U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    IGFN1 immunoglobulin like and fibronectin type III domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 91156, updated on 5-Mar-2024

    Summary

    Official Symbol
    IGFN1provided by HGNC
    Official Full Name
    immunoglobulin like and fibronectin type III domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:24607
    See related
    Ensembl:ENSG00000163395 MIM:617309; AllianceGenome:HGNC:24607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EEF1A2BP1
    Summary
    Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and synapse assembly. Predicted to be located in Z disc and nucleus. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in endometrium (RPKM 9.4), testis (RPKM 3.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1q32.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201190824..201228952)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200447715..200486213)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201159952..201198080)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201084381-201084901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201095506-201096496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201096497-201097487 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:201103675-201103881 Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1687 Neighboring gene transmembrane protein 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201194684-201195676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201252475-201253004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201271917-201272422 Neighboring gene plakophilin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201290713-201291214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201315623-201316123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201316234-201317218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201322652-201323191 Neighboring gene uncharacterized LOC101929326

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434B1231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    immunoglobulin-like and fibronectin type III domain-containing protein 1
    Names
    EEF1A2-binding protein 1
    KY-interacting protein 1
    eEF1A2 binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164586.2NP_001158058.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001158058.1

      Status: VALIDATED

      Source sequence(s)
      AC103925
      Consensus CDS
      CCDS53455.1
      UniProtKB/Swiss-Prot
      Q86VF2
      Related
      ENSP00000334714.4, ENST00000335211.9
      Conserved Domains (5) summary
      cd00096
      Location:36333700
      Ig; Immunoglobulin domain
      smart00410
      Location:34153494
      IG_like; Immunoglobulin like
      cd00063
      Location:33023388
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:29120
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:30173104
      Ig; Immunoglobulin domain
    2. NM_001367841.1NP_001354770.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC103925
      Consensus CDS
      CCDS91141.1
      UniProtKB/Swiss-Prot
      F8WAI1, Q86VF2, Q9NT72
      Related
      ENSP00000295591.9, ENST00000295591.12

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      201190824..201228952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245580.4XP_005245637.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd00096
      Location:36083675
      Ig; Immunoglobulin domain
      smart00410
      Location:33903469
      IG_like; Immunoglobulin like
      cd00063
      Location:32773363
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:29120
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:30173104
      Ig; Immunoglobulin domain
    2. XM_017002787.2XP_016858276.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X2

    3. XM_006711618.4XP_006711681.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X3

      Conserved Domains (4) summary
      cd00096
      Location:29302998
      Ig; Immunoglobulin domain
      cd00063
      Location:33023388
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:29120
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:30173104
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      200447715..200486213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339540.1XP_054195515.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

    2. XM_054339543.1XP_054195518.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    3. XM_054339544.1XP_054195519.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X2

    4. XM_054339545.1XP_054195520.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X3

    5. XM_054339541.1XP_054195516.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

    6. XM_054339542.1XP_054195517.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178275.4: Suppressed sequence

      Description
      NM_178275.4: This RefSeq was permanently suppressed because the CDS was partial.