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TIPARP TCDD inducible poly(ADP-ribose) polymerase [ Homo sapiens (human) ]

Gene ID: 25976, updated on 29-Mar-2023

Summary

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Official Symbol
TIPARPprovided by HGNC
Official Full Name
TCDD inducible poly(ADP-ribose) polymeraseprovided by HGNC
Primary source
HGNC:HGNC:23696
See related
Ensembl:ENSG00000163659 MIM:612480; AllianceGenome:HGNC:23696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARP7; ARTD14; pART14
Summary
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in adrenal (RPKM 28.8), esophagus (RPKM 23.5) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See TIPARP in Genome Data Viewer
Location:
3q25.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (156674590..156706770)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (159449273..159481452)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156392379..156424559)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:156251527-156252026 Neighboring gene signal sequence receptor subunit 3 Neighboring gene TIPARP antisense RNA 1 Neighboring gene methyltransferase like 15 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:156468641-156469394 Neighboring gene long intergenic non-protein coding RNA 886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TIPARP is involved in the regulation of intraocular pressure. Zhang Y, et al. Commun Biol, 2022 Dec 19. PMID 36536086, Free PMC Article
  2. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Gozgit JM, et al. Cancer Cell, 2021 Sep 13. PMID 34375612
  3. Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. Palavalli Parsons LH, et al. Elife, 2021 Jan 21. PMID 33475085, Free PMC Article
  4. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. de Waard PW, et al. Chem Biol Interact, 2008 Oct 22. PMID 18762178
  5. PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells. Rasmussen M, et al. Cells, 2021 Mar 11. PMID 33799807, Free PMC Article

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIPARP is involved in the regulation of intraocular pressure.
    Title: TIPARP is involved in the regulation of intraocular pressure.
  2. Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells.
    Title: Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells.
  3. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
    Title: Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
  4. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
    Title: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
  5. PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.
    Title: PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus.
  6. PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor alpha Signaling in Human Breast Cancer Cells.
    Title: PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells.
  7. Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
    Title: Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling.
  8. Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
    Title: Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly.
  9. TiPARP forms nuclear condensates to degrade HIF-1alpha and suppress tumorigenesis.
    Title: TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis.
  10. circHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy.
    Title: Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
EBI GWAS Catalog
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40466, DKFZp434J214, DKFZp686N0351, DKFZp686P1838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+- protein-cysteine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in female gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase TIPARP
Names
ADP-ribosyltransferase diphtheria toxin-like 14
poly [ADP-ribose] polymerase 7
NP_001171646.1
NP_001171647.1
NP_056323.2
XP_047303891.1
XP_047303892.1
XP_047303893.1
XP_054202092.1
XP_054202093.1
XP_054202094.1
XP_054202095.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184717.1 → NP_001171646.1  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_001171646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1, Q9Y4P7
    Related
    ENSP00000420612.1, ENST00000461166.5
    Conserved Domains (3) summary
    cd01439
    Location:529 → 648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466 → 648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346 → 401
    WWE; WWE domain

  2. NM_001184718.2 → NP_001171647.1  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_001171647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC034397, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1, Q9Y4P7
    UniProtKB/TrEMBL
    Q05BQ2
    Related
    ENSP00000438345.1, ENST00000542783.5
    Conserved Domains (3) summary
    cd01439
    Location:529 → 648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466 → 648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346 → 401
    WWE; WWE domain

  3. NM_015508.5 → NP_056323.2  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_056323.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1, Q9Y4P7
    Related
    ENSP00000295924.7, ENST00000295924.12
    Conserved Domains (3) summary
    cd01439
    Location:529 → 648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466 → 648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346 → 401
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    156674590..156706770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447936.1 → XP_047303892.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

  2. XM_047447937.1 → XP_047303893.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

  3. XM_047447935.1 → XP_047303891.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4P7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    159449273..159481452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346118.1 → XP_054202093.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

  2. XM_054346117.1 → XP_054202092.1  protein mono-ADP-ribosyltransferase TIPARP isoform X1

  3. XM_054346119.1 → XP_054202094.1  protein mono-ADP-ribosyltransferase TIPARP isoform X2

  4. XM_054346120.1 → XP_054202095.1  protein mono-ADP-ribosyltransferase TIPARP isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z3E1.1 GenPept UniProtKB/Swiss-Prot:Q7Z3E1

Gene LinkOut

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Chemical Information
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