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TIPARP TCDD inducible poly(ADP-ribose) polymerase [ Homo sapiens (human) ]

Gene ID: 25976, updated on 1-Jun-2020

Summary

Official Symbol
TIPARPprovided by HGNC
Official Full Name
TCDD inducible poly(ADP-ribose) polymeraseprovided by HGNC
Primary source
HGNC:HGNC:23696
See related
Ensembl:ENSG00000163659 MIM:612480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARP7; ARTD14; pART14
Summary
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in adrenal (RPKM 28.8), esophagus (RPKM 23.5) and 24 other tissues See more
Orthologs

Genomic context

See TIPARP in Genome Data Viewer
Location:
3q25.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (156674590..156706770)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156392205..156424559)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member regulatory beta subunit 1 Neighboring gene KCNAB1 antisense RNA 1 Neighboring gene signal sequence receptor subunit 3 Neighboring gene uncharacterized LOC107986148 Neighboring gene TIPARP antisense RNA 1 Neighboring gene methyltransferase like 15 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 886 Neighboring gene proliferation-associated 2G4 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
NHGRI GWA Catalog
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
NHGRI GWA Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40466, DKFZp434J214, DKFZp686N0351, DKFZp686P1838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
female gonad development IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
response to 2,3,7,8-tetrachlorodibenzodioxine IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase TIPARP
Names
ADP-ribosyltransferase diphtheria toxin-like 14
poly [ADP-ribose] polymerase 7
NP_001171646.1
NP_001171647.1
NP_056323.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184717.1NP_001171646.1  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_001171646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1
    Related
    ENSP00000420612.1, ENST00000461166.5
    Conserved Domains (3) summary
    cd01439
    Location:529648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346401
    WWE; WWE domain
  2. NM_001184718.1NP_001171647.1  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_001171647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC034397, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1
    UniProtKB/TrEMBL
    Q05BQ2
    Related
    ENSP00000438345.1, ENST00000542783.5
    Conserved Domains (3) summary
    cd01439
    Location:529648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346401
    WWE; WWE domain
  3. NM_015508.5NP_056323.2  protein mono-ADP-ribosyltransferase TIPARP

    See identical proteins and their annotated locations for NP_056323.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC092927, BC050350, BX537965
    Consensus CDS
    CCDS3177.1
    UniProtKB/Swiss-Prot
    Q7Z3E1
    Related
    ENSP00000295924.7, ENST00000295924.12
    Conserved Domains (3) summary
    cd01439
    Location:529648
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:466648
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl02729
    Location:346401
    WWE; WWE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    156674590..156706770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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