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EIF3H eukaryotic translation initiation factor 3 subunit H [ Homo sapiens (human) ]

Gene ID: 8667, updated on 6-Sep-2022

Summary

Official Symbol
EIF3Hprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Hprovided by HGNC
Primary source
HGNC:HGNC:3273
See related
Ensembl:ENSG00000147677 MIM:603912; AllianceGenome:HGNC:3273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3S3; eIF3-p40; eIF3-gamma
Summary
Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3H in Genome Data Viewer
Location:
8q23.3-q24.11
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (116642130..116766374, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (117769451..117883944, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117654369..117768062, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375712 Neighboring gene Sharpr-MPRA regulatory region 10947 Neighboring gene uncharacterized LOC105375713 Neighboring gene uncharacterized LOC124902006 Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component Neighboring gene RAD21 cohesin complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
EBI GWAS Catalog
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
EBI GWAS Catalog
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
EBI GWAS Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
EBI GWAS Catalog
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 3, subunit H (EIF3H) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies translation regulatory and RNA binding proteins eIF3h, eEF1A-1, and hnRNPA2 as IN-binding partners PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit H (EIF3H) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102958

Gene Ontology Provided by GOA

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit H
Names
eIF-3-gamma
eIF3 p40 subunit
eukaryotic translation initiation factor 3 subunit 3
eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)
eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD)
eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003756.3NP_003747.1  eukaryotic translation initiation factor 3 subunit H

    See identical proteins and their annotated locations for NP_003747.1

    Status: VALIDATED

    Source sequence(s)
    AA902770, AC023520, AU117206, U54559
    Consensus CDS
    CCDS6319.1
    UniProtKB/Swiss-Prot
    O15372
    UniProtKB/TrEMBL
    Q6IB98
    Related
    ENSP00000429931.1, ENST00000521861.6
    Conserved Domains (1) summary
    cd08065
    Location:37300
    MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    116642130..116766374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422386.1XP_047278342.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  2. XM_047422384.1XP_047278340.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  3. XM_047422385.1XP_047278341.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  4. XM_047422383.1XP_047278339.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  5. XM_047422380.1XP_047278336.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  6. XM_047422382.1XP_047278338.1  eukaryotic translation initiation factor 3 subunit H isoform X1

  7. XM_047422381.1XP_047278337.1  eukaryotic translation initiation factor 3 subunit H isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    117769451..117883944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)