U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdh2 cadherin 2 [ Mus musculus (house mouse) ]

Gene ID: 12558, updated on 22-Jan-2023

Summary

Official Symbol
Cdh2provided by MGI
Official Full Name
cadherin 2provided by MGI
Primary source
MGI:MGI:88355
See related
Ensembl:ENSMUSG00000024304 AllianceGenome:MGI:88355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDHN; Ncad; N-CAD
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 20.7), CNS E14 (RPKM 19.4) and 14 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cdh2 in Genome Data Viewer
Location:
18 A1; 18 10.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (16721934..16942303, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (16588877..16809246, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A11 (calgizzarin) pseudogene Neighboring gene predicted gene, 30765 Neighboring gene predicted gene 15328 Neighboring gene ribosomal protein 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood vessel morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within brain morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuroepithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuroligin clustering involved in postsynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within radial glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynaptic density protein 95 clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in desmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in fascia adherens IDA
Inferred from Direct Assay
more info
PubMed 
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in intercalated disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-2
Names
N-cadherin
neural cadherin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007664.5NP_031690.3  cadherin-2 preproprotein

    See identical proteins and their annotated locations for NP_031690.3

    Status: REVIEWED

    Source sequence(s)
    AA242226, AC134570, AK032826, AK146981, CB246984
    Consensus CDS
    CCDS29076.1
    UniProtKB/Swiss-Prot
    P15116, Q6GU11
    UniProtKB/TrEMBL
    A0A8C6GAL5, Q3UIC2, Q8BSI9
    Related
    ENSMUSP00000025166.8, ENSMUST00000025166.14
    Conserved Domains (4) summary
    cd11304
    Location:273378
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:759902
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:31121
    Cadherin_pro; Cadherin prodomain like
    cl09101
    Location:163263
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    16721934..16942303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525553.2XP_006525616.1  cadherin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GA10
    Conserved Domains (6) summary
    cd11304
    Location:236341
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:352452
    Cadherin; Cadherin domain
    cl29226
    Location:573664
    Cadherin; Cadherin domain
    pfam01049
    Location:714867
    Cadherin_C; Cadherin cytoplasmic region
    cl07391
    Location:1984
    Cadherin_pro; Cadherin prodomain like
    cl28889
    Location:126226
    CA_like; Cadherin repeat-like domain