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EIF3H eukaryotic translation initiation factor 3 subunit H [ Homo sapiens (human) ]

Gene ID: 8667, updated on 22-Aug-2020

Summary

Official Symbol
EIF3Hprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Hprovided by HGNC
Primary source
HGNC:HGNC:3273
See related
Ensembl:ENSG00000147677 MIM:603912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S3; eIF3-p40; eIF3-gamma
Expression
Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more
Orthologs

Genomic context

See EIF3H in Genome Data Viewer
Location:
8q23.3-q24.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (116642130..116755823, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117657055..117768258, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375711 Neighboring gene uncharacterized LOC105375712 Neighboring gene uncharacterized LOC105375713 Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
GeneReviews: Not available
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
GeneReviews: Not available
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
GeneReviews: Not available
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
GeneReviews: Not available
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 3, subunit H (EIF3H) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102958

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
isopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
polysomal ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit H
Names
eIF-3-gamma
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003756.3NP_003747.1  eukaryotic translation initiation factor 3 subunit H

    See identical proteins and their annotated locations for NP_003747.1

    Status: VALIDATED

    Source sequence(s)
    AA902770, AC023520, AU117206, U54559
    Consensus CDS
    CCDS6319.1
    UniProtKB/Swiss-Prot
    O15372
    UniProtKB/TrEMBL
    Q6IB98
    Related
    ENSP00000429931.1, ENST00000521861.6
    Conserved Domains (1) summary
    cd08065
    Location:37300
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    116642130..116755823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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