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Faah fatty acid amide hydrolase [ Mus musculus (house mouse) ]

Gene ID: 14073, updated on 18-Apr-2024

Summary

Official Symbol
Faahprovided by MGI
Official Full Name
fatty acid amide hydrolaseprovided by MGI
Primary source
MGI:MGI:109609
See related
Ensembl:ENSMUSG00000034171 AllianceGenome:MGI:109609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables acylglycerol lipase activity. Predicted to be involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in organelle membrane. Is expressed in several structures, including alimentary system; brain; ganglia; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 30.1), duodenum adult (RPKM 29.3) and 22 other tissues See more
Orthologs
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Genomic context

Location:
4 D1; 4 53.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115853866..115876034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115996668..116018837, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene diencephalon/mesencephalon homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_11128 Neighboring gene predicted gene, 38492 Neighboring gene STARR-seq mESC enhancer starr_11131 Neighboring gene NOL1/NOP2/Sun domain family, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amidase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid amide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid amide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fatty-acid amide hydrolase 1
Names
amide hydrolase
anandamide amidohydrolase 1
fatty acid amide hydrolase protein
fatty acid ester hydrolase
oleamide hydrolase 1
NP_034303.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010173.6NP_034303.3  fatty-acid amide hydrolase 1

    See identical proteins and their annotated locations for NP_034303.3

    Status: VALIDATED

    Source sequence(s)
    AL627105
    Consensus CDS
    CCDS18501.1
    UniProtKB/Swiss-Prot
    O08914, Q922S0, Q9DBF5
    UniProtKB/TrEMBL
    Q8C541
    Related
    ENSMUSP00000041543.5, ENSMUST00000049095.6
    Conserved Domains (1) summary
    pfam01425
    Location:95562
    Amidase; Amidase

RNA

  1. NR_151700.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627105
  2. NR_185205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627105

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115853866..115876034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001784090.2 RNA Sequence

  2. XR_001784089.2 RNA Sequence