member 1
Names
CD36 and LIMPII analogous 1
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
scavenger receptor class B type III

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028199.1 RefSeqGene

    Range
    5110..92118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001082959.2NP_001076428.1  scavenger receptor class B member 1 isoform 2

    See identical proteins and their annotated locations for NP_001076428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073593, AC126309
    Consensus CDS
    CCDS45008.1
    UniProtKB/Swiss-Prot
    Q8WTV0
    Related
    ENSP00000343795.4, ENST00000339570.9
    Conserved Domains (1) summary
    pfam01130
    Location:18446
    CD36; CD36 family
  2. NM_001367981.1NP_001354910.1  scavenger receptor class B member 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC073593, AC126309, BC022087
    Related
    ENSP00000414979.2, ENST00000415380.6
  3. NM_001367982.1NP_001354911.1  scavenger receptor class B member 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, AK124112
    Related
    ENSP00000444851.1, ENST00000544327.1
  4. NM_001367983.1NP_001354912.1  scavenger receptor class B member 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  5. NM_001367984.1NP_001354913.1  scavenger receptor class B member 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  6. NM_001367985.1NP_001354914.1  scavenger receptor class B member 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  7. NM_001367986.1NP_001354915.1  scavenger receptor class B member 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, BC143319
    Related
    ENSP00000442862.1, ENST00000546215.5
  8. NM_001367987.1NP_001354916.1  scavenger receptor class B member 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  9. NM_001367988.1NP_001354917.1  scavenger receptor class B member 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  10. NM_001367989.1NP_001354918.1  scavenger receptor class B member 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC073593, AC126309
  11. NM_005505.5NP_005496.4  scavenger receptor class B member 1 isoform 1

    See identical proteins and their annotated locations for NP_005496.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 13 both encode the same isoform (1).
    Source sequence(s)
    AC073593, BC080647, BG770204, CA428516
    Consensus CDS
    CCDS9259.1
    UniProtKB/Swiss-Prot
    Q8WTV0
    UniProtKB/TrEMBL
    A0A024RBS4
    Related
    ENSP00000261693.6, ENST00000261693.11
    Conserved Domains (1) summary
    pfam01130
    Location:18446
    CD36; CD36 family

RNA

  1. NR_160416.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  2. NR_160417.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  3. NR_160418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  4. NR_160419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  5. NR_160420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  6. NR_160421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  7. NR_160422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  8. NR_160423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  9. NR_160424.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    124776856..124863864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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