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    Arpc2 actin related protein 2/3 complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 76709, updated on 5-Sep-2021

    Summary

    Official Symbol
    Arpc2provided by MGI
    Official Full Name
    actin related protein 2/3 complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1923959
    See related
    Ensembl:ENSMUSG00000006304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p34-; 34kDa; p34-Arc; 2210023N03Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 131.5), bladder adult (RPKM 118.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arpc2 in Genome Data Viewer
    Location:
    1 38.49 cM; 1 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74275656..74307368)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74236490..74268209)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74283124..74314787)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microRNA 1928 Neighboring gene predicted gene, 31691 Neighboring gene predicted gene, 25524 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene predicted gene 28364 Neighboring gene angio-associated migratory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141099

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to rapamycin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Arp2/3 protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin filament branch point ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in concave side of sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in muscle cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peripheral region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in podosome core ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome ring ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ventral surface of cell ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 2
    Names
    arp2/3 complex 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357387.1NP_001344316.1  actin-related protein 2/3 complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      AK152356, BF462332, BY247669
      Consensus CDS
      CCDS35612.1
      Related
      ENSMUSP00000109451.3, ENSMUST00000113820.9
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. NM_029711.2NP_083987.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_083987.1

      Status: VALIDATED

      Source sequence(s)
      AK151513, BF462332, BY247669, BY440113
      Consensus CDS
      CCDS35612.1
      UniProtKB/Swiss-Prot
      Q9CVB6
      Related
      ENSMUSP00000006467.8, ENSMUST00000006467.14
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74275656..74307368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243491.2XP_030099351.1  actin-related protein 2/3 complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
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