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    Ipo5 importin 5 [ Mus musculus (house mouse) ]

    Gene ID: 70572, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ipo5provided by MGI
    Official Full Name
    importin 5provided by MGI
    Primary source
    MGI:MGI:1917822
    See related
    Ensembl:ENSMUSG00000030662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ra; IMB; Kpn; IMB3; imp5; Kpnb3; C76941; Ranbp5; AA409333; 1110011C18Rik; 5730478E03Rik
    Expression
    Broad expression in testis adult (RPKM 96.4), CNS E11.5 (RPKM 33.8) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ipo5 in Genome Data Viewer
    Location:
    14; 14 E4- E5
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121134255..121185458)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (120896840..120948046)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (121310416..121347268)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33173 Neighboring gene predicted gene, 52124 Neighboring gene FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene serine/threonine kinase 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    importin-5
    Names
    RAN binding protein 5
    importin beta 3
    importin subunit beta-3
    karyopherin (importin) beta 3
    karyopherin beta-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360602.1NP_001347531.1  importin-5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC052392, BC054814, CN708290
      Related
      ENSMUST00000228277.2
      Conserved Domains (3) summary
      COG5215
      Location:14574
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:295327
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:860906
      HEAT_EZ; HEAT-like repeat
    2. NM_023579.4NP_076068.1  importin-5 isoform 1

      See identical proteins and their annotated locations for NP_076068.1

      Status: VALIDATED

      Source sequence(s)
      BC052392, BY767517, CN708290
      Consensus CDS
      CCDS37014.1
      UniProtKB/Swiss-Prot
      Q8BKC5
      Related
      ENSMUSP00000032898.8, ENSMUST00000032898.9
      Conserved Domains (6) summary
      COG5215
      Location:13634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10051051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765874
      Importin_rep_6; Importin repeat 6

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      121134255..121185458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248018.2XP_030103878.1  importin-5 isoform X1

      Conserved Domains (6) summary
      COG5215
      Location:13634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10051051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765874
      Importin_rep_6; Importin repeat 6
    2. XM_030248019.2XP_030103879.1  importin-5 isoform X1

      Conserved Domains (6) summary
      COG5215
      Location:13634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10051051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765874
      Importin_rep_6; Importin repeat 6
    3. XM_036158847.1XP_036014740.1  importin-5 isoform X1

      Conserved Domains (6) summary
      COG5215
      Location:13634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:355387
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:921966
      HEAT_EZ; HEAT-like repeat
      pfam18808
      Location:268357
      Importin_rep_4; Importin repeat
      pfam18816
      Location:10051051
      Importin_rep_5; Importin repeat
      pfam18829
      Location:765874
      Importin_rep_6; Importin repeat 6
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