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    Arpc2 actin related protein 2/3 complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 76709, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arpc2provided by MGI
    Official Full Name
    actin related protein 2/3 complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1923959
    See related
    Ensembl:ENSMUSG00000006304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    34kDa; p34-Arc; 2210023N03Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 131.5), bladder adult (RPKM 118.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arpc2 in Genome Data Viewer
    Location:
    1 38.49 cM; 1 C3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (74236505..74268213)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74283124..74314787)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 1928 Neighboring gene predicted gene, 31691 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene predicted gene 28364 Neighboring gene angio-associated migratory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141099

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to rapamycin ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of invadopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Arp2/3 protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament branch point ISO
    Inferred from Sequence Orthology
    more info
     
    apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    invadopodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    peripheral region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    podosome core ISO
    Inferred from Sequence Orthology
    more info
     
    podosome ring ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    ventral surface of cell ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 2
    Names
    arp2/3 complex 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357387.1NP_001344316.1  actin-related protein 2/3 complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      AK152356, BF462332, BY247669
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. NM_029711.2NP_083987.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_083987.1

      Status: VALIDATED

      Source sequence(s)
      AK151513, BF462332, BY247669, BY440113
      Consensus CDS
      CCDS35612.1
      UniProtKB/Swiss-Prot
      Q9CVB6
      Related
      ENSMUSP00000006467.7, ENSMUST00000006467.13
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      74236505..74268213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496317.2XP_006496380.1  actin-related protein 2/3 complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9CVB6
      Related
      ENSMUSP00000109451.2, ENSMUST00000113820.8
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
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