CDH2 cadherin 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CDH2provided by VGNC
Official Full Name: cadherin 2provided by VGNC
Primary source: VGNC:VGNC:39028
See related: Ensembl:ENSCAFG00845012116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: NCAD
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (60754899..60968628)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (60142523..60355795)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (60744933..60958801)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (60431048..60644193)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (60442612..60655854)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest the assembly of focal adhesion like puncta requires the cytoplasmic domain of N-cadherin.
Title: Deletion of the cytoplasmic domain of N-cadherin reduces, but does not eliminate, traction force-transmission.

Submit: New GeneRIF Correction

General gene information

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Markers

REN15692 (e-PCR)
- UniSTS:340492

ECD08545 (e-PCR)
- UniSTS:289593

REN16026 (e-PCR)
- UniSTS:340826

REN16027 (e-PCR)
- UniSTS:340827

GDB:193186 (e-PCR)
- UniSTS:155743

D18S1292 (e-PCR)
- UniSTS:53361

CDH2 (e-PCR)
- UniSTS:266629

stSG624309 (e-PCR)
- UniSTS:455860

CDH2 (e-PCR)
- UniSTS:262856

REN15626 (e-PCR)
- UniSTS:340426

stSG624345 (e-PCR)
- UniSTS:455891

REN15383 (e-PCR)
- UniSTS:340183

REN16155 (e-PCR)
- UniSTS:340955

REN16156 (e-PCR)
- UniSTS:340956

REN16157 (e-PCR)
- UniSTS:340957

REN16158 (e-PCR)
- UniSTS:340958

GDB:196601 (e-PCR)
- UniSTS:155872

REN15397 (e-PCR)
- UniSTS:340197

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in intercalated disc	IEA Inferred from Electronic Annotation more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cadherin-2

Names: neural cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287156.2 → NP_001274085.2 cadherin-2 precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000022

UniProtKB/TrEMBL

A0A8C0LR90, A0A8I3NAG2

Related

ENSCAFP00845016947.1, ENSCAFT00845021565.1

Conserved Domains (5) summary

cd11304
Location:273 → 378

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:751 → 904

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:31 → 121

Cadherin_pro; Cadherin prodomain like

cl28889
Location:163 → 263

CA_like; Cadherin repeat-like domain

cl29226
Location:608 → 701

Cadherin; Cadherin domain