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FAAH fatty acid amide hydrolase [ Homo sapiens (human) ]

Gene ID: 2166, updated on 1-Aug-2020

Summary

Official Symbol
FAAHprovided by HGNC
Official Full Name
fatty acid amide hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:3553
See related
Ensembl:ENSG00000117480 MIM:602935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSAB; FAAH-1
Summary
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
Orthologs

Genomic context

See FAAH in Genome Data Viewer
Location:
1p33
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (46394317..46413845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46859939..46879520)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene fatty acid amide hydrolase pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1398

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102823, MGC138146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anandamide amidohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid amide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid amide hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid amide hydrolase activity TAS
Traceable Author Statement
more info
 
oleamide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
monoacylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
fatty-acid amide hydrolase 1
Names
anandamide amidohydrolase 1
fatty acid ester hydrolase
oleamide hydrolase 1
NP_001432.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012195.1 RefSeqGene

    Range
    5001..24582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001441.3NP_001432.2  fatty-acid amide hydrolase 1

    See identical proteins and their annotated locations for NP_001432.2

    Status: REVIEWED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS535.1
    UniProtKB/Swiss-Prot
    O00519
    UniProtKB/TrEMBL
    Q9UG55
    Related
    ENSP00000243167.8, ENST00000243167.9
    Conserved Domains (1) summary
    pfam01425
    Location:95562
    Amidase; Amidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    46394317..46413845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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