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    EIF3H eukaryotic translation initiation factor 3 subunit H [ Homo sapiens (human) ]

    Gene ID: 8667, updated on 5-May-2024

    Summary

    Official Symbol
    EIF3Hprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Hprovided by HGNC
    Primary source
    HGNC:HGNC:3273
    See related
    Ensembl:ENSG00000147677 MIM:603912; AllianceGenome:HGNC:3273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3S3; eIF3-p40; eIF3-gamma
    Summary
    Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See EIF3H in Genome Data Viewer
    Location:
    8q23.3-q24.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116642130..116766374, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117769451..117883944, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117654369..117768062, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117543437-117543943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:117595153-117596003 Neighboring gene uncharacterized LOC105375712 Neighboring gene Sharpr-MPRA regulatory region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27827 Neighboring gene uncharacterized LOC105375713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:117690347-117691260 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117702562-117703067 Neighboring gene NANOG hESC enhancer GRCh37_chr8:117742295-117742846 Neighboring gene uncharacterized LOC124902006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27831 Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component Neighboring gene RAD21 cohesin complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
    EBI GWAS Catalog
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    EBI GWAS Catalog
    Genetic variants near PDGFRA are associated with corneal curvature in Australians.
    EBI GWAS Catalog
    Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
    EBI GWAS Catalog
    Meta-analysis of new genome-wide association studies of colorectal cancer risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of eukaryotic translation initiation factor 3, subunit H (EIF3H) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102958

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit H
    Names
    eIF-3-gamma
    eIF3 p40 subunit
    eukaryotic translation initiation factor 3 subunit 3
    eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
    eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
    eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003756.3NP_003747.1  eukaryotic translation initiation factor 3 subunit H

      See identical proteins and their annotated locations for NP_003747.1

      Status: VALIDATED

      Source sequence(s)
      AA902770, AC023520, AU117206, U54559
      Consensus CDS
      CCDS6319.1
      UniProtKB/Swiss-Prot
      O15372
      UniProtKB/TrEMBL
      Q53HG0, Q53HR0, Q6IB98
      Related
      ENSP00000429931.1, ENST00000521861.6
      Conserved Domains (1) summary
      cd08065
      Location:37300
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      116642130..116766374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422386.1XP_047278342.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    2. XM_047422384.1XP_047278340.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    3. XM_047422385.1XP_047278341.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    4. XM_047422383.1XP_047278339.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    5. XM_047422380.1XP_047278336.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    6. XM_047422382.1XP_047278338.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    7. XM_047422381.1XP_047278337.1  eukaryotic translation initiation factor 3 subunit H isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      117769451..117883944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)