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    RAB11FIP3 RAB11 family interacting protein 3 [ Homo sapiens (human) ]

    Gene ID: 9727, updated on 11-Apr-2024

    Summary

    Official Symbol
    RAB11FIP3provided by HGNC
    Official Full Name
    RAB11 family interacting protein 3provided by HGNC
    Primary source
    HGNC:HGNC:17224
    See related
    Ensembl:ENSG00000090565 MIM:608738; AllianceGenome:HGNC:17224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIP3; CART1; FIP3-Rab11; Rab11-FIP3
    Summary
    Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in kidney (RPKM 33.4), brain (RPKM 8.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    16p13.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (425649..523011)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (421839..526088)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (475649..573011)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:492123-492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495322-495822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495823-496323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516240-516869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516870-517498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:532003-532508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:534533-535038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:535039-535544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:537093-537971 Neighboring gene uncharacterized LOC107987417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:542303-542924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544383-544961 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544962-545539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:576271-576832 Neighboring gene long intergenic non-protein coding RNA 235 Neighboring gene calpain 15 Neighboring gene microRNA 5587

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0665, PAC196A12.1, MU-MB-17.148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein light intermediate chain binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dynein light intermediate chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to recycling endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of adiponectin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cytokinetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of early endosome to recycling endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rab11 family-interacting protein 3
    Names
    EF hands-containing Rab-interacting protein
    MU-MB-17.148
    RAB11 family interacting protein 3 (class II)
    arfophilin-1
    cytoplasmic adaptor for RAR and TR
    eferin
    NP_001135744.2
    NP_001357330.1
    NP_055515.1
    XP_005255771.1
    XP_005255772.1
    XP_005255774.1
    XP_005255775.1
    XP_011521066.1
    XP_011521067.1
    XP_016879396.1
    XP_047290915.1
    XP_047290916.1
    XP_054170469.1
    XP_054170470.1
    XP_054170471.1
    XP_054170472.1
    XP_054170473.1
    XP_054170474.1
    XP_054185167.1
    XP_054185168.1
    XP_054185169.1
    XP_054185170.1
    XP_054185171.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142272.2NP_001135744.2  rab11 family-interacting protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL049542, Z98882
      Related
      ENSP00000415919.1, ENST00000450428.5
      Conserved Domains (2) summary
      TIGR02168
      Location:160432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09457
      Location:406446
      RBD-FIP; FIP domain
    2. NM_001370401.1NP_001357330.1  rab11 family-interacting protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL023881, AL049542, Z98882
      Consensus CDS
      CCDS92071.1
      UniProtKB/TrEMBL
      A0A0J9YWV4, X6RFI8
      Related
      ENSP00000399644.2, ENST00000434585.6
      Conserved Domains (4) summary
      PRK07764
      Location:3223
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      TIGR02168
      Location:515787
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09457
      Location:761801
      RBD-FIP; FIP domain
      pfam13499
      Location:206264
      EF-hand_7; EF-hand domain pair
    3. NM_014700.4NP_055515.1  rab11 family-interacting protein 3 isoform 1

      See identical proteins and their annotated locations for NP_055515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL023881, BC051360, Z98882
      Consensus CDS
      CCDS32351.1
      UniProtKB/Swiss-Prot
      B0QYI8, B0QYT8, B1AHQ0, B4DEI7, B4DZR6, O75154, Q4VXV7, Q7Z5E9, Q9H155, Q9H1G0, Q9NUI0
      UniProtKB/TrEMBL
      A0A0J9YWV4, X6RFI8
      Related
      ENSP00000262305.4, ENST00000262305.9
      Conserved Domains (8) summary
      COG1842
      Location:459674
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      pfam09457
      Location:716756
      RBD-FIP; FIP domain
      pfam05700
      Location:486589
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam11262
      Location:540631
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam13499
      Location:207263
      EF-hand_7; EF-hand domain pair
      pfam15068
      Location:80140
      FAM101; FAM101 family
      pfam16034
      Location:577691
      JAKMIP_CC3; JAKMIP CC3 domain
      cl08302
      Location:206264
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      425649..523011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023907.2XP_016879396.1  rab11 family-interacting protein 3 isoform X1

    2. XM_005255717.4XP_005255774.1  rab11 family-interacting protein 3 isoform X4

      See identical proteins and their annotated locations for XP_005255774.1

      Conserved Domains (3) summary
      cd00051
      Location:206264
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:207263
      EF-hand_7; EF-hand domain pair
      pfam16214
      Location:85220
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    3. XM_005255718.4XP_005255775.1  rab11 family-interacting protein 3 isoform X6

      See identical proteins and their annotated locations for XP_005255775.1

      Conserved Domains (3) summary
      cd00051
      Location:206264
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:207263
      EF-hand_7; EF-hand domain pair
      pfam16214
      Location:85220
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    4. XM_047434960.1XP_047290916.1  rab11 family-interacting protein 3 isoform X7

    5. XM_011522765.3XP_011521067.1  rab11 family-interacting protein 3 isoform X5

      See identical proteins and their annotated locations for XP_011521067.1

      Conserved Domains (4) summary
      COG1842
      Location:162377
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      pfam09457
      Location:419459
      RBD-FIP; FIP domain
      pfam05700
      Location:189292
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam11262
      Location:243334
      Tho2; Transcription factor/nuclear export subunit protein 2
    6. XM_011522764.3XP_011521066.1  rab11 family-interacting protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011521066.1

      UniProtKB/Swiss-Prot
      O75154
      Conserved Domains (2) summary
      TIGR02168
      Location:205477
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09457
      Location:451491
      RBD-FIP; FIP domain
    7. XM_005255715.6XP_005255772.1  rab11 family-interacting protein 3 isoform X3

      See identical proteins and their annotated locations for XP_005255772.1

      UniProtKB/Swiss-Prot
      O75154
      Conserved Domains (2) summary
      TIGR02168
      Location:205477
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09457
      Location:451491
      RBD-FIP; FIP domain
    8. XM_047434959.1XP_047290915.1  rab11 family-interacting protein 3 isoform X3

    9. XM_005255714.2XP_005255771.1  rab11 family-interacting protein 3 isoform X2

      See identical proteins and their annotated locations for XP_005255771.1

      Conserved Domains (5) summary
      COG1842
      Location:208423
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      pfam09457
      Location:465505
      RBD-FIP; FIP domain
      pfam05700
      Location:235338
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam11262
      Location:289380
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam16034
      Location:326440
      JAKMIP_CC3; JAKMIP CC3 domain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187610.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      24795..125679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329195.1XP_054185170.1  rab11 family-interacting protein 3 isoform X4

    2. XM_054329196.1XP_054185171.1  rab11 family-interacting protein 3 isoform X6

    3. XM_054329193.1XP_054185168.1  rab11 family-interacting protein 3 isoform X3

    4. XM_054329194.1XP_054185169.1  rab11 family-interacting protein 3 isoform X3

    5. XM_054329192.1XP_054185167.1  rab11 family-interacting protein 3 isoform X2

    RNA

    1. XR_008485623.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      421839..526088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314494.1XP_054170469.1  rab11 family-interacting protein 3 isoform X1

    2. XM_054314498.1XP_054170473.1  rab11 family-interacting protein 3 isoform X4

    3. XM_054314499.1XP_054170474.1  rab11 family-interacting protein 3 isoform X6

    4. XM_054314496.1XP_054170471.1  rab11 family-interacting protein 3 isoform X3

    5. XM_054314497.1XP_054170472.1  rab11 family-interacting protein 3 isoform X3

    6. XM_054314495.1XP_054170470.1  rab11 family-interacting protein 3 isoform X2

    RNA

    1. XR_008484754.1 RNA Sequence