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NSUN4 NOP2/Sun RNA methyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 387338, updated on 23-Nov-2021

Summary

Official Symbol
NSUN4provided by HGNC
Official Full Name
NOP2/Sun RNA methyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:31802
See related
Ensembl:ENSG00000117481 MIM:615394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHTAP
Expression
Broad expression in testis (RPKM 13.3), thyroid (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

See NSUN4 in Genome Data Viewer
Location:
1p33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (46340807..46385199)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46806479..46850871)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAD54 like Neighboring gene leucine rich repeat containing 41 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene fatty acid amide hydrolase Neighboring gene fatty acid amide hydrolase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FAAH

Homology

Clone Names

  • FLJ18051, MGC22960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA (cytosine-C5-)-methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA methylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
5-methylcytosine rRNA methyltransferase NSUN4
Names
5-methylcytosine tRNA methyltransferase NSUN4
NOL1/NOP2/Sun domain family member 4
NOP2/Sun RNA methyltransferase family member 4
NOP2/Sun domain family, member 4
putative methyltransferase NSUN4
sperm head and tail associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256127.3NP_001243056.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform b

    See identical proteins and their annotated locations for NP_001243056.1

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS57996.1
    UniProtKB/Swiss-Prot
    Q96CB9
    Related
    ENSP00000437758.1, ENST00000537428.2
    Conserved Domains (1) summary
    COG0144
    Location:106333
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  2. NM_001256128.3NP_001243057.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform b

    See identical proteins and their annotated locations for NP_001243057.1

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS57996.1
    UniProtKB/Swiss-Prot
    Q96CB9
    UniProtKB/TrEMBL
    A8K8I8
    Conserved Domains (1) summary
    COG0144
    Location:106333
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  3. NM_001387265.1NP_001374194.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155381
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  4. NM_001387266.1NP_001374195.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155326
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  5. NM_001387267.1NP_001374196.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:3358
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  6. NM_001387268.1NP_001374197.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155326
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  7. NM_001387269.1NP_001374198.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155326
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  8. NM_001387270.1NP_001374199.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155259
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  9. NM_001387271.1NP_001374200.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155252
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  10. NM_001387272.1NP_001374201.1  5-methylcytosine rRNA methyltransferase NSUN4 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Conserved Domains (1) summary
    COG0144
    Location:155259
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  11. NM_199044.4NP_950245.2  5-methylcytosine rRNA methyltransferase NSUN4 isoform a

    See identical proteins and their annotated locations for NP_950245.2

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS534.1
    UniProtKB/Swiss-Prot
    Q96CB9
    Related
    ENSP00000419740.1, ENST00000474844.6
    Conserved Domains (1) summary
    COG0144
    Location:155382
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_045789.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  2. NR_045790.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
    Related
    ENST00000307089.7
  3. NR_045791.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  4. NR_170617.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  5. NR_170618.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  6. NR_170619.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  7. NR_170620.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  8. NR_170621.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  9. NR_170622.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  10. NR_170623.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001
  11. NR_170624.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL122001

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    46340807..46385199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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