tiparp TCDD-inducible poly(ADP-ribose) polymerase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tiparpprovided by ZNC
Official Full Name: TCDD-inducible poly(ADP-ribose) polymeraseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031002-47
See related: Ensembl:ENSDARG00000061841 AllianceGenome:ZFIN:ZDB-GENE-031002-47
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc03g05; sb:cb841; wu:fc03g05; zgc:153056; si:dkey-33k14.4
Summary: Predicted to enable NAD+ ADP-ribosyltransferase activity and zinc ion binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Is expressed in several structures, including digestive system; forebrain neural keel; nervous system; neural plate; and neural tube. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (34599315..34642086)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (34623291..34666062)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb97d12.x1 (e-PCR)
- UniSTS:187673

fc03g05.x1 (e-PCR)
- UniSTS:203687

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase TIPARP

NP_001038484.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045019.3 → NP_001038484.1 protein mono-ADP-ribosyltransferase TIPARP

Status: VALIDATED

Source sequence(s)

AI601719, CA472479, EB882039, EB973772, EE311950, EE316647, EH433035, EH459039

UniProtKB/TrEMBL

A0A0R4IVH6, A0A8M1N9V5

Related

ENSDARP00000138590.1, ENSDART00000159306.2

Conserved Domains (3) summary

cd01439
Location:518 → 637

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam00644
Location:455 → 637

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam02825
Location:327 → 390

WWE; WWE domain