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TPI1 triosephosphate isomerase 1 [ Homo sapiens (human) ]

Gene ID: 7167, updated on 17-Jun-2019

Summary

Official Symbol
TPI1provided by HGNC
Official Full Name
triosephosphate isomerase 1provided by HGNC
Primary source
HGNC:HGNC:12009
See related
Ensembl:ENSG00000111669 MIM:190450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM; TPI; TPID; HEL-S-49
Summary
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in heart (RPKM 181.7), brain (RPKM 179.1) and 25 other tissues See more
Orthologs

Genomic context

See TPI1 in Genome Data Viewer
Location:
12p13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6866834..6870946)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6976288..6980110)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene uncharacterized LOC105369632 Neighboring gene ribosomal protein L13 pseudogene 5 Neighboring gene DSTN pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of triosephosphate isomerase 1 (TPI1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88108

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methylglyoxal synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
triose-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triose-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
triose-phosphate isomerase activity NAS
Non-traceable Author Statement
more info
PubMed 
triose-phosphate isomerase activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glyceraldehyde-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glyceraldehyde-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylglyoxal biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
triosephosphate isomerase
Names
epididymis secretory protein Li 49
methylglyoxal synthase
triose-phosphate isomerase
NP_000356.1
NP_001152759.1
NP_001244955.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011948.1 RefSeqGene

    Range
    5001..8527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000365.5NP_000356.1  triosephosphate isomerase isoform 1

    See identical proteins and their annotated locations for NP_000356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AK222638, BC009329, DB444195
    Consensus CDS
    CCDS8566.1
    UniProtKB/Swiss-Prot
    P60174
    UniProtKB/TrEMBL
    Q53HE2, V9HWK1
    Related
    ENSP00000379933.4, ENST00000396705.10
    Conserved Domains (1) summary
    PTZ00333
    Location:2247
    PTZ00333; triosephosphate isomerase; Provisional
  2. NM_001159287.1NP_001152759.1  triosephosphate isomerase isoform 2

    See identical proteins and their annotated locations for NP_001152759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The resulting isoform has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    DB444195, M10036, U47924
    Consensus CDS
    CCDS53740.1
    UniProtKB/Swiss-Prot
    P60174
    Related
    ENSP00000484435.1, ENST00000613953.4
    Conserved Domains (1) summary
    PTZ00333
    Location:39284
    PTZ00333; triosephosphate isomerase; Provisional
  3. NM_001258026.1NP_001244955.1  triosephosphate isomerase isoform 3

    See identical proteins and their annotated locations for NP_001244955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298809, AW250466
    Consensus CDS
    CCDS58206.1
    UniProtKB/Swiss-Prot
    P60174
    Related
    ENSP00000443599.1, ENST00000535434.5
    Conserved Domains (1) summary
    cl21457
    Location:1165
    ICL_KPHMT; Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6866834..6870946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957378.1 RNA Sequence

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