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Eif3h eukaryotic translation initiation factor 3, subunit H [ Mus musculus (house mouse) ]

Gene ID: 68135, updated on 6-Jun-2024

Summary

Official Symbol
Eif3hprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Hprovided by MGI
Primary source
MGI:MGI:1915385
See related
Ensembl:ENSMUSG00000022312 AllianceGenome:MGI:1915385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
40kD; Eif3s3; EIF3-P40; EIF3-gamma; 1110008A16Rik; 9430017H16Rik
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in axial skeleton; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 124.1), CNS E14 (RPKM 118.9) and 28 other tissues See more
Orthologs
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Genomic context

See Eif3h in Genome Data Viewer
Location:
15 C; 15 19.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (51649956..51728901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (51786563..51865461, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38649 Neighboring gene predicted gene, 34503 Neighboring gene STARR-seq mESC enhancer starr_38651 Neighboring gene predicted gene, 41320 Neighboring gene STARR-seq mESC enhancer starr_38653 Neighboring gene STARR-positive B cell enhancer ABC_E4132 Neighboring gene STARR-positive B cell enhancer ABC_E5475 Neighboring gene predicted gene, 34678 Neighboring gene UTP23 small subunit processome component Neighboring gene predicted gene, 48923

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit H
Names
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eukaryotic translation initiation factor 3, subunit 3 (gamma)
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418513.1NP_001405442.1  eukaryotic translation initiation factor 3 subunit H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102229
    UniProtKB/TrEMBL
    Q3THW7, Q3TII2, Q8BTX5
  2. NM_001418514.1NP_001405443.1  eukaryotic translation initiation factor 3 subunit H isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102229
    UniProtKB/TrEMBL
    Q3THW7, Q3TII2, Q8BTX5
  3. NM_001418515.1NP_001405444.1  eukaryotic translation initiation factor 3 subunit H isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102229
    UniProtKB/TrEMBL
    Q3THW7, Q3TII2, Q8BTX5
  4. NM_001418516.1NP_001405445.1  eukaryotic translation initiation factor 3 subunit H isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102229
    UniProtKB/TrEMBL
    Q3THW7, Q8BTX5
  5. NM_080635.2NP_542366.1  eukaryotic translation initiation factor 3 subunit H isoform 1

    See identical proteins and their annotated locations for NP_542366.1

    Status: VALIDATED

    Source sequence(s)
    AC102229
    Consensus CDS
    CCDS27461.1
    UniProtKB/Swiss-Prot
    Q91WK2
    UniProtKB/TrEMBL
    Q3THW7, Q3TII2, Q5M9L0, Q8BTX5
    Related
    ENSMUSP00000022925.9, ENSMUST00000022925.10
    Conserved Domains (1) summary
    cd08065
    Location:37300
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    51649956..51728901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)