FAAH fatty acid amide hydrolase [Homo sapiens (human)] - Gene

Summary

Official Symbol: FAAHprovided by HGNC
Official Full Name: fatty acid amide hydrolaseprovided by HGNC
Primary source: HGNC:HGNC:3553
See related: Ensembl:ENSG00000117480 MIM:602935; AllianceGenome:HGNC:3553
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSAB; FAAH1; FAAH-1
Summary: This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Expression: Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (46394317..46413845)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (46271530..46291059)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (46859989..46879517)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
Title: Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.
Title: FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.
Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.
Title: Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.
Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [[11]C]CURB in Heavy-Drinking Youth.
Title: Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [(11)C]CURB in Heavy-Drinking Youth.
Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.
Title: Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.
Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.
Title: Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.
The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.
Title: The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.
Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.
Title: Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.
Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.
Title: Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.
Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.
Title: Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.

Submit: New GeneRIF Correction See all GeneRIFs (146)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Polysubstance abuse, susceptibility to MedGen: C1847831 OMIM: 606581 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26106-26107:1032553127:3 (e-PCR)
- UniSTS:268941

FAAH (e-PCR)
- UniSTS:503224

SHGC-74781 (e-PCR)
- UniSTS:76031

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid amide hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid amide hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid amide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acid amide hydrolase activity	TAS Traceable Author Statement more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	TAS Traceable Author Statement more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty-acid amide hydrolase 1

Names: anandamide amidohydrolase 1; fatty acid ester hydrolase; oleamide hydrolase 1

NP_001432.2

EC 3.5.1.99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.