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FAAH fatty acid amide hydrolase [ Homo sapiens (human) ]

Gene ID: 2166, updated on 15-Apr-2019

Summary

Official Symbol
FAAHprovided by HGNC
Official Full Name
fatty acid amide hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:3553
See related
Ensembl:ENSG00000117480 MIM:602935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSAB; FAAH-1
Summary
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
Orthologs

Genomic context

See FAAH in Genome Data Viewer
Location:
1p33
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (46394267..46413848)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46859939..46879520)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene fatty acid amide hydrolase pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1398

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • anandamide degradation, organism-specific biosystem (from BIOCYC)
    anandamide degradation, organism-specific biosystemAnandamide, a member of the endocannabinoid class of signaling lipids, is the amide of ethanolamine and arachidonate. It is part of the endocannabinoid system, a neural signaling pathway consisting...
  • anandamide degradation, conserved biosystem (from BIOCYC)
    anandamide degradation, conserved biosystemAnandamide, a member of the endocannabinoid class of signaling lipids, is the amide of ethanolamine and arachidonate. It is part of the endocannabinoid system, a neural signaling pathway consisting...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102823, MGC138146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 
amidase activity IEA
Inferred from Electronic Annotation
more info
 
anandamide amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid amide hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid amide hydrolase activity TAS
Traceable Author Statement
more info
 
oleamide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
fatty-acid amide hydrolase 1
Names
anandamide amidohydrolase 1
oleamide hydrolase 1
NP_001432.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012195.1 RefSeqGene

    Range
    5001..24582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001441.3NP_001432.2  fatty-acid amide hydrolase 1

    See identical proteins and their annotated locations for NP_001432.2

    Status: REVIEWED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS535.1
    UniProtKB/Swiss-Prot
    O00519
    UniProtKB/TrEMBL
    Q9UG55
    Related
    ENSP00000243167.8, ENST00000243167.9
    Conserved Domains (1) summary
    pfam01425
    Location:95562
    Amidase; Amidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    46394267..46413848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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