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ARPC2 actin related protein 2/3 complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 10109, updated on 24-Nov-2020

Summary

Official Symbol
ARPC2provided by HGNC
Official Full Name
actin related protein 2/3 complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:705
See related
Ensembl:ENSG00000163466 MIM:604224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC34; PRO2446; p34-Arc; PNAS-139
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues See more
Orthologs

Genomic context

See ARPC2 in Genome Data Viewer
Location:
2q35
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218217138..218254348)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219081817..219119071)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 9 Neighboring gene uncharacterized LOC101928487 Neighboring gene tRNA-Tyr (anticodon ATA) 1-1 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene angio associated migratory cell protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env M-tropic HIV-1 gp120 enhances the binding of WASp and the actin-related protein 2/3 complex with beta-actin, an interaction essential for the proper formation of podosomes in immature monocyte-derived dendritic cells PubMed
env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced association of LSP1, Wiskott-Aldrich Syndrome protein (WASp), Actin-Related Protein 2/3 (Arp2/3), and beta-actin in immature monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
actin polymerization-dependent cell motility TAS
Traceable Author Statement
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Arp2/3 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
muscle cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 2
Names
ARP2/3 protein complex subunit 34
actin related protein 2/3 complex, subunit 2, 34kDa
arp2/3 complex 34 kDa subunit
testis tissue sperm-binding protein Li 53e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005731.3NP_005722.1  actin-related protein 2/3 complex subunit 2

    See identical proteins and their annotated locations for NP_005722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF006085, CN291458
    Consensus CDS
    CCDS2410.1
    UniProtKB/Swiss-Prot
    O15144
    UniProtKB/TrEMBL
    Q53R19
    Related
    ENSP00000295685.10, ENST00000295685.14
    Conserved Domains (1) summary
    pfam04045
    Location:57284
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
  2. NM_152862.3NP_690601.1  actin-related protein 2/3 complex subunit 2

    See identical proteins and their annotated locations for NP_690601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK290268, BG282181, CN291458
    Consensus CDS
    CCDS2410.1
    UniProtKB/Swiss-Prot
    O15144
    UniProtKB/TrEMBL
    Q53R19
    Related
    ENSP00000327137.5, ENST00000315717.10
    Conserved Domains (1) summary
    pfam04045
    Location:57284
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218217138..218254348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003113.1XP_016858602.1  actin-related protein 2/3 complex subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam04045
    Location:2229
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
  2. XM_017003114.1XP_016858603.1  actin-related protein 2/3 complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A024R408
    Conserved Domains (1) summary
    pfam04045
    Location:1170
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
  3. XM_017003115.2XP_016858604.1  actin-related protein 2/3 complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A024R408
    Conserved Domains (1) summary
    pfam04045
    Location:1170
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
  4. XM_024452509.1XP_024308277.1  actin-related protein 2/3 complex subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam04045
    Location:1170
    P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
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