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SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens (human) ]

Gene ID: 6446, updated on 19-Sep-2024

Summary

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Official Symbol
SGK1provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase 1provided by HGNC
Primary source
HGNC:HGNC:10810
See related
Ensembl:ENSG00000118515 MIM:602958; AllianceGenome:HGNC:10810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGK
Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Expression
Broad expression in small intestine (RPKM 111.9), gall bladder (RPKM 85.9) and 24 other tissues See more
Orthologs
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Genomic context

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See SGK1 in Genome Data Viewer
Location:
6q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (134169256..134318112, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (135357191..135506235, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134490394..134639250, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901404 Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr6:134481640-134482141 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134496091-134496592 Neighboring gene Sharpr-MPRA regulatory region 71 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S29 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25086 Neighboring gene RNA, 5S ribosomal pseudogene 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134617783-134618284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134632359-134632918 Neighboring gene keratin 8 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25089 Neighboring gene uncharacterized LOC105378009 Neighboring gene SGK1-CHCHD2P4 intergenic CAGE-defined mid-level expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17559 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [SGK1 as a therapeutic target for central nervous system diseases]. Xing YK, et al. Sheng Li Xue Bao, 2023 Jun 25. PMID 37340653
  2. Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients. Zhang J, et al. Breast Cancer Res Treat, 2023 Aug. PMID 37286891
  3. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. Giannetti F, et al. Europace, 2023 May 19. PMID 37099628, Free PMC Article
  4. SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells. Hara Y, et al. Blood Adv, 2023 Jun 13. PMID 36696461, Free PMC Article
  5. Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation. Bapat A, et al. JCI Insight, 2022 Oct 10. PMID 35998035, Free PMC Article

See all (295) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury.
    Title: MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury.
  2. Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1.
    Title: Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1.
  3. Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
    Title: Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
  4. Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression.
    Title: Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression.
  5. SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
    Title: SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
  6. Proteomics on malignant pleural effusions reveals ERalpha loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.
    Title: Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.
  7. Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.
    Title: Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.
  8. Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
    Title: Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
  9. Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
    Title: Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
  10. Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.
    Title: Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.
Submit: New GeneRIF Correction See all GeneRIFs (231)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serum/glucocorticoid regulated kinase SGK1 is important for HIV-1 replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables chloride channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium channel regulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to aldosterone IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term memory TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transporter activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of catalytic activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of gastric acid secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
  
involved_in renal sodium ion absorption TAS
Traceable Author Statement
more info
 PubMed 
involved_in sodium ion transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk1
Names
serine/threonine protein kinase SGK
NP_001137148.1
NP_001137149.1
NP_001137150.1
NP_001278924.1
NP_005618.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143676.3 → NP_001137148.1  serine/threonine-protein kinase Sgk1 isoform 2

    See identical proteins and their annotated locations for NP_001137148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.
    Source sequence(s)
    AL135839, AL355881, Z84486
    Consensus CDS
    CCDS47476.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000356832.5, ENST00000367858.10
    Conserved Domains (2) summary
    smart00220
    Location:193 → 450
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05575
    Location:197 → 519
    STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

  2. NM_001143677.2 → NP_001137149.1  serine/threonine-protein kinase Sgk1 isoform 3

    See identical proteins and their annotated locations for NP_001137149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (3) with a longer and an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AK098509, BP384292, DA309338
    Consensus CDS
    CCDS47477.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000434450.1, ENST00000528577.5
    Conserved Domains (1) summary
    cd05575
    Location:130 → 452
    STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

  3. NM_001143678.2 → NP_001137150.1  serine/threonine-protein kinase Sgk1 isoform 4

    See identical proteins and their annotated locations for NP_001137150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (4) with a longer and an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AK098509, BP384292, DC428953
    Consensus CDS
    CCDS47478.1
    UniProtKB/TrEMBL
    B7Z325
    Related
    ENSP00000396242.3, ENST00000413996.7
    Conserved Domains (1) summary
    cd05602
    Location:104 → 442
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

  4. NM_001291995.2 → NP_001278924.1  serine/threonine-protein kinase Sgk1 isoform 5

    See identical proteins and their annotated locations for NP_001278924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF153609, AK295422, DB450096
    Consensus CDS
    CCDS78184.1
    UniProtKB/TrEMBL
    B7Z325, E9PR89
    Related
    ENSP00000434302.1, ENST00000475719.6
    Conserved Domains (1) summary
    cl21453
    Location:90 → 384
    PKc_like; Protein Kinases, catalytic domain

  5. NM_005627.4 → NP_005618.2  serine/threonine-protein kinase Sgk1 isoform 1

    See identical proteins and their annotated locations for NP_005618.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AK098509, BP384292, DB450096
    Consensus CDS
    CCDS5170.1
    UniProtKB/Swiss-Prot
    B7UUP7, B7UUP8, B7UUP9, B7Z5B2, E1P583, O00141, Q5TCN2, Q5TCN3, Q5TCN4, Q5VY65, Q9UN56
    UniProtKB/TrEMBL
    B7Z325
    Related
    ENSP00000237305.7, ENST00000237305.12
    Conserved Domains (1) summary
    cd05602
    Location:90 → 428
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    134169256..134318112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    135357191..135506235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00141.2 GenPept UniProtKB/Swiss-Prot:O00141

Gene LinkOut

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