Format

Send to:

Choose Destination
    • Showing Current items.

    RHPN1 rhophilin Rho GTPase binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 114822, updated on 17-Jun-2019

    Summary

    Official Symbol
    RHPN1provided by HGNC
    Official Full Name
    rhophilin Rho GTPase binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:19973
    See related
    Ensembl:ENSG00000158106 MIM:601031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ODF5; RHPN; RHOPHILIN
    Expression
    Broad expression in brain (RPKM 2.9), kidney (RPKM 2.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See RHPN1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143368827..143384221)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144451025..144466390)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase I mitochondrial Neighboring gene RNA, U6 small nuclear 220, pseudogene Neighboring gene RHPN1 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC107986984 Neighboring gene MAFA antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed
    nucleocapsid gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystemRhotekin (RTKN) is a protein with an N-terminally located RHO GTPase binding domain, that shares a limited sequence homology with PKNs and rhophilins. RTKN binds to GTP-bound RHOA, RHOB and RHOC and ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA1929

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rhophilin-1
    Names
    GTP-Rho-binding protein 1
    outer dense fiber of sperm tails 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052924.3NP_443156.2  rhophilin-1

      See identical proteins and their annotated locations for NP_443156.2

      Status: VALIDATED

      Source sequence(s)
      AC105118, BC025767, BX341691
      Consensus CDS
      CCDS47927.1
      UniProtKB/Swiss-Prot
      Q8TCX5
      Related
      ENSP00000289013.6, ENST00000289013.11
      Conserved Domains (3) summary
      cd09248
      Location:109493
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:514580
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:21105
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      143368827..143384221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516823.2XP_011515125.1  rhophilin-1 isoform X10

      Conserved Domains (2) summary
      cl00087
      Location:74158
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14649
      Location:162529
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
    2. XM_017013014.1XP_016868503.1  rhophilin-1 isoform X11

    3. XM_017013013.1XP_016868502.1  rhophilin-1 isoform X6

    4. XM_011516817.2XP_011515119.1  rhophilin-1 isoform X1

      Conserved Domains (3) summary
      cd09248
      Location:162552
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:573639
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:74158
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    5. XM_006716502.3XP_006716565.1  rhophilin-1 isoform X2

      Conserved Domains (3) summary
      cd09248
      Location:162551
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:572638
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:74158
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    6. XM_005250772.3XP_005250829.1  rhophilin-1 isoform X3

      See identical proteins and their annotated locations for XP_005250829.1

      Conserved Domains (3) summary
      cd09248
      Location:162546
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:567633
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:74158
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    7. XM_017013016.1XP_016868505.1  rhophilin-1 isoform X13

    8. XM_005250773.3XP_005250830.1  rhophilin-1 isoform X4

      Conserved Domains (3) summary
      cd09248
      Location:162545
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:566632
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:74158
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    9. XM_011516819.2XP_011515121.1  rhophilin-1 isoform X7

      Conserved Domains (3) summary
      cd09248
      Location:109499
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:520586
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:21105
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    10. XM_011516822.3XP_011515124.1  rhophilin-1 isoform X9

      See identical proteins and their annotated locations for XP_011515124.1

      Conserved Domains (3) summary
      cd09248
      Location:60450
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:471537
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:156
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    11. XM_017013015.1XP_016868504.1  rhophilin-1 isoform X12

    12. XM_011516818.1XP_011515120.1  rhophilin-1 isoform X5

      Conserved Domains (3) summary
      cd09248
      Location:145535
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:556622
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:57141
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    13. XM_011516821.2XP_011515123.1  rhophilin-1 isoform X9

      See identical proteins and their annotated locations for XP_011515123.1

      Conserved Domains (3) summary
      cd09248
      Location:60450
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:471537
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:156
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    14. XM_011516820.2XP_011515122.1  rhophilin-1 isoform X8

      Conserved Domains (3) summary
      cd09248
      Location:97487
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      smart00228
      Location:508574
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cl00087
      Location:993
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RNA

    1. XR_001745465.1 RNA Sequence

      Related
      ENST00000522335.5
    Support Center