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Tpi1 triosephosphate isomerase 1 [ Mus musculus (house mouse) ]

Gene ID: 21991, updated on 8-Jan-2023

Summary

Official Symbol
Tpi1provided by MGI
Official Full Name
triosephosphate isomerase 1provided by MGI
Primary source
MGI:MGI:98797
See related
Ensembl:ENSMUSG00000023456 AllianceGenome:MGI:98797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIM; Tpi; Tpi-1
Summary
Enables triose-phosphate isomerase activity. Involved in glyceraldehyde-3-phosphate metabolic process. Acts upstream of or within glucose metabolic process. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 378.7), kidney adult (RPKM 378.5) and 28 other tissues See more
Orthologs
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Genomic context

See Tpi1 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124787549..124791121, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124810586..124814158, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 23 Neighboring gene predicted gene, 38895 Neighboring gene predicted gene, 38894 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene ubiquitin specific peptidase 5 (isopeptidase T) Neighboring gene cell division cycle associated 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables methylglyoxal synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables triose-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables triose-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triose-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables triose-phosphate isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
triosephosphate isomerase
Names
methylglyoxal synthase
triose-phosphate isomerase
NP_033441.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009415.3NP_033441.3  triosephosphate isomerase

    Status: VALIDATED

    Source sequence(s)
    AK008034, AK010808, BC046761, BU945752, CD766215
    Consensus CDS
    CCDS20530.2
    UniProtKB/Swiss-Prot
    Q9CWE7
    Related
    ENSMUSP00000130858.4, ENSMUST00000172132.10
    Conserved Domains (1) summary
    PTZ00333
    Location:2247
    PTZ00333; triosephosphate isomerase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124787549..124791121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)